ʻImi / wahi / hoʻokolohua hoʻokolohua / nctn
Nā ʻikepili i loko
- 1 NCTN: Pūnaewele Hoʻokolohua Lapaʻau National NCI
- 1.1 Nā Pūʻulu Pūnaewele a me kā lākou mau mea kākoʻo
- 1.2 Nā Papa Kālā ʻAoʻao Kālā Hoʻokele (LAPS)
- 1.3 Nā Halemai Kaiāulu a me nā Hale Lapaʻau
- 1.4 Pūʻulu Kuhi Oncology Imaging a me Radiation (IROC)
- 1.5 Nā Makana ʻEpekema Unuhi Unuhi (ITSA)
- 1.6 Nā Panakō Nūhou NCTN
- 1.7 Nā Kōmike Hoʻokele ʻepekema
- 1.8 NCTN Palapala Waihona
- 1.9 Nā hana i ka laulima ʻana
- 1.10 Kākoʻo hou
NCTN: Pūnaewele Hoʻokolohua Lapaʻau National NCI
ʻO ka NCI National Clinical Trials Network (NCTN) kahi hōʻuluʻulu o nā hui a me nā kauka e hoʻohui a kākoʻo i nā hoʻokolohua hoʻokolohua maʻi maʻi maʻi ma mua o nā pūnaewele 2,200 a puni ka United States, Canada, a me ka honua. Hāʻawi ʻo NCTN i nā ʻōnaehana no ka mālama ʻana i kākoʻo kālā ʻia e NCI a me nā hoʻokolohua kiʻi mua mua e hoʻomaikaʻi i ke ola o ka poʻe me ka maʻi ʻaʻai.
Kōkua nā hoʻokolohua hoʻokolohua NCTN e hoʻokumu i nā kūlana hou o ka mālama, hoʻonohonoho i ke kahua no ka ʻae ʻia o nā therapies hou e ka Food and Drug Administration, e hoʻāʻo i nā hana lapaʻau hou, a hōʻoia i nā biomarkers hou.
Ua hoʻokumu ʻo NCI i kekahi mau hoʻokolohua ma o ka NCTN, me:
- ALCHEMIST: ʻO ka Adjuvant Lung Cancer Enrichment Marker Identification a me nā hoʻāʻo ʻana i ke kau ʻana
- DART: Pālua Anti-CTLA-4 a me Anti-PD-1 Blockade i ka Rare Tumors Trial
- Lung-MAP: Phase II / III Biomarker-Driven Master Protocol no ka Laina Lapaʻau no nā pae holomua o nā puʻuwai liʻiliʻi liʻiliʻi loa.
- NCI-MATCH: Nānā Molecular no Choice Therapy no nā mākua me nā maʻi ʻaʻai holomua
- NCI-COG Pediatric MATCH: Molecular Analysis for Therapy Choice no nā keiki a me nā ʻōpio makua me nā maʻi kōkō holomua
- NCI-NRG ALK Master Protocol: ʻO kahi hoʻokolokolo i hoʻokele ʻia e ka biomarker no nā mea maʻi NSCLC non-squamous ALK i mālama mua ʻia.
Nā Pūʻulu Pūnaewele a me kā lākou mau mea kākoʻo
Kūpono ka ʻōnaehana hoʻonohonoho o ka pūnaewele no ka kānana ʻana i nā helu he nui o nā mea maʻi e ʻike i ka poʻe nona nā tumors e hōʻike ana i nā hiʻohiʻona molekiola e hāʻawi iā lākou i ka manawa kūpono maikaʻi loa e pane i nā lāʻau lapaʻau hou. No nā kauka a me ko lākou poʻe maʻi, loaʻa ākea ka papa kuhikuhi o nā hoʻokolohua koʻikoʻi ma ka ʻāina holoʻokoʻa, ma nā kūlanakauhale nui a me nā kaiāulu liʻiliʻi. Hāʻawi ʻo NCTN i ke komo ʻana i nā ala maikaʻi loa i loaʻa no nā maʻi maʻamau he nui a maʻamau, a ʻoi loa hoʻi.
ʻO ka nānā ʻana o ka NCTN — kāna hoʻonohonoho hoʻonohonoho, ke kālā kālā, a me ke kuhikuhi lōʻihi lōʻihi - aia ia ma lalo o ka mana o ke Kōmike Aʻoaʻo Hoʻohālikelike ʻImi ʻImi (CTAC). Hoʻokomo ʻia kēia kōmike aʻoaʻo aʻoaʻo pekelala i nā loea hoʻokolohua hoʻokolohua, nā ʻelele ʻoihana, a me nā mea kōkua maʻi mai nā ʻāina āpau a hāʻawi i nā ʻōlelo aʻoaʻo i ka luna NCI.
Pūʻulu Pūnaewele
Aia nā NCTN ʻehā mau pūʻulu mākua a hoʻokahi hui nui e kau wale ana i nā maʻi ʻōpio. Hoʻokomo pū ʻia ka hanana i kahi ʻoihana ʻoihana ʻo Kanada e laulima ana i nā hōʻailona hoʻokolohua. ʻO nā Pūʻulu Pūnaewele ʻelima ʻo US:
- Alliance no nā hoʻokolohua hoʻokolohua ma OncologyExit Disclaimer
- Pūʻulu ʻImi ʻImi ECOG-ACRIN E haʻalele i ka hōʻole
- NRG OncologyExit Hoʻolaha
- Hoʻolaha SWOGExit
- Pūʻulu Oncology Pūʻulu (COG) Hoʻolaha Kūpono
Hāʻawi kālā ʻia nā hui US ma o nā makana ʻokoʻa ʻelua - hoʻokahi e kākoʻo i nā lawelawe Pūnaewele a ʻo kekahi e kākoʻo i nā Helu Heluhelu a me nā Pūnaewele ʻIkepili. ʻO nā keʻena hana ke kuleana no ka hoʻomohala ʻana i nā kuʻina hana hou a me ka mālama ʻana i nā kōmike hoʻonohonoho, kālā, lālā a me nā ʻepekema o kēlā me kēia hui. ʻO nā keʻena helu helu ke kuleana no ka mālama ʻana i ka ʻikepili a me ka hōʻiliʻili ʻana, ka hoʻomākaukau ʻana i ka palapala, a me ka mālama ʻana i ka palekana, me ke kōkua ʻana i ka hoʻolālā hoʻokolokolo a me ka hoʻomohala ʻana.
ʻO nā hui ʻoihana Pūnaewele ʻo Kanada me nā Pūnaewele Pūnaewele US ma ke ʻano o ke koho ʻana, ka hopena o ka manawa, nā hoʻokolohua hoʻokolohua pūnaewele lehulehu. ʻO ka Pūnaewele Pūnaewele ʻo Kanada ʻo:
- ʻO ka hui hōʻaia ʻo Kanesa Kanaka (CCTG) Hoʻolaha Kūpono
Hoʻokaʻawale nā hana pūnaewele a me nā kikowaena helu no kēlā me kēia hui NCTN akā hana like pū. Aia lākou ma ke kula ʻoihana i hāʻawi ʻia e "hale" i ka hui; Eia nō naʻe, i nā manawa he nui, aia ke kikowaena ma kahi pūnaewele kūʻokoʻa i kālā kālā ʻia ma o kahi kumu nonprofit. ʻO ka mea ʻokoʻa wale nō i luna aʻe nei ʻo ka Kanada Collaborating Clinical Trials Network, i loaʻa i hoʻokahi makana no kāna Operations a me Statistics.
Nā Papa Kālā ʻAoʻao Kālā Hoʻokele (LAPS)
Ua hāʻawi ʻia he kanakolukūmālua mau kula ʻāpana US i kahi haʻawina Lead Academic komo i ka Pūnaewele (LAPS), kahi kumu o ke kālā i hana nui ʻia no ka NCTN. ʻO nā pūnaewele nā hale noiʻi noiʻi me nā papahana hoʻomaʻamaʻa pilina, a ʻo ka hapa nui o nā mea i hāʻawi ʻia he NCI-Designated Cancer Centres. No ka loaʻa ʻana o kēia mau makana, pono i nā pūnaewele e hōʻike i ko lākou hiki ke kākau inoa i nā helu kiʻekiʻe o nā mea maʻi ma nā hoʻokolohua NCTN, a me ke alakaʻi ʻepekema i ka hoʻolālā a me ka hoʻokele o nā hoʻokolohua hoʻokolohua.
ʻO nā mea kōkua he 32 LAPS:
Ke Kulanui Reserve ʻo Case Western - Hōʻuluʻulu maʻi maʻi maʻi maʻi ʻo Dana Farber / Harvard Cancer Center
Ke Keʻena ʻInikena Kanaka Duke ma ke Kulanui Lapaʻau ʻo Ke Kula Nui ʻo Duke
Kulanui Emory - Winship Cancer Institute
ʻO Fred Hutchinson Cancer Research Center
Ke Kulanui ʻo Johns Hopkins - Ke Kulanui Kanikau ʻO Sidney Kimmel
Hale Kukino maʻi maʻi ʻo Mayo
Kulanui Lapaʻau o Wisconsin
Kahi hoʻomanaʻo Cancer Sloan Kettering Cancer Center
ʻO Norris Cotton Cancer Center ma Dartmouth Hitchcock Medical Center
Ke Kulanui o Northwestern - ʻO Robert H. Lurie Comprehensive Cancer Center
Ke Kulanui Kanikau Kūpono ʻo Ohio State University
ʻO Roswell Park Cancer Institute
ʻO Sidney Kimmel Cancer Center ma Jefferson Health
Kulanui o Alabama ma Birmingham
Kulanui o Kaleponi ʻO Davis Comprehensive Cancer Center
Kulanui o Chicago Comprehensive Cancer Center
Kulanui o Colorado Cancer Center
Kulanui o Michigan Comprehensive Cancer Center
Kulanui o North Carolina Lineberger Comprehensive Cancer Center
Kulanui o Oklahoma - Stephenson Cancer Center
Kulanui o Pittsburgh Cancer Institute
Kulanui o Rochester Wilmot Cancer Institute
Kulanui o Kaleponi Hema - Norris Comprehensive Cancer Center
Kulanui o Texas MD Anderson Cancer Center
Kulanui o Texas Southwestern Medical Center - Harold C. Simmons Cancer Center
Kulanui o Utah - Huntsman Cancer Institute
Kulanui o Wisconsin Carbone Cancer Center
Ke Kulanui Lapaʻau Kula ʻo Vanderbilt - Hale Waʻa Kanu ʻo Vanderbilt Ingram
Ke Kulanui o Wakinekona ma St. Louis - Siteman Cancer Center
ʻO Wayne State University Barbara Ann Karmanos Cancer Institute
Ke Kulanuiʻo Yale - Yale Cancer Center
ʻO nā pae kiʻekiʻe o ke kākau inoa ʻana o ka mea maʻi e koi i kahi pae hoʻomau o ka hana hoʻokele ʻikepili i loko o kekahi mau makahiki, a ke kākoʻo nei nā hāʻawi LAPS i nā limahana noiʻi e pono ai e hoʻokele i kēia hana. ʻO nā kālā i hāʻawi ʻia i nā hāʻawi LAPS e uhi i kēia hoʻonui ʻia o ka hana e hoʻonui pono i ka pae o ka uku o ka mea maʻi ma nā pūnaewele i koho ʻia.
Hāʻawi pū nā makana LAPS i kekahi kālā no ke alakaʻi ʻepekema a me ka alakaʻi ma ka pūnaewele ponoʻī, ʻoiai nā mea noiʻi nui ma ka pūnaewele e pono e hoʻonohonoho mua i nā hoʻokolohua hoʻokolohua a lākou e komo ai, a me ke aʻo ʻana a hoʻomaʻamaʻa i nā limahana ma nā pūnaewele i ka noiʻi noiʻi a hoʻomohala. nā hoʻolālā e hāpai i ke kākau inoa ʻana o ka mea maʻi.
Nā Halemai Kaiāulu a me nā Hale Lapaʻau
Hiki i nā mea noiʻi ʻē aʻe ma nā haukapila kaiāulu a me nā kikowaena olakino ke komo i nā hoʻokolohua NCTN, ʻoiai aia lākou ma nā pūnaewele i loaʻa ʻole kahi makana LAPS. Loaʻa kēia mau pūnaewele, a me kekahi o nā pūnaewele o ka honua, a loaʻa pololei paha kahi uku noiʻi mai kekahi o nā hui pūnaewele a lākou e pili ai a i ʻole loaʻa iā lākou nā makana mai ka NCI Community Oncology Research Program (NCORP).
ʻO ka lālā o ka pūnaewele i nā hui NCTN pākahi e pili ana i nā ana kikoʻī i kikoʻī ʻia i kēlā me kēia hui. Hiki i nā pūnaewele ke hoʻāʻo nei i nā hoʻokolohua hoʻokolohua ke komo i kahi hui ma mua o hoʻokahi, a ʻo ka lālā ma ka liʻiliʻi o hoʻokahi pūʻulu e ʻae i kahi pūnaewele e komo i nā hoʻokolohua i alakaʻi ʻia e nā hui NCTN āpau i kūpono ai kā lākou mea noiʻi. No laila, ʻo nā mea noiʻi mai ka LAPS, NCORP, nā wahi aʻo ʻē aʻe, nā hana kaiāulu, a me nā lālā o ka honua e pili pū ana me nā hui Pūnaewele e hoʻokomo i nā mea maʻi i nā hoʻokolohua NCTN.
Pūʻulu Kuhi Oncology Imaging a me Radiation (IROC)
E kōkua i ka nānā ʻana a me ka hōʻoia ʻana i ka maikaʻi ma nā hoʻāʻo e pili ana i nā ʻano kiʻi hou a me / a i ʻole radiation therapy, ua hoʻokumu ʻo NCTN i kahi Imaging and Radiation Oncology Core (IROC) GroupExit Disclaimer e kōkua i nā hui NCTN āpau e hoʻohana i kēia mau hana i kā lākou mau hoʻāʻo.
Nā Makana ʻEpekema Unuhi Unuhi (ITSA)
ʻO ka ʻāpana hope loa o ka NCTN ʻo ia nā Award Science Science Integrated (ITSAs). ʻO nā hui ʻelima i loaʻa iā ITSA nā hui o ka ʻepekema unuhi i hoʻohana i nā ʻenehana hou, proteomic, a me nā ʻenehana kiʻi e kōkua e ʻike a kūpono i nā biomarkers wānana mua o ka pane i ka therapy i hiki i nā hui pūnaewele ke hoʻohui i nā hoʻokolohua hoʻokolohua e hiki mai ana.
Hoʻohana ʻia kēia mau makana e leverage i ka hana i hoʻomaka ʻia ma nā keʻena hoʻokolohua o kēia mau mea noiʻi, i kākoʻo pinepine ʻia e kekahi ʻāpana e nā hāʻawi kālā NCI ʻē aʻe, me ka manaʻo e kōkua kēia mau mea noiʻi i nā hui pūnaewele e lawe i nā ʻike hou o ka hale hana i nā hoʻokolohua hoʻokolohua. Hoʻohana kēia mau labs āpau i nā ʻenehana hōʻoki e hiki ai ke hōʻike maikaʻi ʻia o nā tumors a kōkua e ʻike i nā loli i ka biology tumo i ka pane ʻana i ka lāʻau e kōkua ai i ka wehewehe ʻana pehea e ulu ai ke kūʻē ʻana.
ʻO nā mea kōkua ITSA:
Ka Halemai Kamaliʻi o PhiladelphiaExit Disclaimer
Ke Kulanui Emory - Winship Cancer InstituteExit Disclaimer
Kahi hoʻomanaʻo maʻi maʻi maʻi ʻo Sloan Ketter Cancer Center
Ke Kulanui ʻ Cancerlelo Nui ʻo Ohio State University Comprehensive Cancer Center
Kulanui o North Carolina Lineberger Comprehensive Cancer CenterExit Disclaimer
Nā Panakō Nūhou NCTN
Hōʻiliʻili pū kēlā me kēia hui NCTN a mālama i nā mea mai nā mea maʻi i nā hoʻokolohua NCTN i kahi kikowaena o nā panakō kikoʻī. Ua hoʻomohala ʻia nā kuʻina maʻamau e hōʻoia i ka maikaʻi o nā kiko i hōʻiliʻili ʻia. ʻO nā moʻolelo kamepiula o nā laʻana i mālama ʻia he mau kikoʻī koʻikoʻi, e like me nā lāʻau i loaʻa i nā mea maʻi mai lākou mai i lawe ʻia ai ke kino, ka hopena o ka lāʻau, a me ka hopena o ka hoʻomanawanui. Hiki i nā poʻe komo i nā hoʻokolohua NCTN ke ʻae i ka hoʻohana ʻana i kā lākou kiko kiko no ka hoʻopaʻa ʻana ma ʻō aku o ka hoʻokolohua NCTN a lākou i kākau inoa ai. Aia pū ka papahana panakō kikoʻī ʻo NCTN i kahi ʻōnaehana pūnaewele i hiki i kekahi mea noiʻi ke hoʻohana. Nā kānaka noiʻi, me nā mea i pili ʻole i ka NCTN,
Nā Kōmike Hoʻokele ʻepekema
Hāʻawi nā hui NCTN i nā manaʻo no nā hoʻokolohua hoʻokolohua hou i nā Kōmike Hoʻokele maʻi NCI / Imaging. Hoʻonohonoho ʻia kēia mau kōmike e NCI e loiloi a hoʻonohonoho mua i nā hoʻokolohua hoʻokolohua hou a koi aku iā NCI i ka poʻe i loaʻa ka hopena ʻepekema kiʻekiʻe loa. Alakaʻi ʻia kēlā me kēia kōmike e nā hoa noho nongovernmental i ʻae ʻole ʻia e hoʻopaʻa i nā kūlana alakaʻi i nā hui NCTN, ʻoiai he lālā lālā lākou. ʻO ke koena o ke kōmike lālā o nā lālā o ka hui NCTN i koho ʻia e kēlā me kēia hui, nā loea maʻi ʻē aʻe i pili ʻole i nā kūlana alakaʻi i nā hui, nā ʻelele o ka NCI-i kākoʻo kālā ʻia ʻo SPORE a me Consortia, nā biostatisticians, nā mea kōkua hoʻomanawanui, a me nā loea maʻi NCI.
NCTN Palapala Waihona
ʻO ka nui o ka moʻohelu kālā NCTN he $ 171 miliona, i hāʻawi ʻia i nā ʻāpana like ʻole o ka pūnaewele. Hāʻawi kēia ʻōnaehana i kahi papa inoa makahiki makahiki ma kahi o 17,000-20,000 i komo i ka mālama maʻi ʻaʻai a me nā hoʻokolohua kiʻi.
Nā hana i ka laulima ʻana
Hiki i nā hui NCTN ke hōʻemi i nā kumukūʻai no ke alakaʻi ʻana i nā hoʻokolohua ma ka kaʻana like ʻana i nā kumuwaiwai. Hāʻawi kēia ala hana like i nā lālā o hoʻokahi hui NCTN e kākoʻo i nā hoʻokolohua i alakaʻi ʻia e nā hui ʻē aʻe a hāʻawi i nā lālā NCTN i ka hiki ke alakaʻi i kahi kōpena o nā hoʻokolohua i nā maʻi maʻi maʻamau.
Ma muli o ka loaʻa ʻana o nā hui mākua ʻehā o ka NCTN, me ka liʻiliʻi o nā keʻena hana a me nā helu helu e koi ai i ke kākoʻo kālā, ua loaʻa kahi mālama kālā net. Hoʻohana nā hui āpau i kahi ʻōnaehana mālama ʻike maʻamau (Medidata Rave) a me kahi ʻōnaehana IT i hoʻohui ʻia no nā panakō kikoʻī, kahi e unuhi ai i ka mālama kālā.
Kākoʻo hou
He paʻakikī nā hoʻokolohua hoʻokolohua e koi ai i kahi hui o nā hui kākoʻo a me nā kahawai kālā. Aia i loko o ka pūnaewele kahi mau hiʻohiʻona ʻē aʻe i pili ʻole i nā makana NCTN akā he mea nui ia i ka hoʻokō ʻana i ka nuʻukia NCTN.
Loaʻa i ke kākoʻo hou aʻe:
- Nā Papa Nānā Kūloko Kūloko, kahi mea nui o ka ʻōnaehana hoʻokolohua hoʻokolohua a NCI e hoʻohui i ka wikiwiki, ka maikaʻi, a me ka like ʻana i ka loiloi etika.
- ʻO ka Unit Support Trials Cancer (CTSU), kahi ʻaelike kālā i hāʻawi kālā ʻia no NCI e hāʻawi ana i nā mea noiʻi maʻi a me kā lākou limahana me ke komo ʻana ma kahi pūnaewele hoʻokahi i nā hoʻokolohua NCTN a ʻae i nā mea noiʻi e hoʻopaʻa inoa i nā mea maʻi hou.
- Hāʻawi kālā ʻia kahi pēke kikoʻī hoʻolaʻa ʻia no kēlā me kēia hui Pūnaewele ma o kahi ʻano makana NCI ʻokoʻa.
- ʻO ka Biomarker, Imaging, a me ka maikaʻi o ka Polokalamu Kālā ʻImi Ola (BIQSFP), kahi kahawai hoʻokaʻawale ʻokoʻa no nā hoʻokolohua NCTN e kākoʻo ana i nā noiʻi ʻepekema pilina ma nā hoʻāʻo ʻana o ka hui. Hoʻokūkū nā hui NCTN no nā kālā i mālama ʻia i kēlā me kēia makahiki no kēia kumu. ʻO ka loaʻa ʻana o nā kālā hoʻolaʻa e hoʻoikaika nui i ka hoʻonohonoho ʻana, ʻoiai ʻo nā hoʻokolohua hoʻokolohua pono e hoʻokō i nā lā palena palena.
- Hoʻohui ʻia, ma kahi o hoʻokahi hapahā o ka hōʻemi accrual ma nā hoʻokolohua lapaʻau NCTN e uku ʻia e ka papahana NCORP. Hoʻihoʻi ʻia nā halemai kaiāulu a me nā kikowaena lapaʻau e komo ana i ka papahana NCORP no ka hōʻiliʻili ʻana i nā mea maʻi i nā hoʻokolohua lapaʻau NCTN e kā lākou mau makana NCORP, ʻaʻole ma o ka makana NCTN Group Operations.
Finally, in addition to these substantial annual expenditures, NCI also subsidizes the NCTN by paying for many other essential clinical trial functions, thereby further reducing costs borne by the Network groups:
- NCI pays for the licenses and hosting fees of the electronic, common data management system, called Medidata Rave, used by all of the NCTN groups.
- NCI oversees a national audit system for NCTN trials.
- NCI manages Investigational New Drug applications to the Food and Drug Administration along with the distribution of these drugs for many NCTN trials.
ʻO ka laulima ʻana ma waena o nā hui i ʻike ʻia he koʻikoʻi i ka kūleʻa ma nā pae hoʻonohonoho āpau a ke uku ʻia nei ia i ka manawa o ka loiloi hāʻawi. Hoʻomaopopo pū ʻia ka mākaukau, a aia nā manawa palena manawa i kēia manawa no ka hoʻomohala ʻana i ka protocol. ʻOiai ke nānā ʻia kēia mau hoʻololi he mea nui no ke olakino o ka ʻōnaehana lehulehu, hiki mai lākou i kahi manawa kūpono, no ka mea ke hāʻawi nei nā loli pīhoihoi i ka ʻepekema oncologic i nā ala hou no ka holomua wikiwiki, keu hoʻi no ka hoʻomohala ʻana i nā ʻōnaehana ʻōnaehana hou.
