Txog-mob cancer / kho mob / kuaj mob-sim / mob / merkel-ntawm tes / kev kho mob
Kho Tej Chaw Kho Mob rau Merkel Cell Cancer
Cov chaw kuaj mob yog cov kev tshawb fawb tshawb fawb uas cuam tshuam nrog tib neeg. Cov kev sim tshuaj rau cov npe no yog rau Merkel kev kho mob cancer ntawm tes. Txhua qhov kev sim ntawm daim npe tau txhawb los ntawm NCI.
NCI cov ncauj lus tseem ceeb txog kev sim kho mob piav qhia txog ntau hom thiab ncua sij hawm ntawm kev sim thiab seb lawv raug coj los ua li cas. Cov chaw soj ntsuam kuaj xyuas txoj hauv kev tshiab los tiv thaiv, kuaj pom, lossis kho kab mob. Tej zaum koj yuav xav xav txog kev koom tes hauv kev sim tshuaj kuaj mob. Tham nrog koj tus kws kho mob kom pab txiav txim siab yog tias ib qho zoo rau koj.
Kev Txom Nyem 1-25 ntawm 32 1 2 Tom ntej>
Pembrolizumab piv rau Txuj Ci Kev Saib Xyuas hauv Kev Kho Mob rau Cov Neeg Mob Nrog Tus Mob Zoo Thib I-III Merkel Cell Cancer
Kev sim qib III no tshawb xyuas seb pembrolizumab ua haujlwm zoo npaum li cas piv rau kev saib xyuas kev saib xyuas hauv kev kho mob rau cov neeg mob theem I-III Merkel cell uas raug tshem tawm los ntawm kev phais mob (rov ua haujlwm dua). Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li pembrolizumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Qhov chaw: 286 qhov chaw
Pembrolizumab nrog lossis tsis Stereotactic Lub Hlav Hluav Taws Xob Kho Mob hauv Kev Kho Mob rau Cov Neeg Mob Muaj Qib Tshaj Plaws lossis Metastatic Merkel Cell
Qhov kev sim kho nyob rau qib II no sim saib pembrolizumab tau zoo npaum li cas nrog lossis tsis muaj kev kho lub cev ntawm lub cev ua haujlwm rau kev kho cov neeg mob Merkel cell cancer uas tau kis mus rau lwm qhov chaw hauv lub cev. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li pembrolizumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Stereotactic lub cev hluav taws xob kho siv cov cuab yeej tshwj xeeb los muab tus neeg mob thiab xa cov hluav taws xob rau cov qog hlav nrog qhov ntsuas siab. Txoj kev no tuaj yeem tua cov qog nqaij hlav nrog cov koob tshuaj tsawg dua nyob rau lub sijhawm luv luv thiab ua rau cov ntaub so ntswg tsawg dua. Kev muab pembrolizumab nrog txoj kev kho mob lub cev stereotactic hluav taws xob tuaj yeem ua haujlwm zoo dua hauv kev kho mob rau cov neeg mob Merkel cell.
Qhov chaw: 246 thaj chaw
Qhov Kev Tshawb Nrhiav Kev Siv Tshuaj Tiv Thaiv Kev Tshawb Fawb los tshawb nrhiav qhov kev nyab xeeb thiab ua tau zoo ntawm Nivolumab, thiab Nivolumab Txoj Kev Kho Mob Nkag mus rau hauv kev mob qog
Lub hom phiaj ntawm txoj kev kawm no los tshawb txog kev nyab xeeb thiab kev ua tau zoo ntawm nivolumab, thiab kev kho nivolumab ua ke, los kho cov neeg mob uas muaj cov qog ua hlav. Qee cov kab mob tau paub ua lub luag haujlwm hauv kev tsim cov qog thiab kev loj hlob. Qhov kev tshawb nrhiav no yuav tshawb txog qhov tshwm sim ntawm cov tshuaj kawm, hauv cov neeg mob uas muaj cov qog loj hauv qab no: - Khees-xaws quav tawm lub qhov quav-Tsis tso npe rau hom mob qog nqaij hlav no - Cervical cancer - Epstein Barr Virus (EBV) zoo mob qog noj ntshav-tsis tuaj yeem sau npe no hom qog nqaij hlav - Merkel Cell Cancer - mob qog nqaij hlav cancer-Tsis teev npe rau hom qog nqaij hlav no - Vaginal thiab vulvar cancer-Tsis tso npe rau hom mob qog no - Nasopharyngeal Cancer - Tsis tso npe rau hom qog nqaij hlav ntxiv - Mob Tawv Hau thiab Caj Dab - Tsis tso npe rau hom mob no ntxiv lawm
Qhov chaw: 10 thaj chaw
Txoj Kev Tshawb Fawb Qhov no Tshuaj Ntsuam Xyuas KRT-232, Qhov Tshiab Tshiab Qhov Ntshav Me Nyuam Mos Cov Hluav Taws Xob ntawm MDM2, rau Kev Kho Mob Rau Cov Neeg Mob Nrog (p53WT) Merkel Cell Carcinoma Leej Twg Ua Tsis Tau Zoo los tiv thaiv PD-1 / PD-L1 Immunotherapy
Txoj kev tshawb no soj ntsuam KRT-232, ib qho tshiab ntawm qhov ncauj me me molecule inhibitor ntawm MDM2, rau kev kho mob ntawm cov neeg mob Merkel Cell Carcinoma (MCC) uas tsis ua tiav kev kho mob nrog tsawg kawg ib qho tshuaj tiv thaiv PD-1 lossis tiv thaiv PD-L1. Kev Txwv tsis pub MDM2 yog qhov kev tawm tswv yim tshiab ntawm kev nqis tes hauv MCC. Txoj kev tshawb no yog ntu 2, Qhib-Label, Ib Sab Caj npab ntawm KRT-232 hauv cov neeg mob nrog p53 Tsiaj qus hom (p53WT) Merkel Cell Carcinoma
Qhov chaw: 11 thaj chaw
Adjuvant Avelumab hauv Merkel Cell Cancer
Qhov kev sim rau qib III no sim tshawb xyuas seb cov avelumab ua haujlwm zoo li cas rau kev kho cov neeg mob Merkel cell mob cancer uas tau kis mus rau cov qog ntshav thiab tau phais mob nrog lossis tsis muaj kev kho mob hluav taws xob. Cov tshuaj tiv thaiv monoclonal, xws li avelumab, tuaj yeem txhawb lub zog tiv thaiv kab mob thiab cuam tshuam nrog kev muaj peev xwm ntawm cov qog ntshav hlav kom loj hlob thiab kis tau.
Qhov chaw: 10 thaj chaw
QUILT-3.055: Kev Tshawb Fawb txog ALT-803 hauv Kev Tshawb Xyuas Nrog PD-1 / PD-L1 Cov Chaw Soj Ntsuam hauv cov neeg mob uas muaj Kab Mob Qib Siab
Qhov no yog Ntu IIb, ib sab tes, ntau, ib qho qhib daim ntawv lo qhia ntau txoj kev kawm ntawm ALT-803 nrog kev pom zoo ntawm FDA-pom zoo PD-1 / PD-L1 cov tshuaj ntsuam xyuas hauv cov neeg mob uas muaj mob qog nqaij hlav qib siab uas tau muaj kev vam meej raws li qhov pib teb kev kho nrog PD-1 / PD-L1 chaw kuaj xyuas inhibitor kev kho. Txhua tus neeg mob yuav tau txais kev kho mob sib xyaw ntawm PD-1 / PD-L1 chaw kuaj mob ntxiv rau ALT-803 txog li 16 voj voog. Txhua lub voj voog yog rau lub lim tiam. Txhua tus neeg mob yuav tau txais ALT-803 ib zaug txhua 3 asthiv. Cov neeg mob tseem yuav tau txais tib qho kev kuaj mob uas lawv tau txais thaum lawv kho dhau los. Qhov ntsuas radiologic yuav tshwm sim thaum kawg ntawm txhua ntu kev kho mob. Kev kho mob yuav txuas ntxiv mus ntev txog 2 xyoos, lossis txog thaum tus neeg mob tau paub tias muaj kab mob kev nce qib lossis tsis tuaj yeem siv tshuaj lom, thim kev tso cai, lossis yog tias Tus Neeg Tshawb Nrhiav pom tau tias nws tsis yog qhov zoo rau tus neeg mob mus ntxiv kev kho mob. Cov neeg mob yuav raug ua raws li kev mob tshwm sim, kev kho mob tom qab, thiab kev muaj sia nyob dhau 24 lub hlis dhau los ntawm kev siv tshuaj rau thawj koob tshuaj.
Qhov chaw: 9 thaj chaw
Kev Tshawb Fawb txog NKTR-262 hauv Kev Tiv Thaiv Nrog NKTR-214 thiab Nrog NKTR-214 Ntxiv Nivolumab hauv Cov Neeg Mob Nrog Kev Tshaj Tawm hauv zos lossis Metastatic Solid Tumor Malignancies
Cov neeg mob yuav tau txais mob plab-loj (IT) NKTR-262 hauv 3-lub lis piam mus kho mob. Thaum lub Sijhawm Theem 1 kev nce qib ntawm qhov kev sim, NKTR-262 yuav muab tso ua ke nrog kev tswj hwm ntawm bempegaldesleukin. Tom qab kev txiav txim siab pom zoo raws Ntu 2 koob (RP2D) ntawm NKTR-262, nruab nrab ntawm 6 thiab 12 tus neeg mob tuaj yeem raug sau npe ntawm RP2D txhawm rau txhawm rau txheeb xyuas qhov muaj kev nyab xeeb thiab tiv taus kev tiv thaiv ntawm kev sib xyaw NKTR 262 ntxiv rau bempegaldesleukin (doublet) lossis NKTR 262 ntxiv bempegaldesleukin txuam nrog nivolumab (triplet) hauv Cohorts A thiab B, feem. Hauv Ntu 2 nthuav dav zuj zus ntxiv, cov neeg mob yuav raug kho nrog doublet lossis triplet hauv qhov tso tawm / rov tso chaw kho mob thiab cov kab kev kho thaum ntxov.
Qhov chaw: 14 thaj chaw
Kev Tshawb Fawb ntawm INCMGA00012 hauv Metastatic Merkel Cell Carcinoma (POD1UM-201)
Lub hom phiaj ntawm cov kev tshawb fawb no yog txhawm rau soj ntsuam cov kev ua haujlwm hauv chaw kho mob thiab kev nyab xeeb ntawm INCMGA00012 hauv cov koom nrog cov neeg mob siab / mob siab rau Merkel cell carcinoma (MCC).
Qhov chaw: 8 thaj chaw
PEN-221 hauv Somatostatin Receptor 2 Qhia Qog Ua Kuaj Tshaj Plaws Nrog Cov Neuroendocrine thiab Cov Ntshav Qog Cell Kuaj
Raws tu qauv PEN-221-001 yog qhib-cim, multicenter Ntu 1 / 2a kawm ntsuas PEN-221 rau cov neeg mob SSTR2 qhia txog kev mob siab rau txoj hnyuv (GEP) lossis lub ntsws lossis thymus lossis lwm cov qog nqaij hlav hauv neuroendocrine los yog mob qog nqaij hlav ntshav me ntawm lub ntsws.
Qhov chaw: 7 thaj chaw
Ib Ntu 1/2 Txoj Kev Tshawb Fawb ntawm Situ Qhov Tshuaj Tiv Thaiv Nrog Tremelimumab thiab IV Durvalumab Ntxiv PolyICLC hauv Cov Ntsiab Lus Nrog Kev Tshaj Lij, Ntsuas ntsuas, nqaij hlav-nkag mus rau cov qog nqaij hlav
Qhov no yog qhib-daim ntawv lo, multicenter Theem 1/2 kawm txog CTLA-4 antibody, tremelimumab, thiab PD-L1 antibody, durvalumab (MEDI4736), ua ke nrog cov qog microenvironment (TME) modulator polyICLC, a TLR3 agonist, hauv cov kev kawm nrog kev tshaj lij, ntsuas tau, nqaij qog nqaij-nkag tau los ntawm qog nqaij hlav.
Qhov chaw: 6 thaj chaw
Intratumoral AST-008 Sib xyaw Nrog Pembrolizumab hauv Cov Neeg Mob Nrog Cov Qog Ua Tau Zoo
Qhov no yog ntu 1b / 2, qhib-daim ntawv lo, ntau qhov kev sib hais tsim los soj ntsuam kev nyab xeeb, kev tiv taus, cov chaw muag tshuaj, kws tshuaj thiab ua kom tau txais txiaj ntsig ntawm kev txhaj tshuaj AST-008 txhaj ib leeg thiab hauv kev sib xyaw nrog cov leeg pembrolizumab hauv cov neeg mob uas muaj cov qog ua ntej. Lub sijhawm 1b ntawm qhov kev sim no yog 3 + 3 koob tshuaj tiv thaiv kev kawm soj ntsuam kev nce lossis nce ib nrab ntawm qib AST-008 uas muab nrog cov koob pembrolizumab. Ntu 2 yog kev nthuav qhia ntxiv txhawm rau soj ntsuam ntxiv AST-008 muab nrog pembrolizumab hauv cov pejxeem tshwj xeeb los muab qhov kev kwv yees ua ntej tau txais txiaj ntsig zoo rau cov neeg mob uas tau txais yav tas los thiab tsis teb los tiv thaiv PD-1 lossis tiv thaiv PD-L1 cov tshuaj tiv thaiv. kev kho.
Qhov chaw: 7 thaj chaw
Kev Tshawb Fawb ntawm Intratumoral Txhaj Tshuaj TTI-621 hauv Cov Neeg Kawm Nrog Relapsed thiab Refractory Cov Khoom Siv Tawv Thiab Mycosis Fungoides
Nov yog qhov chaw ua haujlwm ntau, qhib-daim ntawv lo, theem 1 kev kawm ua qhov kev sim txhawm rau kuaj kev txhaj tshuaj ntawm TTI-621 hauv cov ncauj lus uas tau rov ua haujlwm thiab rov tuaj yeem tuaj yeem tau txais cov qog ntshav lossis mycosis fungoides. Txoj kev kawm no yuav ua rau ob qhov sib txawv. Ntu 1 yog The Dose Escalation theem thiab Tshooj 2 yog The Dose Expansion theem. Lub hom phiaj ntawm cov kev tshawb fawb no yog txhawm rau paub qhov muaj tseeb kev nyab xeeb ntawm TTI-621 thiab los txiav txim siab qhov zoo tshaj plaws koob tshuaj thiab kev xa khoom ntawm TTI-621. Tsis tas li ntawd, kev nyab xeeb thiab antitumor kev ua haujlwm ntawm TTI-621 yuav raug soj ntsuam hauv kev sib xyaw nrog lwm cov kab mob tiv thaiv qog ntshav lossis hluav taws xob.
Qhov chaw: 5 thaj chaw
Txoj kev kawm ntawm RP1 Kev Kho Mob Tshuaj thiab Kho Mob RP1 hauv Kev Sib xyaw Nrog Nivolumab
RPL-001-16 yog Ntu 1/2, qhib daim ntawv lo, koob tshuaj tiv thaiv kab mob thiab nthuav dav hauv kev tshawb fawb ntawm RP1 ib leeg thiab kev sib xyaw nrog nivolumab hauv cov neeg laus kawm nrog qib siab thiab / lossis refractory cov qog, txhawm rau txiav txim siab ntau tshaj plaws koob tshuaj (MTD) thiab pom zoo rau Theem 2 koob tshuaj (RP2D), nrog rau tshuaj xyuas ua ntej ua tau zoo.
Qhov chaw: 6 thaj chaw
Talimogene Laherparepvec nrog lossis tsis muaj Hypofractionated Hluav Taws Xob Kho Kev Kho Mob hauv Kev Kho Cov Neeg Mob Nrog Metastatic Melanoma, Merkel Cell Carcinoma, lossis Lwm Yam Khoom Lub Pob.
Qhov kev sim rau qib II no sim cov kev mob tshwm sim ntawm talimogene laherparepvec thiab pom tias nws ua haujlwm zoo npaum li cas nrog lossis tsis muaj kev kho mob hypofractionated hluav taws xob hauv kev kho mob rau cov neeg mob tawv nqaij melanoma, Merkel cell carcinoma, lossis lwm yam qog uas tau kis mus rau qhov chaw tsis tsim nyog rau kev phais mob Cov. Cov tshuaj siv rau hauv kev siv tshuaj tiv thaiv kab mob, xws li talimogene laherparepvec, tuaj yeem txhawb lub cev tiv thaiv kab mob hauv lub cev kom tua cov qog hlwb. Hypofractionated hluav taws xob kev kho mob muab ntau dua cov tshuaj kho hluav taws xob ntau dua lub sijhawm luv dua thiab yuav tua cov qog ua qog ntau dua thiab muaj kev phiv tshuaj tsawg dua. Nws tseem tsis tau paub yog tias muab cov tshuaj talimogene laherparepvec nrog lossis tsis muaj tshuaj tua kabmob hypofractionated yuav ua haujlwm zoo dua rau kev kho cov neeg mob qog nqaij hlav melanoma, Merkel cell carcinoma, lossis cov qog ua pob.
Qhov chaw: 3 thaj chaw
FT500 raws li Kev Kho Mob Liab thiab hauv Kev Sib xyaw Nrog Cov Chaw Tshuaj Tiv Thaiv Txheem Zog Hauv Cov Tshuaj Txhim Kho nrog Cov Qog Tshaj Plaws Qib Dua
FT500 yog qhov tawm ntawm cov khoom lag luam, iPSC-tau ua NK NK khoom lag luam uas tuaj yeem txuas innate thiab hloov kev tiv thaiv kev tiv thaiv, thiab muaj lub peev xwm los kov yeej ntau yam kev tiv thaiv kab mob ntawm cov tshuaj tiv thaiv kab mob tiv thaiv kab mob (ICI) tsis kam. Cov ntaub ntawv preclinical muab cov pov thawj ua pov thawj txhawb kev tshawb fawb soj ntsuam ntawm FT500 raws li kev kho mob monotherapy thiab hauv kev sib xyaw nrog ICI hauv cov ncauj lus nrog cov qog ua cov qog dhau los.
Qhov chaw: 3 thaj chaw
Tacrolimus, Nivolumab, thiab Ipilimumab hauv Kev Kho Mob Lub raum Hloov Cov Neeg Tau Txais los ntawm Kev Xaiv tsis tau tus mob lossis hom mob qog nqaij hlav
Qeb ib qib no kuv sim kawm seb tacrolimus, nivolumab, thiab ipilimumab ua haujlwm rau cov neeg tau txais lub raum mob qog nqaij hlav uas tsis tuaj yeem raug tshem tawm los ntawm kev phais mob (tsis tuaj yeem tiv thaiv) lossis tau kis mus rau lwm qhov chaw hauv lub cev (metastatic). Tacrolimus tuaj yeem nres kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes xav tau rau kev loj hlob ntawm tes. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab thiab ipilimumab, tuaj yeem pab lub cev tiv thaiv kab mob tua lub qog ntshav, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau. Muab cov tacrolimus, nivolumab, thiab ipilimumab tuaj yeem ua haujlwm zoo dua rau kev kho cov neeg mob raum nrog rau mob qog nqaij hlav piv rau kev siv tshuaj kho mob, phais mob, siv hluav taws xob, lossis kho hom phiaj.
Qhov chaw: 2 thaj chaw
Nivolumab thiab Ipilimumab nrog lossis tsis muaj Lub Cev Stereotactic Lub Hlav Hluav Taws Xob Kho Mob hauv Kev Kho Mob rau Cov Neeg Mob Rov Qab los sis Theem IV Merkel Cell Cancer
Qhov kev sim rau qib II no sim tshawb xyuas seb nivolumab zoo li cas thiab ipilimumab nrog lossis tsis muaj lub zog ntawm lub cev kev kho mob ua haujlwm hauv kev kho cov neeg mob Merkel cell mob uas tau rov qab los yog theem IV. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab thiab ipilimumab, tuaj yeem pab lub cev tiv thaiv kab mob tua lub qog ntshav, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau. Stereotactic lub cev hluav taws xob kho siv cov cuab yeej tshwj xeeb los muab tus neeg mob thiab xa cov hluav taws xob rau cov qog hlav nrog qhov ntsuas siab. Txoj kev no tuaj yeem tua cov qog nqaij hlav nrog cov koob tshuaj tsawg dua nyob rau lub sijhawm luv luv thiab ua rau cov ntaub so ntswg tsawg dua. Muab nivolumab thiab ipilimumab nrog lossis tsis muaj lub zog ntawm lub cev kev kho mob lub cev yuav ua haujlwm zoo dua rau kev kho mob rau cov neeg mob Merkel cell.
Qhov chaw: 2 thaj chaw
Pembrolizumab thiab Kev Kuaj Hluav Taws Xob rau Kev Kho Mob ntawm Metastatic Merkel Cell Carcinoma
Kev sim qib II no kawm txog cov kev mob tshwm sim thiab zoo npaum li cas pembrolizumab thiab tshuaj tua hluav taws xob ua haujlwm hauv kev kho cov neeg mob Merkel cell carcinoma uas tau kis mus rau lwm qhov chaw hauv lub cev (metastatic). Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li pembrolizumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Kev siv hluav taws xob tua hluav taws xob yog siv hluav taws xob ntau xoo hluav taws xob tua cov qog thiab ua cov qog. Kev muab pembrolizumab thiab tshuaj kho hluav taws xob yuav ua rau kom muaj txiaj ntsig pembrolizumab ntau.
Qhov Chaw: Stanford Cancer Institute Palo Alto, Palo Alto, California
Kev Tshawb Fawb ntawm LY3434172, PD-1 thiab PD-L1 Bispecific Antibody, hauv Kev Mob Khov Kho Mob Qib Siab
Lub hom phiaj tseem ceeb ntawm txoj kev tshawb no yog txhawm rau soj ntsuam qhov kev nyab xeeb thiab kev ua siab ntev ntawm kev kawm txog cov tshuaj LY3434172, PD-1 / PD-L1 bispecific antibody, hauv cov neeg koom nrog cov qog ua kom zoo.
Qhov Chaw: MD Anderson Cancer Center, Houston, Texas
Kev Kho Mob Ntawm Lub Hlwb (Tumor Infiltrating Lymphocytes) rau Kev Kho Mob ntawm Kev Siv Hauv Ib Cheeb Tsam, Tshaj Loj, lossis Kev Thooj Quav Qog Hlawv
Kev sim qib II no kawm txog kev kho mob cell zoo li cas (nrog rau cov qog ua mob lymphocytes) ua haujlwm rau kev kho mob qog nqaij hlav uas tau kis mus rau cov nqaij lossis cov qog ntshav (nyob ze hauv ib cheeb tsam), tau kis mus rau lwm qhov ntawm lub cev (metastatic), lossis muaj rov qab los (rov muaj dua). Qhov kev sim no suav nrog kev noj cov cell hu ua lymphocytes (ib hom qe ntshav dawb) los ntawm cov qog neeg mob, hlav tuaj rau hauv chav kuaj tshuaj kuaj cov coob, thiab tom qab ntawd muab cov qog rov qab rau tus neeg mob. Cov hlwb no yog hu ua qog ua mob lymphocytes thiab kev kho yog hu ua kev kho cell. Muab cov tshuaj tua kab mob ua ntej lub hlwb yuav txiav txim ib ntus ua rau lub cev tiv thaiv kab mob txhawm rau txhim kho txoj hauv kev uas cov qog ua haujlwm tua cov hlwb yuav muaj sia nyob hauv lub cev. Muab cov tshuaj aldesleukin tom qab kev tswj hwm ntawm tes yuav pab cov qog ua hlav ua lub neej ntev dua.
Qhov Chaw: University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
Nivolumab thiab Kev Kuaj Mob Hlaws Hlaws lossis Ipilimumab li Adjuvant Kev Kho Mob hauv Kev Kho Tus Neeg Mob Merkel Cell Cancer
Qeb no Kuv sim kawm txog cov kev mob tshwm sim thiab zoo npaum li cas nivolumab ua haujlwm thaum muab ua ke nrog kev kho hluav taws xob lossis ipilimumab raws li kev kho mob nyob rau hauv kev kho cov neeg mob Merkel cell qog nqaij hlav. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab thiab ipilimumab, tuaj yeem pab lub cev tiv thaiv kab mob tua lub qog ntshav, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau. Kev siv hluav taws xob tua hluav taws xob yog siv hluav taws xob ntau x-ray, gamma rays, neutrons, protons lossis lwm qhov chaw los tua cov qog thiab ua cov qog. Muab nivolumab nrog kev kho hluav taws xob lossis ipilimumab tom qab phais tas yuav tua cov qog uas tseem tshuav.
Qhov Chaw: Ohio Lub Tsev Kawm Ntawv Qib Siab Lub Chaw Kuaj Mob Cancer, Columbus, Ohio
Pembrolizumab (MK-3475) raws li Kev Kho Mob Ua Ntej rau Cov Poj Niam Kho Mob Khov Kho Mob (Advanced Merkel Cell Carcinoma) (MK-3475-913)
Qhov no yog ib txhais caj npab, qhib-daim ntawv lo, multicenter, ua tau zoo, thiab kev kawm txog kev nyab xeeb ntawm pembrolizumab rau cov neeg laus thiab cov kws kho mob nrog cov tsis tau kawm txog Merkel Cell Carcinoma (MCC). Lub hom phiaj tseem ceeb ntawm kev sim yog ntsuam xyuas lub hom phiaj cov lus teb, raws li tau ntsuas los ntawm qhov muag tsis pom kev sab nraud ntawm qhov kev tshuaj ntsuam xyuas ntawm Cov Lus Teb Kev Ntsuas Cov Khoom Ntawm Cov Qog Cov Qauv 1.1 (RECIST 1.1) hloov kho kom ua raws qhov siab kawg ntawm 10 lub hom phiaj thiab qhov siab kawg ntawm 5 lub hom phiaj ib qho khoom nruab nrog, ua raws li kev tswj hwm ntawm pembrolizumab.
Qhov chaw: Laura thiab Isaac Perlmutter Cancer Center ntawm NYU Langone, New York, New York
Lub Cev Hloov Kho Cov Kab Mob Hlav (FH-MCVA2TCR) hauv Kev Kho Mob Rau Cov Neeg Mob Uas Muaj Metastatic lossis tsis tuaj yeem tsis mob Merkel Cell Cancer
Theem I / II kev sim no kawm txog kev phiv los ntawm cov hloov kho cov qe ntshav muaj zog tiv thaiv kab mob (FH-MCVA2TCR) thiab pom tias lawv ua haujlwm zoo npaum li cas rau kev kho cov neeg mob Merkel cell mob uas kis mus rau lwm qhov ntawm lub cev (metastatic) lossis qhov ntawd tsis tuaj yeem raug tshem tawm los ntawm kev phais mob (tsis tuaj yeem tiv thaiv). Tso cov noob uas tau tsim hauv chav kuaj mus rau hauv cov kab mob tiv thaiv kab mob hauv lub cev tuaj yeem txhim kho lub cev kev muaj peev xwm tiv thaiv Merkel cell cancer.
Qhov chaw nyob: Fred Hutch / Tsev Kawm Ntawv Qib Siab Washington Cancer Consortium, Seattle, Washington
Qhov Kev Nyab Xeeb thiab Kev Nyab Xeeb ntawm INCAGN02390 hauv Xaiv Advanced Malignancies
Lub hom phiaj ntawm qhov kev kawm no yog txiav txim siab txog kev nyab xeeb, tiv taus, thiab kev ua tau zoo ua ntej ntawm INCAGN02390 hauv cov koom nrog cov xaiv cov neeg ua haujlwm siab.
Qhov chaw: Hackensack University Medical Center, Hackensack, New Jersey
Abexinostat thiab Pembrolizumab hauv Kev Kho Mob Rau Cov Neeg Mob nrog MSI-Qib Loj hauv zos lossis Kev Ntsuas Zoo Tshaj Plaws
Qeb no Kuv sim kawm txog qhov zoo tshaj plaws thiab qhov tshwm sim ntawm abexinostat thiab nws zoo npaum li cas ua haujlwm nrog muab ua ke nrog pembrolizumab hauv kev kho cov neeg mob nrog microsatellite instability (MSI) cov qog ua haujlwm uas tau kis mus rau cov nqaij lossis cov qog ntshav (ze hauv zos) lossis lwm qhov chaw hauv lub cev (metastatic). Abexinostat yuav tso tseg txoj kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes uas xav tau rau kev loj hlob ntawm tes. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li pembrolizumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Kev muab tshuaj abexinostat thiab pembrolizumab tuaj yeem ua haujlwm zoo dua rau kev kho cov neeg mob qog ua pob.
Chaw: UCSF Medical Center-Mount Xi-oos, San Francisco, California
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