Txog-mob cancer / kho mob / soj ntsuam-sim / mob / mob pob ntseg / mob ntshav dawb / kho mob
Kev Kho Tej Chaw Kuaj Mob rau Cov Tshuaj Tiv Thaiv Mob Hlwb Melanoma
Cov chaw kuaj mob yog cov kev tshawb fawb tshawb fawb uas cuam tshuam nrog tib neeg. Kev kuaj mob hauv cov npe no yog rau kev kho mob melanoma. Txhua qhov kev sim ntawm daim npe tau txhawb los ntawm NCI.
NCI cov ncauj lus tseem ceeb txog kev sim kho mob piav qhia txog ntau hom thiab ncua sij hawm ntawm kev sim thiab seb lawv raug coj los ua li cas. Cov chaw soj ntsuam kuaj xyuas txoj hauv kev tshiab los tiv thaiv, kuaj pom, lossis kho kab mob. Tej zaum koj yuav xav xav txog kev koom tes hauv kev sim tshuaj kuaj mob. Tham nrog koj tus kws kho mob kom pab txiav txim siab yog tias ib qho zoo rau koj.
Kev sim 1-25 ntawm 25
Kev Nyab Xeeb thiab Kev Ua Tau Zoo ntawm IMCgp100 Versus Tus Kws Tshawb Xyuas Xaiv hauv Advanced Uveal Melanoma
Txheeb xyuas txhua qhov muaj sia nyob ntawm HLA-A * 0201 zoo tus neeg laus cov neeg mob uas tsis tau txais kev kho dua UM tau txais IMCgp100 piv rau Tus Kws Tshawb Fawb Xaiv ntawm dacarbazine, ipilimumab, lossis pembrolizumab.
Qhov chaw: 19 thaj chaw
Kev Tshawb Fawb Txog XmAb®22841 Kev Kho Mob Kho Mob & hauv Kev Sib txuam w / Pembrolizumab hauv Cov Ntsiab Lus w / Xaiv Cov Khoom Siv Tau Zoo Qog
Qhov no yog Ntu 1, ntau koob tshuaj, nce toj-koob tshuaj tiv thaiv kev kawm thiab nthuav dav kev kawm tsim los txhais qhov ntau tshaj plaws zam koob tshuaj thiab / lossis pom zoo koob tshuaj XmAb22841 monotherapy thiab hauv kev sib xyaw nrog pembrolizumab; txhawm rau ntsuas kev nyab xeeb, tiv taus siab, pharmacokinetics, tiv thaiv kab mob, thiab tiv thaiv qog ua haujlwm ntawm XmAb22841 monotherapy thiab ua ke nrog pembrolizumab hauv cov ntsiab lus nrog xaiv cov qog ua ntej.
Qhov chaw: 10 thaj chaw
Txoj kev kawm ntawm RP1 Kev Kho Mob Tshuaj thiab Kho Mob RP1 hauv Kev Sib xyaw Nrog Nivolumab
RPL-001-16 yog Ntu 1/2, qhib daim ntawv lo, koob tshuaj tiv thaiv kab mob thiab nthuav dav hauv kev tshawb fawb ntawm RP1 ib leeg thiab kev sib xyaw nrog nivolumab hauv cov neeg laus kawm nrog qib siab thiab / lossis refractory cov qog, txhawm rau txiav txim siab ntau tshaj plaws koob tshuaj (MTD) thiab pom zoo rau Theem 2 koob tshuaj (RP2D), nrog rau tshuaj xyuas ua ntej ua tau zoo.
Qhov chaw: 6 thaj chaw
Kawm Hauv Cov Ntsiab Lus Nrog Qhov Chigoidal Melanoma Qib Me
Lub hom phiaj tseem ceeb yog ntsuas qhov kev nyab xeeb, kev tiv thaiv kab mob thiab ua tau zoo ntawm ib qho ntawm peb qib kev noj tshuaj thiab rov ua koob tshuaj rov qab ntawm Lub teeb-qhib AU-011 thiab ib lossis ob daim ntawv thov laser rau kev kho mob ntawm cov ncauj lus nrog choroidal melanoma.
Qhov chaw: 4 thaj chaw
Txoj kev tshawb ntawm IDE196 hauv Cov Neeg Mob Nrog Cov Tum Qog Siv Yooj Yim Harboring GNAQ / 11 Kev Sib Hloov lossis PRKC Fusions
Qhov no yog Ntu 1/2, ntau lub chaw zov me nyuam, qhib lub pob tawb qhib kev kawm tsim los ntsuas qhov kev nyab xeeb thiab tiv thaiv cov qog ua haujlwm ntawm IDE196 hauv cov neeg mob uas muaj cov qog ua hle tawv GNAQ lossis GNA11 (GNAQ / 11) hloov pauv lossis PRKC fusions, suav nrog metastatic uveal melanoma (MUM), mob nqaij hlav melanoma, txiav mob qog nqaij hlav cancer, thiab lwm yam khoom hlav. Ntu 1 (nce mus nce siab) yuav ntsuas txog kev nyab xeeb, kev tiv taus thiab cov chaw muag tshuaj ntawm IDE196 los ntawm cov qauv tshuaj tiv thaiv kab mob thiab txiav txim siab pom zoo Theem 2 koob tshuaj. Kev nyab xeeb thiab kev tawm tsam qog yuav raug tshuaj ntsuam hauv Ntu 2 (nthuav dav ntxiv) ib feem ntawm txoj kev tshawb no.
Qhov chaw: 4 thaj chaw
Selumetinib Sulfate hauv Kev Kho Tus Neeg Mob Nrog Uveal Melanoma lossis GNAQ / GNA11 Mutated Melanoma Uas Yog Metastatic lossis tsis tuaj yeem raug tshem tawm los ntawm Kev Kho Mob
Theem Ib sim no kawm txog cov kev mob tshwm sim thiab qhov zoo tshaj plaws ntawm selumetinib sulfate hauv kev kho cov neeg mob uveal melanoma lossis GNAQ / GNA11 mutated melanoma uas tau kis los ntawm thawj qhov chaw mus rau lwm qhov chaw hauv lub cev lossis tsis tuaj yeem tshem tawm los ntawm kev phais mob. Selumetinib sulfate tuaj yeem nres kev loj hlob ntawm cov qog hlwb los ntawm kev thaiv qee cov enzymes xav tau rau kev loj hlob ntawm tes.
Qhov chaw: 3 thaj chaw
Hloov Kho Tus Kab Mob VSV-IFNbetaTYRP1 hauv Kev Kho Cov Neeg Mob Nrog Theem III-IV Melanoma
Qeb Sim No Kuv sim kawm txog cov kev mob tshwm sim thiab koob tshuaj hloov kab mob hu ua VSV-IFNbetaTYRP1 hauv kev kho mob rau cov neeg mob melanoma theem III-IV. Tus kab mob vesicular stomatitis (VSV) tau hloov kho kom muaj ob hom ntxiv: tib neeg interferon beta (hIFNbeta), uas tuaj yeem tiv thaiv cov hlwb noj qab haus huv los ntawm kev kis tus kab mob, thiab TYRP1, uas yog qhia tshwj xeeb hauv melanocytes (tshwj xeeb cov tawv nqaij ntawm tes uas tsim kev tiv thaiv tawv nqaij-tsaus nti xim melanin) thiab melanoma qog hlwb, thiab yuav ua rau lub zog tiv thaiv kab mob los tua cov mob qog nqaij hlav melanoma.
Qhov chaw: 2 thaj chaw
Qhov Kev Tshawb Nrhiav ntawm PLX2853 hauv Kev Ua Lag Luam Siab.
Lub hom phiaj ntawm cov ntaub ntawv tshawb fawb no yog soj ntsuam kev nyab xeeb, pharmacokinetics, pharmacodynamics thiab kev pib ua kom tau zoo ntawm kev tshawb nrhiav tshuaj PLX2853 hauv cov ncauj lus nrog cov neeg ua haujlwm siab.
Qhov chaw: 2 thaj chaw
Yttrium90, Ipilimumab, & Nivolumab rau Uveal Melanoma Nrog Daim Duab Ua Siab
Cov ntawv tshaj tawm mus txog hnub qhia pom tsawg kawg ntawm kev siv tshuaj tiv thaiv kab mob rau uveal melanoma. Cov kev sim kho thiab cov pov thawj tsis ntev los no qhia pom qhov sib luag ntawm kev siv hluav taws xob thiab kev kho mob. Cov neeg tshawb nrhiav yuav tshawb txog qhov kev lom zem no nrog kev kawm ntawm kev ua tau ntawm 26 cov neeg mob uveal melanoma thiab hepatic metastases leej twg yuav tau txais SirSpheres Yttrium-90 xaiv sab hauv hluav taws xob hepatic taug kev nrog kev kho mob tiv thaiv nrog kev sib xyaw ntawm ipilimumab thiab nivolumab.
Qhov chaw: 2 thaj chaw
Pegargiminase, Nivolumab thiab Ipilimumab hauv Kev Kho Mob Rau Cov Neeg Mob nrog Kev Kawm Tshaj Plaws lossis tsis paub zoo Uveal Melanoma
Lub sijhawm no kuv sim kawm txog kev phiv los ntawm pegargiminase, nivolumab thiab ipilimumab hauv kev kho cov neeg mob uveal melanoma uas tau kis mus rau lwm qhov chaw hauv lub cev (nce siab) lossis tsis tuaj yeem raug tshem tawm los ntawm kev phais mob (tsis tuaj yeem tiv thaiv). Pegargiminase tuaj yeem nres txoj kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes xav tau rau kev loj hlob ntawm tes. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab thiab ipilimumab, tuaj yeem pab lub cev tiv thaiv kab mob tua lub qog ntshav, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau. Muab tshuaj pegargiminase, nivolumab thiab ipilimumab yuav zoo dua yog siv tshuaj tiv thaiv kab mob ib leeg.
Qhov chaw: Memorial Sloan Kettering Cancer Center, New York, New York
Stereotactic Lub Cev Hlaws Hluav Taws Xob Kho Mob thiab Aflibercept hauv Kev Kho Cov Neeg Mob Nrog Uveal Melanoma
Kev sim qib II no kawm txog kev kho lub cev ntawm lub cev ua kom zoo li cas thiab aflibercept ua haujlwm hauv kev kho cov neeg mob uveal melanoma. Stereotactic lub cev hluav taws xob kho siv cov cuab yeej tshwj xeeb los muab tus neeg mob thiab xa cov hluav taws xob rau cov qog hlav nrog qhov ntsuas siab. Txoj kev no tuaj yeem tua cov qog nqaij hlav nrog cov koob tshuaj tsawg dua nyob rau lub sijhawm luv luv thiab ua rau cov ntaub so ntswg tsawg dua. Aflibercept yuav nres kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes xav tau rau kev loj hlob ntawm tes. Kev muab stereotactic lub cev hluav taws xob kho nrog ua raws li aflibercept yuav ua haujlwm zoo dua rau kev kho cov neeg mob uveal melanoma.
Qhov chaw: Thomas Jefferson University Tsev Kho Mob, Philadelphia, Pennsylvania
Qhov Kev Nyab Xeeb thiab Kev Nyab Xeeb ntawm INCAGN02390 hauv Xaiv Advanced Malignancies
Lub hom phiaj ntawm qhov kev kawm no yog txiav txim siab txog kev nyab xeeb, tiv taus, thiab kev ua tau zoo ua ntej ntawm INCAGN02390 hauv cov koom nrog cov xaiv cov neeg ua haujlwm siab.
Qhov chaw: Hackensack University Medical Center, Hackensack, New Jersey
Qhov Tshuaj Tiv Thaiv (6MHP) nrog lossis tsis muaj CDX-1127 rau Kev Kho Mob ntawm theem IIB-IV Melanoma
Kev sim qib I / II qib no yuav kawm txog cov kev mob tshwm sim thiab cov tshuaj tiv thaiv zoo npaum li cas (6MHP) nrog lossis tsis muaj CDX-1127 ua haujlwm rau kev kho theem IIB-IV melanoma. Cov tshuaj tiv thaiv, xws li 6MHP, tuaj yeem pab lub cev tsim kev tiv thaiv zoo los tua cov qog ntshav. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li CDX-1127, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Qhov kev sim siab no tau ua los saib seb muaj dab tsi cuam tshuam rau 6MHP ib leeg thiab muaj kev txuam nrog CDX-1127 muaj rau kev hloov pauv hauv lub cev.
Qhov chaw nyob: University of Virginia Cancer Center, Charlottesville, Virginia
Ipilimumab thiab Nivolumab nrog Immunoembolization hauv Kev Kho Mob Rau Cov Neeg Mob Nrog Metastatic Uveal Melanoma hauv Kev Mob Siab
Kev sim zaum II no tshawb txog ipilimumab thiab nivolumab nrog cov tshuaj tiv thaiv kab mob hauv kev kho cov neeg mob uveal melanoma uas tau kis mus rau lub siab. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li ipilimumab thiab nivolumab, tuaj yeem pab lub cev tiv thaiv kab mob tua cov kab mob qog nqaij hlav, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau. Immunoembolization tuaj yeem tua cov kab mob qog vim tias tsis muaj ntshav txaus thiab tsim kev tiv thaiv kab mob rau cov qog hlwb. Muab cov tshuaj ipilimumab thiab nivolumab nrog cov tshuaj immunoembolization tuaj yeem ua haujlwm zoo dua rau kev kho cov neeg mob uveal melanoma.
Qhov chaw: Thomas Jefferson University Tsev Kho Mob, Philadelphia, Pennsylvania
Cyclophosphamide, Fludarabine, Tumor Infiltrating Lymphocytes, thiab Aldesleukin hauv Kev Kho Cov Neeg Koom nrog Metastatic Uveal Melanoma
Kev sim qib II no paub txog mob cyclophosphamide, fludarabine, cov qog ua mob lymphocytes, thiab aldesleukin ua haujlwm rau kev kho cov neeg koom nrog uveal melanoma uas tau kis mus rau lwm qhov chaw hauv lub cev. Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li cyclophosphamide thiab fludarabine, ua haujlwm nyob rau hauv txoj hauv kev sib txawv los tiv thaiv kev loj hlob ntawm cov qog nqaij hlav, los ntawm tua cov qog hlwb, los ntawm kev txwv kom tsis txhob faib tawm, lossis txwv tsis pub kis mus rau lwm qhov. Cov nqaij hlav mob ua rau mob nqaij hlav ua paug rau cov nqaij hlav ua paug. Aldesleukin yuav txhawb cov qe ntshav dawb kom tua cov uveal melanoma. Kev muab cov tshuaj cyclophosphamide, fludarabine, cov qog ua mob lymphocytes, thiab aldesleukin tuaj yeem tua cov qog ua qog ntau dua.
Qhov Chaw: University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
Autologous CD8 + SLC45A2-Tshwj xeeb T Lymphocytes nrog Cyclophosphamide, Aldesleukin, thiab Ipilimumab hauv Kev Kho Cov Neeg Koom nrog Metastatic Uveal Melanoma
Theem Ib ntu kev kawm txog cov kev mob tshwm sim thiab cov koob tshuaj zoo tshaj plaws ntawm autologous CD8 zoo (+) SLC45A2 kev qhia tshwj xeeb T lymphocytes thaum muab ua ke nrog cyclophosphamide, aldesleukin, thiab ipilimumab, thiab kom pom tias lawv ua haujlwm zoo npaum li cas rau kev kho cov neeg koom nrog uveal melanoma uas tau sib kis. mus rau lwm qhov chaw hauv lub cev. Txhawm rau ua cov hlwb tshwj xeeb CD8 + T, cov kws tshawb nrhiav cais tawm T cov ntawv sau los ntawm cov ntshav koom thiab kho lawv kom lawv tuaj yeem tsom tau cov hlwb melanoma. Cov ntshav tom qab ntawd muab rov qab rau tus neeg koom nrog. Qhov no hu ua "saws me nyuam hloov pauv T cell" lossis "saws T T kev kho mob ntawm tes." Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li cyclophosphamide, tuaj yeem ua haujlwm nyob rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog nqaij hlav, los ntawm kev tua cov qog, los ntawm kev txwv kom tsis txhob faib tawm, lossis txwv tsis pub kis mus rau lwm qhov. Kho kev siv roj ntsha, xws li aldesleukin, siv cov tshuaj uas tsim los ntawm cov kab mob muaj sia uas tuaj yeem ua kom muaj zog tiv thaiv kab mob hauv lub cev sib txawv thiab txwv tsis pub cov qog ua kom loj hlob. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li ipilimumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Muab cov tshuaj lom neeg CD8 + SLC45A2 tshwj xeeb T lymphocytes ua ke nrog cyclophosphamide, aldesleukin, thiab ipilimumab tuaj yeem ua haujlwm zoo dua rau kev kho cov neeg koom nrog metastatic uveal melanoma.
Qhov Chaw: MD Anderson Cancer Center, Houston, Texas
Intravenous thiab Intrathecal Nivolumab hauv Kev Kho Mob Rau Cov Neeg Mob Uas Mob Leptomeningeal
Theem I / Ib sim kev kawm txog qhov tshwm sim thiab qhov zoo tshaj plaws ntawm intrathecal nivolumab, thiab nws ua haujlwm zoo npaum li cas ua ke nrog kev txhaj tshuaj nivolumab hauv kev kho mob rau cov neeg mob leptomeningeal. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau.
Qhov Chaw: MD Anderson Cancer Center, Houston, Texas
Nivolumab nrog lossis tsis muaj Ipilimumab lossis Relatlimab ua ntej Kev phais mob hauv Kev Kho Mob rau Cov Neeg Mob Theem IIIB-IV Melanoma Uas Tuaj yeem tshem tawm los ntawm Kev phais
Qhov kev sim rau qib II no sim tshawb xyuas seb nivolumab zoo li cas lossis tsis muaj ipilimumab lossis relatlimab ua ntej kev kho mob ua haujlwm rau kev kho mob rau cov neeg mob theem IIIB-IV melanoma uas tuaj yeem tshem tawm los ntawm kev phais mob. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab, ipilimumab, thiab relatlimab, tuaj yeem pab lub cev tiv thaiv kab mob tua cov qog mob cancer, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav hlav kom loj hlob thiab kis tau. Kev muab nivolumab ib leeg lossis ua ke nrog ipilimumab lossis relatlimab ua ntej kev phais mob yuav ua rau cov qog ntshav me thiab txo qhov nqaij mos uas yuav tsum tau muab tshem tawm.
Qhov Chaw: MD Anderson Cancer Center, Houston, Texas
6MHP Tshuaj Tiv Thaiv thiab Ipilimumab hauv Kev Kho Mob rau Cov Neeg Mob Ntu IIA-IV Melanoma
Theem I / II kev sim no kawm txog kev phiv tshuaj 6 melanoma tus pab tiv thaiv peptide (6MHP) thiab ipilimumab thiab kom pom tias lawv ua haujlwm zoo npaum li cas rau kev kho mob rau cov neeg mob melanoma theem-IV. Cov tshuaj tiv thaiv uas ua los ntawm peptides, xws li 6MHP txhaj tshuaj, tuaj yeem pab lub cev tsim cov kev tiv thaiv zoo los tua cov qog ntshav. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li ipilimumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau. Tseem tsis tau paub meej tias kev muab tshuaj 6MHP thiab ipilimumab ua haujlwm zoo dua rau kev kho tus neeg mob melanoma.
Qhov chaw nyob: University of Virginia Cancer Center, Charlottesville, Virginia
Dabrafenib Mesylate, Trametinib, thiab 6 Melanoma Tus Pab Peptide Cov Tshuaj Tiv Thaiv hauv Kev Kho Cov Neeg Mob Theem IIIB-IV Melanoma
Qhov kev sim rau qib I / II no kawm txog cov kev mob tshwm sim thiab zoo li casrafenib mesylate, trametinib, thiab 6 melanoma tus pab peptide cov tshuaj tiv thaiv ua haujlwm hauv kev kho cov neeg mob theem IIIB-IV melanoma. Dabrafenib mesylate thiab trametinib tuaj yeem nres kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes uas xav tau rau kev loj hlob ntawm tes. Cov tshuaj tiv thaiv, xws li 6 melanoma tus pab peptide tshuaj tiv thaiv, ua los ntawm peptides muab los ntawm melanoma cov nqaijrog, tuaj yeem pab lub cev tsim cov kev tiv thaiv zoo los tua cov qog hlwb uas qhia cov tshuaj melanoma-antigens. Muab cov dabrafenib, trametinib, thiab 6 melanoma tus pab peptide tshuaj tiv thaiv kab mob tuaj yeem ua haujlwm zoo dua rau kev kho cov neeg mob melanoma.
Qhov chaw nyob: University of Virginia Cancer Center, Charlottesville, Virginia
Sunitinib Malate lossis Valproic Acid rau kev tiv thaiv Metastasis hauv cov neeg mob Nrog Kev phom sij Uveal Melanoma
Qhov kev sim rau qib II no sim tshawb xyuas seb cov hnub ua haujlwm sunitinib malate lossis valproic acid ua haujlwm zoo li cas hauv kev tiv thaiv kev pheej hmoo ua mob ntsej muag (qhov muag) melanoma tsis txhob kis mus rau lwm qhov ntawm lub cev. Sunitinib malate tuaj yeem nres kis ntawm cov cim qhia kev loj hlob mus rau cov qog hlwb thiab tiv thaiv cov hlwb no tsis tuaj yeem loj hlob. Valproic acid tuaj yeem hloov qhov kev qhia ntawm qee cov caj ces hauv uveal melanoma thiab txhawb kev hlav loj.
Qhov chaw: Thomas Jefferson University Tsev Kho Mob, Philadelphia, Pennsylvania
Tumor Infiltrating Lymphocytes thiab Cov Koob Tshuaj Ntshav Aldesleukin nrog lossis tsis muaj Autologous Dendritic Cells hauv kev kho cov neeg mob nrog Metastatic Melanoma
Qhov kev sim kho nyob rau qib II no kawm txog kev kho cov qog ntshav ua rau cov kab mob lymphocytes zoo li cas thiab cov tshuaj aldesleukin ntau npaum li cas nrog lossis tsis muaj cov kabmob ua rau lub hlwb ua haujlwm rau kev kho cov neeg mob melanoma uas tau kis mus rau lwm thaj chaw ntawm lub cev. Cov tshuaj tiv thaiv ua los ntawm ib tug neeg lub qog hlwb thiab cov qe ntshav tshwj xeeb (dendritic cells) yuav pab lub cev tsim cov kev tiv thaiv zoo los tua cov qog ntshav. Aldesleukin tuaj yeem txhawb cov qe ntshav dawb kom tua cov qog ntshav. Nws tseem tsis tau paub meej tias kev kho cov qog ua rau cov ntshav lymphocytes thiab cov tshuaj aldesleukin ntau dua li cov tshuaj tau zoo dua thaum muab ua ke nrog lossis tsis muaj hlwb dendritic hauv kev txo qis lossis qeeb ntawm kev loj hlob ntawm melanoma. Cov txiaj ntsig kho tau ntawm kev tau txais cov qog ua mob lymphocytes (TIL) ua ke nrog B-Raf proto-oncogene, Yuav kawm txog cov kab mob serine / threonine kinase (BRAF) inhibitor, hauv cov neeg mob uas muaj kabmob (PD) nrog kev siv BRAF inhibitor ua ntej kev kho mob TIL. Tus mob Leptomeningeal (LMD) yog hmoov tsis zoo uas tshwm sim rau cov neeg mob melanoma, uas muaj qhov tsis txaus ntseeg, txhais tau tias kev ciaj sia tag nrho tsuas yog nyob rau ob asthiv xwb. Nrog txoj kev tshiab los ntawm kev sib xyaw ntawm cov TIL thiab intrathecal interleukin (IL) -2, cov neeg tshawb nrhiav vam tias yuav ua kom muaj kab mob nyob ntev lossis hloov kho ntawm LMD.
Qhov Chaw: MD Anderson Cancer Center, Houston, Texas
Vorinostat rau Kev Kho Mob Ntawm Chav Kawm 2 Ib Qho Kev pheej hmoo Uveal Melanoma
Kev sim ua ntu zus thaum ntxov no Kuv sim tshawb xyuas seb vorinostat ua haujlwm zoo li cas rau kev kho cov neeg mob uas muaj kev pheej hmoo siab uveal (qhov muag) melanoma. Cov kws tshawb nrhiav pom tias cov cell hauv uveal melanomas feem ntau muab faib ua ob hom: chav kawm 1 thiab chav kawm 2. Cov chav kawm 2 lub hlwb muaj feem ntau yuav muaj feem ntau dua mus rau lwm qhov hauv lub cev, thaum chav 1 feem ntau nyob hauv qhov muag. Vorinostat tuaj yeem hloov chav kawm 2 lub hlwb mus rau hauv chav kawm tsawg dua 1-hom hlwb los ntawm "tig mus" rau cov noob hauv lub xovtooj uas txhawb kev hlav.
Qhov Chaw: Tsev Kawm Ntawv ntawm Miami Miller Lub Tsev Kawm Ntawv ntawm Tshuaj-Sylvester Cancer Center, Miami, Florida
Ulixertinib hauv Kev Kho Cov Neeg Mob Nrog Theem IV Uveal Melanoma
Kev sim qib II no kawm txog kev mob tshwm sim ntawm ulixertinib thiab nws ua haujlwm zoo npaum li cas rau kev kho mob rau cov neeg mob IV uveal melanoma. Ulixertinib yuav tso tseg txoj kev loj hlob ntawm qog nqaij hlav los ntawm kev thaiv qee cov enzymes uas xav tau rau kev loj hlob ntawm tes.
Qhov Chaw Nyob: Saib Clinical Trials.gov
Vorinostat hauv Kev Kho Cov Neeg Mob Nrog Metastatic Melanoma ntawm Qhov Muag
Kev sim qib II no tshawb xyuas seb vorinostat ua haujlwm zoo li cas hauv kev kho cov neeg mob melanoma ntawm lub qhov muag uas tau kis mus rau lwm qhov ntawm lub cev. Vorinostat tuaj yeem tso tseg txoj kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes xav tau rau kev loj hlob ntawm tes.
Qhov Chaw Nyob: Saib Clinical Trials.gov
