About-cancer/treatment/clinical-trials/disease/skin-cancer/treatment
Kho Tej Kuaj Mob Rau Cov Neeg Tsis Muaj Kab Mob Khees Xaws Ntawm tawv nqaij
Cov chaw kuaj mob yog cov kev tshawb fawb tshawb fawb uas cuam tshuam nrog tib neeg. Kev kuaj mob hauv cov npe no yog rau kev kho mob tawv nqaij tsis mob melanoma. Txhua qhov kev sim ntawm daim npe tau txhawb los ntawm NCI.
NCI cov ncauj lus tseem ceeb txog kev sim kho mob piav qhia txog ntau hom thiab ncua sij hawm ntawm kev sim thiab seb lawv raug coj los ua li cas. Cov chaw soj ntsuam kuaj xyuas txoj hauv kev tshiab los tiv thaiv, kuaj pom, lossis kho kab mob. Tej zaum koj yuav xav xav txog kev koom tes hauv kev sim tshuaj kuaj mob. Tham nrog koj tus kws kho mob kom pab txiav txim siab yog tias ib qho zoo rau koj.
Kev Sim 1-25 ntawm 118 1 2 3 4 5 Tom ntej>
Lub Hom Phiaj Kho Tau Coj Los ntawm Kev Tshuaj Ntsuam Hauv Kev Kho Mob rau Cov Neeg Mob Nrog Lub Pob Qij Qib Pob Qij Qib, Tawv Qog, lossis Ntau Myeloma (Kev Ntsuam Xyuas MATCH)
Theem II MATCH cov kev sim no yuav kho tau zoo npaum li cas uas yog qhia los ntawm kev tshuaj ntsuam caj ces ua haujlwm rau cov neeg mob qog lossis cov qog ntshav tau nce raws li tsawg kawg ib kab ntawm kev kho mob lossis uas tsis muaj kev pom zoo raws li txoj kev kho tau. Kev tshuaj ntsuam caj ces saib cov cim caj ces (cov caj ces) ntawm cov neeg mob lub qog ua hlav. Cov neeg mob uas muaj caj ces txawv txav (xws li kev sib hloov, ntxiv suab, lossis txav chaw) yuav tau txais txiaj ntsig ntau dua los ntawm kev kho mob uas lub hom phiaj lawv lub qog tshwj xeeb hauv kev mob caj ces. Txheeb xyuas cov kev mob caj ceg no ua ntej yuav pab cov kws kho mob npaj kho zoo dua rau cov neeg mob qog ua hlav, cov qog ntshav, lossis ntau yam mob myeloma.
Qhov chaw: 1189 qhov chaw
Nivolumab tom qab Tshaj Tawm Txheej Txheem Kho Mob hauv Kev Kho Tus Neeg Mob Muaj Mob Nyuaj Mob Ntev II-IIIB Qog Ntshav
Ntu ntawm theem II soj ntsuam kev sim tshuaj no zoo npaum li cas nivolumab tom qab sib xyaw ua ke txoj kev kho ua haujlwm hauv kev kho cov neeg mob uas muaj kev pheej hmoo theem II-IIIB kev mob qog nqaij hlav. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau.
Qhov chaw: 745 qhov chaw
Pembrolizumab piv rau Txuj Ci Kev Saib Xyuas hauv Kev Kho Mob rau Cov Neeg Mob Nrog Tus Mob Zoo Thib I-III Merkel Cell Cancer
Kev sim qib III no tshawb xyuas seb pembrolizumab ua haujlwm zoo npaum li cas piv rau kev saib xyuas kev saib xyuas hauv kev kho mob rau cov neeg mob theem I-III Merkel cell uas raug tshem tawm los ntawm kev phais mob (rov ua haujlwm dua). Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li pembrolizumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau.
Qhov chaw: 286 qhov chaw
Avelumab nrog lossis tsis siv Cetuximab hauv Kev Kho Tus Neeg Mob nrog Kab Mob Qog Nqaij Hlawv Mob Hlwb Cell
Kev sim qib II no kawm paub tias avelumab muaj lossis tsis muaj cetuximab ua haujlwm hauv kev kho cov neeg mob qog nqaij hlav tawv nqaij txhaws tau kis mus rau lwm qhov chaw hauv lub cev (ua ntej). Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li avelumab thiab cetuximab, tuaj yeem pab lub cev tiv thaiv kab mob tua lub qog, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau.
Qhov chaw: 277 thaj chaw
Pembrolizumab nrog lossis tsis Stereotactic Lub Hlav Hluav Taws Xob Kho Mob hauv Kev Kho Mob rau Cov Neeg Mob Muaj Qib Tshaj Plaws lossis Metastatic Merkel Cell
Qhov kev sim kho nyob rau qib II no sim saib pembrolizumab tau zoo npaum li cas nrog lossis tsis muaj kev kho lub cev ntawm lub cev ua haujlwm rau kev kho cov neeg mob Merkel cell cancer uas tau kis mus rau lwm qhov chaw hauv lub cev. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li pembrolizumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Stereotactic lub cev hluav taws xob kho siv cov cuab yeej tshwj xeeb los muab tus neeg mob thiab xa cov hluav taws xob rau cov qog hlav nrog qhov ntsuas siab. Txoj kev no tuaj yeem tua cov qog nqaij hlav nrog cov koob tshuaj tsawg dua nyob rau lub sijhawm luv luv thiab ua rau cov ntaub so ntswg tsawg dua. Kev muab pembrolizumab nrog txoj kev kho mob lub cev stereotactic hluav taws xob tuaj yeem ua haujlwm zoo dua hauv kev kho mob rau cov neeg mob Merkel cell.
Qhov chaw: 246 thaj chaw
Kev Ua Kom Zoo thiab Kev Nyab Xeeb ntawm Tisotumab Vedotin rau Cov Neeg Mob Nrog Lub Pob Qog
Qhov kev sim no yuav kawm txog tisotumab vedotin kom paub seb puas yog ib txoj kev kho mob rau qee cov qog thiab cov kev mob tshwm sim (qhov tsis xav tau) yuav tshwm sim li cas. Txoj kev kho mob yuav muab rau cov neeg mob txhua peb lub lis piam.
Qhov chaw: 12 thaj chaw
PD-1 hauv Cov Neeg Mob Nrog Advanced Basal Cell Carcinoma Leej Twg Muaj Kev Vam Meej ntawm Kab Mob ntawm Hedgehog Pathway Inhibitor Therapy, lossis Tau raug mob siab rau ua ntej Hedgehog Pathway Inhibitor Therapy
Lub hom phiaj tseem ceeb yog kwv yees qhov kev sib tham tag nrho (ORR) rau metastatic Basal Cell Carcinoma (BCC) (pab pawg 1) thiab rau qhov tsis muaj kev tiv thaiv nyob hauv zos BCC (pab pawg 2) thaum kho nrog REGN2810 raws li kev kho mob hlwb
Qhov chaw: 15 thaj chaw
Theem II Kev Tshawb Fawb ntawm Tipifarnib hauv Kev Tsis Tuaj Lub Taub Hau thiab Caj Npab Nrog HRAS Kev Sib Hloov
Kev kawm Ntu II los tshuaj xyuas qhov ua rau antitumor hais txog cov lus teb rau cov hom phiaj (ORR) ntawm cov tshuaj tipifarnib hauv cov ncauj lus ua cov qog ntshav siab uas muaj HRAS hloov mus rau thiab leej twg tsis muaj cov tshuaj kho mob. Daim Ntawv Cim; Tsuas yog koom tes 2 (Head & Caj dab SCC) thiab pawg 3 (Lwm SCC) tam sim no qhib
Qhov chaw: 11 thaj chaw
Qhov Kev Tshawb Nrhiav Kev Tshuaj Tiv Thaiv Tshawb Nrhiav Kev Tshawb Fawb kom paub txog kev nyab xeeb thiab ua tau zoo ntawm Nivolumab, thiab Nivolumab Txoj Kev Kho Mob Nkag mus rau hauv kev mob qog
Lub hom phiaj ntawm txoj kev kawm no los tshawb txog kev nyab xeeb thiab kev ua tau zoo ntawm nivolumab, thiab kev kho nivolumab ua ke, los kho cov neeg mob uas muaj cov qog ua hlav. Qee cov kab mob tau paub ua lub luag haujlwm hauv kev tsim cov qog thiab kev loj hlob. Qhov kev tshawb nrhiav no yuav tshawb txog qhov tshwm sim ntawm cov tshuaj kawm, hauv cov neeg mob uas muaj cov qog loj hauv qab no: - Khees-xaws quav tawm lub qhov quav-Tsis tso npe rau hom mob qog nqaij hlav no - Cervical cancer - Epstein Barr Virus (EBV) zoo mob qog noj ntshav-tsis tuaj yeem sau npe no hom qog nqaij hlav - Merkel Cell Cancer - mob qog nqaij hlav cancer-Tsis teev npe rau hom qog nqaij hlav no - Vaginal thiab vulvar cancer-Tsis tso npe rau hom mob qog no - Nasopharyngeal Cancer - Tsis tso npe rau hom qog nqaij hlav ntxiv - Mob Tawv Hau thiab Caj Dab - Tsis tso npe rau hom mob no ntxiv lawm
Qhov chaw: 10 thaj chaw
Pembrolizumab Versus Placebo Tom Qab Kev Kho Mob thiab Kev Soj Ntsuam hauv Cov Neeg Koom Tes Nrog Lub Hauv Paus hauv Kev Txiav Txim Hlawv Hlawv Mob Hlawv Mob Hlawv Mob Hlawv Mob Hlawv (MK-3475-630 / KEYNOTE-630)
Qhov no yog ib qho kev xaiv, ob qhov muag tsis pom, kev kawm uas sib piv pembrolizumab nrog cov placebo muab raws li kev kho mob nyob rau hauv cov neeg koom nrog cov kev pheej hmoo hauv cheeb tsam tshaj tawm txoj kev txiav cov leeg mob hlwb carcinoma (LA cSCC) uas tau txais kev phais mob nrog curative txhob txwm ua ke nrog radiotherapy. Thawj qhov kev xav yog tias pembrolizumab yog qhov zoo dua rau cov tso tso hauv kev ua kom muaj kev tsis tshua muaj kev ywj pheej (RFS).
Qhov chaw: 10 thaj chaw
Txoj Kev Tshawb Fawb Qhov no Tshuaj Ntsuam Xyuas KRT-232, Qhov Tshiab Tshiab Qhov Ntshav Me Nyuam Mos Cov Hluav Taws Xob ntawm MDM2, rau Kev Kho Mob Rau Cov Neeg Mob Nrog (p53WT) Merkel Cell Carcinoma Leej Twg Ua Tsis Tau Zoo los tiv thaiv PD-1 / PD-L1 Immunotherapy
Txoj kev tshawb no soj ntsuam KRT-232, ib qho tshiab ntawm qhov ncauj me me molecule inhibitor ntawm MDM2, rau kev kho mob ntawm cov neeg mob Merkel Cell Carcinoma (MCC) uas tsis ua tiav kev kho mob nrog tsawg kawg ib qho tshuaj tiv thaiv PD-1 lossis tiv thaiv PD-L1. Kev Txwv tsis pub MDM2 yog qhov kev tawm tswv yim tshiab ntawm kev nqis tes hauv MCC. Txoj kev tshawb no yog ntu 2, Qhib-Label, Ib Sab Caj npab ntawm KRT-232 hauv cov neeg mob nrog p53 Tsiaj qus hom (p53WT) Merkel Cell Carcinoma
Qhov chaw: 11 thaj chaw
Kev Tshawb Fawb Txog XmAb®23104 hauv Cov Kev Kawm Nrog Xaiv Qib Cov Pob Qij Txhuam Qib Dua (DUET-3)
Qhov no yog Ntu 1, ntau koob tshuaj, nce ntxiv koob tshuaj tiv thaiv kev kawm txhawm rau txhawm rau txhais tau tias MTD / RD thiab kev tswj hwm ntawm XmAb23104, kom piav qhia txog kev nyab xeeb thiab tiv taus, soj ntsuam PK thiab immunogenicity, thiab kom soj ntsuam cov tshuaj tiv thaiv qog ua haujlwm ntawm XmAb23104 hauv cov haujlwm nrog xaiv paub ntau yam khoom hlav.
Qhov chaw: 9 thaj chaw
Adjuvant Avelumab hauv Merkel Cell Cancer
Qhov kev sim rau qib III no sim tshawb xyuas seb cov avelumab ua haujlwm zoo li cas rau kev kho cov neeg mob Merkel cell mob cancer uas tau kis mus rau cov qog ntshav thiab tau phais mob nrog lossis tsis muaj kev kho mob hluav taws xob. Cov tshuaj tiv thaiv monoclonal, xws li avelumab, tuaj yeem txhawb lub zog tiv thaiv kab mob thiab cuam tshuam nrog kev muaj peev xwm ntawm cov qog ntshav hlav kom loj hlob thiab kis tau.
Qhov chaw: 10 thaj chaw
QUILT-3.055: Kev Tshawb Fawb txog ALT-803 hauv Kev Tshawb Xyuas Nrog PD-1 / PD-L1 Cov Chaw Soj Ntsuam hauv cov neeg mob uas muaj Kab Mob Qib Siab
Qhov no yog Ntu IIb, ib sab tes, ntau, ib qho qhib daim ntawv lo qhia ntau txoj kev kawm ntawm ALT-803 nrog kev pom zoo ntawm FDA-pom zoo PD-1 / PD-L1 cov tshuaj ntsuam xyuas hauv cov neeg mob uas muaj mob qog nqaij hlav qib siab uas tau muaj kev vam meej raws li qhov pib teb kev kho nrog PD-1 / PD-L1 chaw kuaj xyuas inhibitor kev kho. Txhua tus neeg mob yuav tau txais kev kho mob sib xyaw ntawm PD-1 / PD-L1 chaw kuaj mob ntxiv rau ALT-803 txog li 16 voj voog. Txhua lub voj voog yog rau lub lim tiam. Txhua tus neeg mob yuav tau txais ALT-803 ib zaug txhua 3 asthiv. Cov neeg mob tseem yuav tau txais tib qho kev kuaj mob uas lawv tau txais thaum lawv kho dhau los. Qhov ntsuas radiologic yuav tshwm sim thaum kawg ntawm txhua ntu kev kho mob. Kev kho mob yuav txuas ntxiv mus ntev txog 2 xyoos, lossis txog thaum tus neeg mob tau paub tias muaj kab mob kev nce qib lossis tsis tuaj yeem siv tshuaj lom, thim kev tso cai, lossis yog tias Tus Neeg Tshawb Nrhiav pom tau tias nws tsis yog qhov zoo rau tus neeg mob mus ntxiv kev kho mob. Cov neeg mob yuav raug ua raws li kev mob tshwm sim, kev kho mob tom qab, thiab kev muaj sia nyob dhau 24 lub hlis dhau los ntawm kev siv tshuaj rau thawj koob tshuaj.
Qhov chaw: 9 thaj chaw
Kev Tiv Thaiv Kev Nyab Xeeb, Kev Ncaj Ncees, Kev Siv Tshuaj Tiv Thaiv, thiab Antitumor Kev Ua Haujlwm ntawm GEN-009 Qhov Tshuaj Tiv Thaiv Kab Mob
Hauv txoj kev tshawb fawb no, Genocea tab tom soj ntsuam kev soj ntsuam, kev tiv thaiv tus kheej txuas nrog rau tus kheej, GEN-009, uas tau tsim kho rau cov neeg mob uas muaj cov qog ntshav. Cov cuab yeej uas tsim los ntawm Genocea, hu ua ATLAS ™ (Antigen Lead Acquisition System) yuav siv los txheeb xyuas neoantigens hauv txhua tus neeg mob qog uas tau lees paub los ntawm lawv cov CD4 thiab / lossis CD8 T. ATLAS-txheeb cov neoantigens yuav suav nrog kev txhaj tshuaj tiv thaiv tus neeg mob nyob rau hauv cov qauv ntawm cov khoom hluavtaws ntev (SLPs).
Qhov chaw: 9 thaj chaw
Kev Tshawb Fawb txog NKTR-262 hauv Kev Tiv Thaiv Nrog NKTR-214 thiab Nrog NKTR-214 Ntxiv Nivolumab hauv Cov Neeg Mob Nrog Kev Tshaj Tawm hauv zos lossis Metastatic Solid Tumor Malignancies
Cov neeg mob yuav tau txais mob plab-loj (IT) NKTR-262 hauv 3-lub lis piam mus kho mob. Thaum lub Sijhawm Theem 1 kev nce qib ntawm qhov kev sim, NKTR-262 yuav muab tso ua ke nrog kev tswj hwm ntawm bempegaldesleukin. Tom qab kev txiav txim siab pom zoo raws Ntu 2 koob (RP2D) ntawm NKTR-262, nruab nrab ntawm 6 thiab 12 tus neeg mob tuaj yeem raug sau npe ntawm RP2D txhawm rau txhawm rau txheeb xyuas qhov muaj kev nyab xeeb thiab tiv taus kev tiv thaiv ntawm kev sib xyaw NKTR 262 ntxiv rau bempegaldesleukin (doublet) lossis NKTR 262 ntxiv bempegaldesleukin txuam nrog nivolumab (triplet) hauv Cohorts A thiab B, feem. Hauv Ntu 2 nthuav dav zuj zus ntxiv, cov neeg mob yuav raug kho nrog doublet lossis triplet hauv qhov tso tawm / rov tso chaw kho mob thiab cov kab kev kho thaum ntxov.
Qhov chaw: 14 thaj chaw
Ib qho Kev Ntsuam Xyuas ntawm Pembrolizumab & Kev Ntsuas Xaj Xaim Hlawv Hluav Taws Xob Hluav Taws Xob rau hauv Kev Nyuaj Siab Hlaus Mob Mos Cov Hluav Taws Xob Sarcoma ntawm Kev Ua Yeeb Yam Loj
Qhov no yog qhib-daim ntawv lo, ntau lub koom haum theem II randomized kawm sib piv neoadjuvant radiotherapy ua raws li kev phais mob rov qab rau neoadjuvant pembrolizumab nrog kev kho hluav taws xob, ua raws kev phais mob phais thiab puvrolizumab. Tag nrho lub sijhawm ntawm pembrolizumab yuav yog ib xyoos nyob hauv kev sim ntawm caj npab.
Qhov chaw: 10 thaj chaw
Proton Beam lossis Photon-Raws Kev Nyuaj Siab-Kev Tsoo Hluav Taws Xob Kho Mob hauv Kev Kho Mob rau Cov Neeg Mob Nrog Kev Mob Ntshav Ntws lub qog nqaij hlav, mob qog nqaij hlav, lossis Melanoma
Qhov kev sim rau qib II no sim kawm txog kev phiv los sis sim cov duab hluav taws xob los kho duab hluav taws xob rau kev kho cov neeg mob uas muaj mob qog nqaij hlav cancer, mob qog nqaij hlav, lossis mob nqaij daim tawv nqaij. Proton beam hluav taws xob kho siv cov khoom sib tw me me los xa cov hluav taws xob ncaj qha mus rau cov qog thiab yuav ua kev puas tsuaj tsawg dua cov nqaij mos. Kev siv ntau los sis photon nqaj hluav taws xob kho siv hluav taws xob xoo hluav taws xob loj lub zog ua los kho cov qog thiab tseem yuav ua rau kev puas tsuaj tsawg dua rau cov ntaub so ntswg li qub. Nws tseem tsis tau paub yog tias lub cev tiv thaiv cov kab hluav taws xob ua haujlwm zoo dua li cov duab hluav taws xob photon-siv tshuaj kho hluav taws xob rau kev kho cov neeg mob uas muaj mob qog nqaij hlav cancer, mob qog nqaij hlav, lossis mob nqaij tawv.
Qhov chaw: 8 thaj chaw
Hauv Ntsej Muag Hluav Taws Xob Tawm Hauv Hlawv Hlawv Hauv Kev Kho Mob Cov Neeg Laus Dua uas nyuam qhuav raug kuaj pom ntxov ntxov ntawm tes tawv nqaij los yog ntsej muag qog nqaij hlav tawv
Qhov kev sim kho mob sim tshawb xyuas no zoo npaum li cas cov tawv nqaij hluav taws xob saum npoo tawv (ESSB) ua haujlwm hauv kev kho cov neeg laus uas nyuam qhuav muaj mob ntxov ntxov txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm los yog qog nqaij daim tawv nqaij. ESSB yog ib hom kev kho hluav taws xob uas siv cov neeg siv tawv nqaij los tso rau hauv qhov chaw siv hluav taws xob rau kev kho mob qog nqaij hlav. Daim tawv nqaij pleev cov rau saum npoo av yog puag ncig, cov ntsaws ntsej muag uas txuas nrog lub tshuab ua hluav taws xob, thiab muab cov hluav taws xob rau kev kho. ESSB tuaj yeem tso cai kho tus qog thaum tab tom ua rau cov nqaij mos noj qab haus huv tsis muaj kev puas tsuaj los ntawm hluav taws xob.
Qhov chaw: 8 thaj chaw
Stereotactic Lub Hlav Hluav Taws Xob Kho Mob Hauv Lub Cev Kev Kho Mob rau Cov Neeg Mob Qog Pob Txha Hluav Taws Xob nrog kev muaj mob tsawg ntawm kev kuaj xyuas lub cev
Qeb Kev Sim Qeb II no kawm txog kev kho lub cev lub cev ua haujlwm zoo li cas rau kev kho cov neeg mob qog noj ntshav uas tau kis mus rau lwm qhov chaw hauv lub cev nrog kev kho mob tsawg thaum nyob ntawm kev tiv thaiv kab mob tiv thaiv kab mob. Stereotactic lub cev hluav taws xob kho siv cov cuab yeej tshwj xeeb los muab tus neeg mob thiab xa cov hluav taws xob rau cov qog hlav nrog qhov ntsuas siab. Txoj kev no tuaj yeem tua cov qog nqaij hlav nrog cov koob tshuaj tsawg dua nyob rau lub sijhawm luv luv thiab ua rau cov ntaub so ntswg tsawg dua.
Qhov chaw: 7 thaj chaw
Cabozantinib S-malate thiab Cetuximab hauv Kev Kho Mob Rau Cov Neeg Mob Nrog Metastatic Taub Hau Thiab Caj Qog Hlaws Pob Cell
Qeb ib theem no kuv sim kawm txog cov kev mob tshwm sim thiab qhov zoo tshaj plaws ntawm cabozantinib S-malate thiab thaum muab ua ke nrog cetuximab hauv kev kho mob rau cov neeg mob qog taub hau thiab caj dab qog ua cancer tau kis mus rau lwm qhov chaw hauv lub cev. Cabozantinib S-malate tuaj yeem ua rau qeeb kev loj hlob ntawm cov qog nqaij hlav cancer los ntawm kev txiav cov ntshav txaus uas tus mob cancer xav tau kev ciaj sia thiab loj hlob. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li cetuximab, tej zaum yuav ua rau muaj kev hloov pauv hauv lub cev tiv thaiv kab mob hauv lub cev thiab yuav cuam tshuam nrog kev muaj peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Muab cabozantinib S-malate thiab cetuximab tuaj yeem ua haujlwm zoo dua hauv kev kho mob rau cov neeg mob qog nqaij hlav taub hau thiab caj dab.
Qhov chaw: 7 thaj chaw
Kev Nyab Xeeb, Kev Tsim Nyog Ua Ntej thiab PK ntawm Isatuximab (SAR650984) Ib leeg lossis hauv Sib Ntxiv Nrog Atezolizumab hauv Cov Neeg Mob Nrog Kev Kho Mob Malignancies
Lub Hom Phiaj Tseem Ceeb: - Txheej Txheem 1: Txhawm rau ua kom muaj kev nyab xeeb thiab thev taus ntawm isatuximab hauv kev sib xyaw nrog kev noj zaub mov noj hauv cov neeg koom nrog kev tiv thaiv kab mob siab tsis haum (HCC), platinum-refractory recurrent / metastatic squamous cell carcinoma ntawm lub taub hau thiab caj dab (SCCHN), platinum-resistant / refractory epithelial ntawm zes qe menyuam mob qog nqaij hlav (EOC), lossis rov ua dua qub glioblastoma multiforme (GBM), thiab txhawm rau txiav txim siab pom zoo Theem 2 koob tshuaj (RP2D). - Theem 2: txhawm rau ntsuas tus nqi teb (RR) ntawm isatuximab sib xyaw nrog kev noj mov uake nyob rau hauv koom nrog HCC lossis SCCHN lossis EOC. - Qeb 2: Txheeb xyuas qhov nce zuj zus tsis pub muaj sia nyob ntev li ntawm 6 lub hlis (PFS-6) ntawm isatuximab ntau ntxiv nrog rau nojzolizumab, lossis raws li ib tus neeg sawv cev hauv koom nrog GBM. Lub Hom Phiaj Thib Ob: - Txheeb xyuas qhov muaj kev nyab xeeb ntawm isatuximab monotherapy (GBM nkaus xwb), los yog hauv kev sib xyaw nrog kev noj zaub mov noj hauv Theem 2. - Yuav kom ntsuas lub immunogenicity ntawm isatuximab thiab Eatzolizumab. - Txhawm rau ua kom qhov txawv ntawm tus kws kho mob (PK) profile ntawm isatuximab ib tus neeg sawv cev (GBM nkaus xwb) thiab tau noj cov zaub mov sib xyaw nrog isatuximab. - Txhawm rau txhawm rau qhov kev ua tau zoo ntawm isatuximab ntau ntxiv nrog rau Eatzolizumab, lossis ib tus neeg sawv cev (GBM nkaus xwb).
Qhov chaw: 7 thaj chaw
Kev Tshawb Fawb ntawm INCMGA00012 hauv Metastatic Merkel Cell Carcinoma (POD1UM-201)
Lub hom phiaj ntawm cov kev tshawb fawb no yog txhawm rau soj ntsuam cov kev ua haujlwm hauv chaw kho mob thiab kev nyab xeeb ntawm INCMGA00012 hauv cov koom nrog cov neeg mob siab / mob siab rau Merkel cell carcinoma (MCC).
Qhov chaw: 8 thaj chaw
Lenvatinib Mesylate thiab Cetuximab hauv Kev Kho Mob rau Cov Neeg Mob Nrog Kev Mob Rov Qab los yog Pob Tawb Lub taub hau thiab caj dab caj dab Cell Carcinoma lossis Cutaneous Squamous Cell Carcinoma
Lub sijhawm I / Ib sim no kawm txog qhov zoo tshaj plaws thiab qhov tshwm sim ntawm lenvatinib mesylate thiab cetuximab hauv kev kho cov neeg mob taub hau thiab caj dab squamous cell carcinoma lossis cutaneous squamous cell carcinoma uas tau rov qab los (ib qho zuj zus) lossis kis mus rau lwm qhov chaw hauv lub cev (metastatic) )). Lenvatinib mesylate tuaj yeem nres kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes xav tau rau kev loj hlob ntawm tes. Cov tshuaj tiv thaiv monoclonal, xws li cetuximab, tuaj yeem cuam tshuam kev muaj peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Muab lenvatinib mesylate thiab cetuximab yuav ua haujlwm zoo dua rau kev kho mob rau cov neeg mob taub hau thiab caj dab squamous cell carcinoma lossis cutaneous squamous cell carcinoma.
Qhov chaw: 7 thaj chaw
PEN-221 hauv Somatostatin Receptor 2 nthuav qhia Qog Kuaj Qib Kuaj Dua Ntxiv Nrog Rau Neuroendocrine thiab Cov Nqaij Hlawv Me Ntshav PEN-221-001 yog qhov qhib-cim, multicenter Theem 1 / 2a kawm ntsuas PEN-221 hauv cov neeg mob nrog SSTR2 qhia txog kev mob plab hnyuv taum (GEP) lossis mob ntsws los yog thymus lossis lwm cov qog neuroendocrine los yog mob qog nqaij hlav cancer me lossis mob cell loj neuroendocrine carcinoma ntawm lub ntsws.
Qhov chaw: 7 thaj chaw
1 2 3 4 5 Tom ntej no> Lub Chaw Kuaj Mob Hauv Tebchaws
