About-cancer / lapaʻau / clinical-hoʻokolohua / maʻi / extragonadal-germ-cell-cell-tumors / lapaʻau

Hoʻomaʻamaʻa i nā hoʻokolohua lapaʻau no ka Tumelet Cell Extragonadal

ʻO nā hoʻokolohua hoʻokolohua kahi noiʻi noiʻi e pili ana i ka poʻe. ʻO nā hoʻokolohua hoʻokolohua ma kēia papa inoa no ka hoʻomaʻemaʻe tumora cell germ extragonadal. Kākoʻo ʻia nā hoʻokolohua āpau ma ka papa inoa e NCI.

ʻO ka ʻike pili o NCI e pili ana i nā hoʻokolohua hoʻokolohua e wehewehe i nā ʻano a me nā pae o nā hoʻokolohua a pehea e lawe ai. Nānā nā hoʻāʻo hoʻokolohua i nā ala hou e pale ai, ʻike ai, a mālama ai paha i ka maʻi. E makemake paha ʻoe e noʻonoʻo e pili ana i ka lawe ʻana i ka hoʻokolokolo hoʻokolohua. E kamaʻilio me kāu kauka no ke kōkua i ka hoʻoholo ʻana inā kūpono kekahi iā ʻoe.

Nā hoʻāʻo 1-7 o 7

Nānā ʻeleu, Bleomycin, Carboplatin, Etoposide, a i ʻole Cisplatin i ka mālama ʻana i nā Pediatric a me nā mea maʻi makua me nā Tumors Cell Germ.

Ke aʻo nei kēia mahele hoʻokolohua III i ka nānā pono ʻana o ka hana, bleomycin, carboplatin, etoposide, a i ʻole cisplatin hana i ka mālama ʻana i nā mea maʻi pediatric a me nā mākua me nā tumors cell germ. Hiki ke kōkua i ka nānā ʻana i nā kauka e nānā i nā kumuhana me nā tumors germ germ liʻiliʻi ma hope o ka hemo ʻana o kā lākou tumo. ʻO nā lāʻau i hoʻohana ʻia i ka chemotherapy, e like me bleomycin, carboplatin, etoposide, a me cisplatin, hana i nā ala like ʻole e hōʻoki ai i ka ulu ʻana o nā hunaola tumora, ma ka luku ʻana paha i nā hunaola, ma ke kāpae ʻana iā lākou mai ka hoʻokaʻawale ʻana, a i ʻole ke kāpae ʻana iā lākou mai ka hoʻolaha ʻana.

Kahi: 435 mau wahi

Hoʻoikaika ʻia a maʻamau ʻia ʻo BEP Chemotherapy i ka mālama ʻana i nā mea maʻi me nā tumors a me nā Tumor-Risk Metastatic Germ Cell Tumors.

Ke aʻo nei kēia pae III i ka hoʻokolohua ʻana i ka maikaʻi o ka wikiwiki o ka bleomycin sulfate, ka etoposide phosphate, a me ka cisplatin (BEP) chemotherapy e hoʻohālikelike ʻia i ka papa kuhikuhi maʻamau o ka BEP chemotherapy i ka mālama ʻana i nā mea maʻi me nā tumors cell germengah waena a maikaʻi ʻole paha i pāhola ʻia i kekahi. nā wahi i ke kino (metastatic). ʻO nā lāʻau i hoʻohana ʻia i ka chemotherapy, e like me ka bleomycin sulfate, ka etoposide phosphate, a me ka cisplatin, hana i nā ala like ʻole e hōʻoki ai i ka ulu ʻana o nā hunaola tumora, ma ka pepehi ʻana paha i nā hunaola, ma ke kāpae ʻana iā lākou mai ka hoʻokaʻawale ʻana, a i ʻole ke kāpae ʻana iā lākou mai ka hoʻolaha ʻana. ʻOi aku ka maikaʻi o ka hāʻawi ʻana i ka chemotherapy BEP ma kahi wikiwiki, a i ʻole "hōʻeleu" ʻia me ka liʻiliʻi o nā hopena i ka mālama ʻana i nā mea maʻi me nā tumors cell germ waena a i ʻole maikaʻi ʻole i hoʻohālikelike ʻia i ka papahana maʻamau.

Kahi: 126 mau wahi

ʻO Chemotherapy Hoʻohui Kūlana Kūlana Kūlana Kūlana ʻo Chemotherapy a me High-Dose Combination Chemotherapy a me Stem Cell Transplant i ka mālama ʻana i nā mea maʻi me nā Tumors Cell Germ Refractory a Cell

Ke nānā nei kēia pae III i ka hoʻokolohua ʻana i ka maikaʻi o ka hana ʻana o ka chemotherapy ma ka hoʻohālikelike ʻana i ka chemotherapy kiʻekiʻe a me ka transplant cell stem i ka mālama ʻana i nā mea maʻi me nā tumors cell germ i hoʻi mai ma hope o kahi manawa o ka hoʻomaikaʻi a pane ʻole paha i ka lāʻau. ʻO nā lāʻau i hoʻohana ʻia i ka chemotherapy, e like me paclitaxel, ifosfamide, cisplatin, carboplatin, a me etoposide, hana i nā ʻano like ʻole e hōʻoki ai i ka ulu ʻana o nā hunaola tumora, ma ka luku ʻana paha i nā hunaola, ma ke kāpae ʻana iā lākou mai ka hoʻokaʻawale ʻana, a i ʻole ke kāohi ʻana iā lākou mai ka hoʻolaha ʻana. ʻO ka hāʻawi ʻana i ka chemotherapy ma mua o kahi transplant cell stem e hoʻōki i ka ulu ʻana o nā hunaola maʻi ʻaʻai e ka hoʻokū ʻana iā lākou mai ka hoʻokaʻawale a pepehi paha iā lākou. Ke hāʻawi nei i nā mea hoʻonāukiuki i nā kolone, e like me filgrastim a i ʻole pegfilgrastim, a me kekahi mau lāʻau chemotherapy, kōkua i nā neʻe kūmole e neʻe mai ka iwi o ka iwi i ke koko i hiki ai iā lākou ke ʻohi a mālama. Hāʻawi ʻia ʻo Chemotherapy e hoʻomākaukau i ka iwi iwi no ka transplant cell stem. Hoʻihoʻi ʻia nā hunaola i ka mea maʻi e pani i nā hunaola koko i luku ʻia e ka chemotherapy. ʻAʻole i ʻike ʻia inā ʻoi aku ka maikaʻi o ka chemotherapy a me ka transplant cell stem iʻoi aku ka maikaʻi ma mua o ka maʻamau maʻamau o ka chemotherapy hui pū i ka mālama ʻana i nā mea maʻi me nā tumors cell germ refractory a relapsed paha.

Kahi: 54 mau wahi

ʻO Durvalumab a me Tremelimumab i ka mālama ʻana i nā mea maʻi me nā Tumors Kelepona Kelepona Hou a Refractory paha

Ke aʻo nei kēia mahele II i ka maikaʻi o ka hana durvalumab a me ka tremelimumab i ka mālama ʻana i nā mea maʻi me nā tumors cell germ i hoʻi mai ma hope o kahi manawa o ka hoʻomaikaʻi a pane ʻole paha i ka lāʻau. Immunotherapy me nā monoclonal antibodies, e like me ka durvalumab a me ka tremelimumab, hiki ke kōkua i ke kino ʻōnaehana pale kaua i ka maʻi ʻaʻai, a hiki ke hoʻopilikia i ka hiki i nā tumola ke ulu a pālahalaha.

Kahi: 7 mau wahi

Ke Keʻokeʻo Pepa Pēhē Autologous Peripheral Blood Stem no nā Tumula Pūnaewele Kelemona

ʻO nā koho lapaʻau no ka hoʻihoʻi ʻia a i ʻole nā ​​refractory germ cell tumors (GCT) ka palena o nā mea maʻi. ʻO ka chemotherapy kiʻekiʻe loa me ka hoʻopakele ʻana o ka cell stem (autologous cell cell transplant), ke hāʻawi ʻia me ke kaʻina, ua hōʻike ʻia e hiki ke hoʻōla ʻia kahi ʻāpana o nā mea maʻi. ʻO ka regima chemotherapy kiʻekiʻe loa maikaʻi, eia naʻe, ʻike ʻole ʻia. I kēia hoʻokolokolo ʻana, e hoʻohana mākou i nā transplants autologous tandem me nā regimens hoʻopale keʻa keʻa ʻole e mālama i nā mea maʻi me nā GCT i hoʻi hou ʻia / refactory.

Kahi: Kulanui o Minnesota / Masoner Cancer Center, Minneapolis, Minnesota

Melphalan, Carboplatin, Mannitol, a me Sodium Thiosulfate i ka mālama ʻana i nā mea maʻi me ka CNS Embryonal a i ʻole nā ​​Tumors Cell Germ.

Ke aʻo nei kēia mahele I / II i nā hopena a me ka mahele lāʻau maikaʻi loa o ka melphalan ke hāʻawi ʻia me ka carboplatin, mannitol, a me ka sodium thiosulfate, a e ʻike i ka maikaʻi o kā lākou hana ʻana i ka mālama ʻana i nā mea maʻi me ka ʻōnaehana kikowaena waena hou a holomua (CNS) embryonal a germ paha. ʻāpala pūnana. ʻO nā lāʻau i hoʻohana ʻia i ka chemotherapy, e like me melphalan a me ka carboplatin, hana i nā ʻano like ʻole e hōʻoki i ka ulu ʻana o nā hunaola tumora, ma ka luku ʻana paha i nā hunaola, ma ke kāpae ʻana iā lākou mai ka hoʻokaʻawale ʻana, a i ʻole ke kū ʻana iā lākou mai ka hoʻolaha ʻana Hoʻohana ka Osmotic Blood-otak barrier disruption (BBBD) i ka mannitol e wehe i nā kīʻaha koko a puni ka lolo a ʻae e lawe pololei i nā mea pepehi kanaka maʻi maʻi i ka lolo. Hiki i ka Sodium thiosulfate ke kōkua i ka hoʻoliʻiliʻi a pale ʻana i ka nalo ʻana o ka lohe a me nā mea ʻino i nā mea maʻi e hana ana i ka chemotherapy me ka carboplatin a me BBBD.

Kahi: 2 mau wahi

ʻO Adjuvant Tumor Lysate Vaccine a me Iscomatrix me a i ʻole Metronomic Oral Cyclophosphamide a me Celecoxib i nā mea maʻi me nā malignancies e pili ana i nā puʻuwai, Esophagus, Pleura, a Mediastinum

ʻIke Kahua: I nā makahiki i hala iho nei, ua kū mai nā antigens cancer-testis (CT) (CTA), ʻo ia hoʻi nā mea i hoʻopili ʻia e nā ʻāpana ma nā X chromosome (CT-X genes) i mau māka maikaʻi no ka maʻi pale maʻi maʻi maʻi. ʻOiai hōʻike hewa nā malology o nā histologies like ʻole i nā ʻano CTA like ʻole, ʻike ʻole ʻia nā pane pale ʻole i kēia mau protein i nā mea maʻi maʻi ʻaʻai, ma muli paha o ka pae haʻahaʻa, heterogeneous antigen expression, a me nā pūnaewele T hoʻomalu pale pale i loaʻa i loko o nā wahi tumor a me ka ʻōnaehana ʻōnaehana o kēia mau kānaka. . Hoʻohālikelike, ka lāʻau ʻana o nā mea maʻi ʻaʻai me nā pūhaka tuma e hōʻike ana i nā kiʻekiʻe kiʻekiʻe o CTA i ka hui pū ʻia me nā regimens e hoʻopau a kāohi paha i nā pūnaewele hoʻokele T e hoʻoulu i ka pale ākea i kēia mau antigen. I mea e nānā ai i kēia pilikia, ʻo nā mea maʻi me nā maʻi ʻāpā mua a me nā maʻi ʻeha esophageal, nā mesotheliomas pleura, nā sarkoma thoracic, nā neoplasms thymic a me nā tumors cell germast germ germ, a me nā sarcomas, melanomas, tumor cell tumors, a i ʻole nā ​​epithelial malignancies metastatic i nā akemāmā, pleura a me mediastinum me ka hōʻike ʻole o ka maʻi (NED) a i ʻole ka maʻi residual liʻiliʻi (MRD) e pili ana i ka maʻamau multidisciplinary therapy. lāʻau lapaʻau me ka H1299 pūnana lysates me ka mea kōkua Iscomatrix E lawelawe ʻia nā lāʻau lapaʻau me ka ʻole o ka metronomic oral cyclophosphamide (50 mg PO BID x 7d q 14d), a me ka celecoxib (400 mg PO BID). ʻO nā pane Serologic i nā ʻano CTA recombinant like hoʻi a me nā pane immunologic i ka tumo autologous a i ʻole epigenetically hoʻololi ʻia nā autologous EBVtransformed lymphocytes e loiloi ʻia ma mua a ma hope o ka piha ʻana o ʻeono mau mahina. Nā Pahuhopu Nui: 1. No ka loiloi i ke alapine o nā pane immunologic i CTA i nā mea maʻi me nā maʻi ʻōpū ma hope o nā lāʻau āpau me nā lāʻau H1299 cell lysate / Iscomatrix (TM) wale nō i ka hoʻohālikelike ʻana i nā mea maʻi me nā maʻi kūpikipiki e pili ana i nā lāʻau lapaʻau me ka H1299 cell lysate / Iscomatrix vaccine me ka metronomic cyclophosphamide a me celecoxib . N Object Pahuhopu Nui: 1. Ninaninau inā hoʻoliʻiliʻi ka metronomic cyclophosphamide a me ka celecoxib therapy i ka helu a me ka pākēneka o nā pūnaewele mālama T a hōʻemi i ka hana o kēia mau hunaola i nā mea maʻi me nā maʻi kūpikipiki e makaʻu i ka hoʻi hou. 2. No ka nānā ʻana inā H1299 cell lysate / Iscomatrix (TM) hoʻomaikaʻi i ka pane immunologic i ka tumo autologous a i ʻole epigenetically hoʻololi autologous EBV-transformed lymphocytes (B cells). Kūpono: - ʻO nā mea maʻi me ka histologically a cytologically paha i hōʻoia i ka liʻiliʻi liʻiliʻi a i ʻole ka liʻiliʻi liʻiliʻi o ka maʻi ʻaʻai (SCLC; NSCLC), maʻi ʻaʻai esophageal (EsC), mesothelioma pleural malignant (MPM), thymic a i ʻole mediastinal germ cell tumors, thoracic sarcomas, a melanomas, sarcomas, a i ʻole nā ​​epithelial malignancies metastatic i nā akemāmā, pleura a i ʻole mediastinum ʻaʻohe o lākou hōʻike hōʻike maʻi o ka maʻi ʻeleu (NED), a i ʻole maʻi liʻiliʻi residual (MRD) i hiki ʻole ke kiʻi ʻia e nā biopsy non-invasive a i ʻole resection / radiation ma hope o ka hoʻomaʻamaʻa maʻamau i hoʻopau ʻia i loko o nā 26 mau pule i hala. . - Pono nā mea maʻi i 18 mau makahiki a ʻoi paha me kahi kūlana hana ECOG o 0 2. - Pono i nā maʻi ke loaʻa ka iwi iwi, nā puʻuwai, ke ake, ka māmā a me ka hana naʻau. - ʻAʻole paha nā mea maʻi ma nā ʻōnaehana immunosuppressive ʻōnaehana i ka hoʻomaka ʻana o nā lāʻau lapaʻau ʻana. Hoʻolālā: - Ma hope o ke ola ʻana mai ke ʻoki kino, chemotherapy, a chemo / XRT, nā mea maʻi me NED a i ʻole MRD e kanikau ʻia ma o ka hoʻokomo ʻana iā IM me nā lysates pūnaewele H1299 a me ka mea kōkua Iscomatrix (TM) i kēlā me kēia mahina no 6 mau mahina. - E lawelawe ʻia nā lāʻau lapaʻau me a i ʻole me ka metronomic oral cyclophosphamide a me ka celecoxib. - E hoʻopaʻa leo ʻia nā ʻōnaehana ʻōnaehana a me ka pane immunologic i ka therapy. Hoʻonohonoho ʻia nā pane o ka serologic a me ka cell i nā pane i kahi panela maʻamau o nā antigens CT a me nā cell tumolog autologous (inā loaʻa) a me nā lymphocytes e hoʻololi ʻia ʻo EBV e loiloi ʻia ma mua a ma hope o ka lāʻau ʻana. - Helu ʻia nā helu / pākēneka a me nā hana o nā hunaola T i ke koko ākea ma mua, i ka wā, a ma hope o nā lāʻau āpau. - E ukali nā mea maʻi i ka haukapila me ka scans staging maʻamau a hiki i ka hoʻi hou ʻana o ka maʻi.

Kahi: National Institutes of Health Clinical Center, Bethesda, Maryland