Txog-mob cancer / kho mob / kuaj mob-kuaj mob / mob / extragonadal-kab-ntawm tes-qog / kho

Kev Kho Tej Chaw Kuaj Mob rau Cov Qog Pob Tawb Extragonadal Germ Cell

Cov chaw kuaj mob yog cov kev tshawb fawb tshawb fawb uas cuam tshuam nrog tib neeg. Kev soj ntsuam kab mob hauv cov npe no yog rau kev kho kab mob cell pob kws kho pob qij txha. Txhua qhov kev sim ntawm daim npe tau txhawb los ntawm NCI.

NCI cov ncauj lus tseem ceeb txog kev sim kho mob piav qhia txog ntau hom thiab ncua sij hawm ntawm kev sim thiab seb lawv raug coj los ua li cas. Cov chaw soj ntsuam kuaj xyuas txoj hauv kev tshiab los tiv thaiv, kuaj pom, lossis kho kab mob. Tej zaum koj yuav xav xav txog kev koom tes hauv kev sim tshuaj kuaj mob. Tham nrog koj tus kws kho mob kom pab txiav txim siab yog tias ib qho zoo rau koj.

Kev Hais Plaub 1-7 ntawm 7

Kev soj ntsuam nquag, Bleomycin, Carboplatin, Etoposide, lossis Cisplatin hauv kev kho mob rau menyuam yaus thiab cov neeg laus uas mob qog nqaij hlav Cell

Kev sim qib III no kawm txog kev soj ntsuam zoo npaum li cas, bleomycin, carboplatin, etoposide, lossis cisplatin ua haujlwm hauv kev kho cov menyuam yaus thiab cov neeg laus muaj mob qog nqaij hlav. Kev soj ntsuam nquag yuav pab cov kws kho mob saib xyuas cov ncauj lus uas muaj cov qog ua qog qis qis tom qab lawv cov qog tawm. Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li bleomycin, carboplatin, etoposide, thiab cisplatin ua haujlwm rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog hlwb, los ntawm tua cov hlwb, los ntawm kev txwv kom tsis txhob faib tawm, los yog txwv tsis pub kis.

Qhov chaw: 435 thaj chaw

Kev nrawm lossis qauv BEP Kev Siv Tshuaj Kho Mob hauv Kev Kho Mob Cov Neeg Mob Nruab Nrab lossis Qis Tsis Zoo Kev Raug Ploj Kab Ntsig

Qhov kev sim rau qib III no kawm txog seb lub sijhawm teev ntshav sai sai npaum li cas ntawm bleomycin sulfate, etoposide phosphate, thiab cisplatin (BEP) kws kho mob ua haujlwm piv rau cov sijhawm ua haujlwm ntawm BEP kev kho tshuaj hauv kev kho cov neeg mob nruab nrab lossis qis qis cov kabmob qog uas tau kis mus rau lwm yam cov chaw hauv lub cev (metastatic). Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li bleomycin sulfate, etoposide phosphate, thiab cisplatin ua haujlwm rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog hlwb, los ntawm kev tua cov qog, los ntawm kev txwv kom tsis txhob faib tawm, los yog txwv tsis pub kis. Kev muab tshuaj BEP ua rau tshuaj lom neeg mob sai dua, lossis "ua kom ceev nrawm dua" tuaj yeem ua haujlwm zoo dua nrog cov kev mob tshwm sim tsawg dua hauv kev kho mob rau cov neeg mob cov neeg mob qog nruab nrab lossis tsis muaj kabmob txaus rau cov kabmob qog nqaij hlav ua piv rau cov qauv sijhawm.

Qhov chaw: 126 qhov chaw

Txheem-Koob Tshaj Tawm Kev Kho Mob Siv Tshuaj lossis Kuaj Mob Tshaj Tawm Nrog Kev Kho Mob thiab Qia Hlawv Hloov Hauv Kev Kho Mob Rau Cov Neeg Mob Nrog Rov Kho Mob Los

Qhov kev sim rau qib III sim no pom tau tias kev siv tshuaj sib xyaw ua ke zoo npaum li cas piv rau kev siv tshuaj sib xyaw ua ke thiab kev hloov cov qog ntshav hauv kev kho cov neeg mob qog mob qog uas tau rov qab los tom qab kev txhim kho lossis tsis teb rau kev kho. Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li paclitaxel, ifosfamide, cisplatin, carboplatin, thiab etoposide, ua haujlwm rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog hlwb, los ntawm tua cov hlwb, los ntawm kev txwv kom tsis txhob faib tawm, lossis los ntawm txwv tsis pub kis. Muab cov tshuaj kho ua ntej lub qog cell hloov tso tseg txoj kev loj hlob ntawm cov qog nqaij hlav cancer los ntawm kev txwv tsis pub faib lossis faib lawv. Tso cov tshuaj colony-stimulating lwm yam, xws li filgrastim lossis pegfilgrastim, thiab qee yam tshuaj kho mob, pab cov qia hlwb txav los ntawm cov pob txha pob txha mus rau cov ntshav kom lawv tuaj yeem sau thiab khaws cia. Kev siv tshuaj kho cov tshuaj yog tom qab txhawm rau npaj cov pob txha pob txha rau lub qog cell hloov ntshav. Tom qab ua cov qia hlwb rov qab rau tus neeg mob mus hloov cov ntshav tsim uas raug rhuav tshem los ntawm kev siv tshuaj kho mob. Tseem tsis tau paub meej tias kev siv tshuaj ntau dua los ntawm kev siv tshuaj kho lub cev thiab kev hloov cov qog ua kom zoo tshaj li kev siv tshuaj sib ntxiv rau txoj kev kho mob hauv kev kho cov neeg mob uas muaj cov kabmob loj lossis rov mob loj hauv lub cev.

Qhov chaw: 54 thaj chaw

Durvalumab thiab Tremelimumab hauv Kev Kho Mob Rau Cov Neeg Mob Nrog Rov Mob lossis Refractory Germ Cell Tumors

Kev sim qib II no tshawb xyuas seb durvalumab thiab tremelimumab ua hauj lwm zoo rau kev kho cov neeg mob qog ntawm cov qog uas tau rov qab los tom qab ib lub sijhawm txhim kho lossis tsis teb rau kev kho mob. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li durvalumab thiab tremelimumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kab mob cancer, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau.

Qhov chaw: 7 thaj chaw

Autologous Peripheral Ntshav Qog Cell Hloov Mus Rau Ntshav Cell Cell

Cov kev kho rau cov neeg mob rov huam tuaj los yog rov huam dua (GCT) cov neeg mob tsawg. Kev siv tshuaj kho mob siab nrog rau kev tiv thaiv qia ntawm tes (qog lub hlwb ntawm lub cev hloov pauv hloov), thaum muab cov tshuaj txuas mus ntxiv, tau qhia tias ib ntu ntawm cov neeg mob tuaj yeem kho tau. Qhov zoo tshaj plaws txoj kev noj tshuaj siab zoo ntxiv rau kev noj tshuaj, txawm li cas los xij, tsis paub txog. Hauv qhov kev sim no, peb yuav siv tandem autologous transplants nrog cov khoom siv hluav taws xob tsis muaj kev tiv thaiv kom zoo los kho cov neeg mob uas rov huam mob / tso tawm GCTs.

Qhov Chaw: University of Minnesota / Masonic Cancer Center, Minneapolis, Minnesota

Melphalan, Carboplatin, Mannitol, thiab Sodium Thiosulfate hauv Kev Kho Mob rau Cov Neeg Mob uas Muaj Mob Rov Qab Los Loj Dua lossis Zwm Zes

Theem I / II kev sim no kawm txog cov kev mob tshwm sim thiab qhov zoo tshaj plaws ntawm melphalan thaum muab ua ke nrog carboplatin, mannitol, thiab sodium thiosulfate, thiab kom pom tias lawv ua haujlwm zoo npaum li cas rau kev kho cov neeg mob rov qab los yog ua lub siab loj ntawm lub paj hlwb (CNS) embryonal lossis kab mob hlav hlav. Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li melphalan thiab carboplatin ua haujlwm nyob rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog nqaij hlav, los ntawm tua cov qog hlwb, los ntawm kev txwv lawv kom faib, lossis txwv tsis pub kis mus rau lwm qhov. Osmotic ntshav-hlwb cuam tshuam kev cuam tshuam (BBBD) siv mannitol los qhib cov hlab ntshav nyob ib ncig ntawm lub hlwb thiab cia cov tshuaj tua kabmob kheesxaws nqa ncaj qha mus rau lub hlwb. Sodium thiosulfate tuaj yeem pab txo qis lossis tiv thaiv qhov tsis hnov ​​lus thiab muaj tshuaj lom rau hauv cov neeg mob uas siv tshuaj kho mob nrog carboplatin thiab BBBD.

Qhov chaw: 2 thaj chaw

Cov Tshuaj Ntsaws Cov Ntsej Muag Lysate Cov Tshuaj Tiv Thaiv thiab Iscomatrix Nrog lossis Tsis Muaj Metronomic Oral Cyclophosphamide thiab Celecoxib hauv Cov Neeg Mob Nrog Malignancies Kev Nqaij Ntshav, Mob Nqa, Pleophagus, Pleura, lossis Mediastinum

Keeb Kwm: Xyoo tas los, kab mob cancer-testis (CT) antigens (CTA), tshwj xeeb yog cov cim ntawm cov noob ntawm X chromosome (CT-X noob), tau tawm los ua cov hom phiaj zoo nkauj rau kev kho mob cancer. Whereas malignancies ntawm ntau haiv histologies qhia ntau yam ntawm CTAs, cov lus teb tiv thaiv kab mob rau cov protein tsis pom qhov tsis tshua muaj tshwm sim hauv cov neeg mob qog nqaij hlav, tejzaum nws vim muaj cov theem qis, heterogeneous antigen qhia, ntxiv rau immunosuppressive ntxawg T cell tuaj hauv cov kabmob thiab cov kab mob ntawm cov neeg no Cov. Qhov tsis yooj yim, kev txhaj tshuaj tiv thaiv cov neeg mob qog noj ntshav nrog cov qog nqaij hlav tawm hais txog qib siab ntawm CTAs ua ke nrog cov kev tswj hwm uas ua tsis tiav lossis inhibit T kev tswj hlwb yuav ua rau muaj kev tiv thaiv dav rau cov antigens. Txhawm rau tshuaj xyuas qhov teeb meem no, cov neeg mob uas ua rau qog mob ntsws thiab txoj hlab nqos mov, pleural mesotheliomas, thoracic sarcomas, thymic neoplasms thiab mediastinal kab mob ntawm cov qog hlav, nrog rau sarcomas, melanomas, qog cov qog, lossis mob ua paug rau cov ntsws, pleura lossis mediastinum tsis muaj pov thawj ntawm tus kab mob (NED) los yog cov kab mob tsis tshua muaj kab mob (MRD) ua raws cov qauv kev kho mob ntau txhaj tshuaj tiv thaiv kab mob nrog H1299 cov qog cell lysates nrog Iscomatrix adjuvant. Cov tshuaj tiv thaiv yuav raug txhaj nrog lossis tsis muaj qhov sib luag ntawm lub qhov ncauj cyclophosphamide (50 mg PO BID x 7d q 14d), thiab celecoxib (400 mg PO BID). Serologic cov lus teb rau ntau cov lus teb rov qab rau CTAs zoo li cov tshuaj tiv thaiv kab mob rau cov qog ua ntshav lossis tshuaj kho mob rau cov leeg yuav tsum tau ntsuas ua ntej thiab tom qab rau lub sijhawm txhaj rau lub hlis. Lub Hom Phiaj Tseem Ceeb: 1. Txheeb xyuas cov zaus ntawm cov tshuaj tiv thaiv kab mob rau CTAs hauv cov neeg mob thoracic malignancies tom qab txhaj tshuaj nrog H1299 cell lysate / Iscomatrix (TM) cov tshuaj tiv thaiv ib leeg piv rau cov neeg mob thoracic malignancies tom qab txhaj tshuaj tiv thaiv nrog H1299 cell lysate / Iscomatrix tshuaj tiv thaiv ua ke nrog kev tiv thaiv kab mob metronomic cyclophosphamide thiab celecoxib Cov. Lub Hom Phiaj Thib Ob: 1. Tshawb xyuas yog tias qhov ncauj ua rau lub cev cyclophosphamide thiab kev kho mob celecoxib txo qis tus naj npawb thiab feem pua ​​ntawm T kev tswj hlwb thiab ploj zuj zus kev ua haujlwm ntawm cov hlwb no hauv cov neeg mob thoracic malignancies muaj qhov pheej hmoo rov ua dua. 2. Txheeb xyuas yog tias H1299 ntawm tes lysate / Iscomatrix (TM) kev txhaj tshuaj tiv thaiv ua rau muaj kev tiv thaiv kab mob rau cov qog ua ntshav lossis epigenetically hloov kho autologous EBV-hloov lymphocytes (B hlwb). Kev Tsim Nyog Tau: - Cov neeg mob uas muaj keeb kwm pov thawj lossis cytologically ua pov thawj me me los sis mob qog nqaij hlav hauv hlwb tsis yog mob ntsws me me (SCLC; NSCLC), mob qog nqaij hlav esophageal (EsC), malignant pleural mesothelioma (MPM), mob thymic lossis mediastinal cell hlav qog, thoracic sarcomas, lossis melanomas, sarcomas, lossis epithelial malignancies metastatic mus rau lub ntsws, pleura lossis mediastinum uas tsis muaj pov thawj hauv kev muaj tus kabmob (NED), lossis cov kabmob tsis tshua muaj siab (MRD) tsis nkag tau los ntawm kev tsis muaj qhov txhab lossis rov kis dua / hluav taws xob raws li cov txheej txheem kho tau ua tiav tsis dhau 26 lub lis piam dhau los Cov. - Cov neeg mob yuav tsum yog 18 xyoo lossis tshaj saud nrog rau ECOG kev ua tau zoo ntawm 0 2. - Cov neeg mob yuav tsum muaj tus mob pob txha txaus, raum, mob siab, mob ntsws thiab mob plawv. - Cov neeg mob yuav tsis nyob rau cov tshuaj tiv thaiv kab mob kev tiv thaiv thaum lub sij hawm pib txhaj tshuaj. Tsim: - Tom qab rov zoo los ntawm kev phais, kev siv tshuaj kho mob, lossis chemo / XRT, cov neeg mob NED lossis MRD yuav txhaj tshuaj tiv thaiv los ntawm IM txhaj nrog H1299 cell lysates thiab Iscomatrix (TM) tsis tu ncua ib hlis rau 6 lub hlis. - Cov tshuaj tiv thaiv yuav raug txhaj nrog lossis tsis muaj metronomic qhov ncauj cyclophosphamide thiab celecoxib. - Cov tshuaj tiv thaiv tsis huv rau lub cev thiab cov tshuaj tiv thaiv kab mob rau kev kho yuav raug sau tseg. Ua ntej thiab tom qab txhaj tshuaj serologic thiab xov tooj ntawm tes kho kom zoo rau cov lus teb ntawm tus txheej txheem ntawm CT antigens zoo li cov leeg mob hlwb (yog tias muaj) thiab EBV-hloov lymphocytes yuav raug tshuaj ntsuas ua ntej thiab tom qab txhaj tshuaj. - Cov naj npawb / feem pua ​​thiab kev ua haujlwm ntawm T ntxawg hlwb hauv cov ntshav nruab nrab yuav raug ntsuas ua ntej, thaum, thiab tom qab txhaj tshuaj. - Cov neeg mob yuav raug soj qab hauv tsev kho mob nrog cov kab mob kev soj ntsuam kom txog thaum rov ua kom rov muaj kab mob.

Qhov Chaw: Cov Tsev Kawm Ntawv Hauv Tebchaws ntawm Chaw Kuaj Mob Noj Qab Haus Huv, Bethesda, Maryland