Types/leukemia/patient/cll-treatment-pdq

Magungunan cutar sankarar bargo na yau da kullun (®) –Patient Version

Janar Bayani Game da Ciwon Cutar sankarar Lempicytic

MAGANAN MAGANA

• Kwayar cutar sankarar bargo ta lymphocytic leukemia wani nau'in ciwon daji ne wanda kashin ƙashi yake yin lymphocytes dayawa (wani nau'in farin jini).

• Cutar sankarar bargo na iya shafar jajayen ƙwayoyin jini, fararen ƙwayoyin jini, da kuma platelets.

• Yawan tsufa na iya shafar haɗarin ɓarkewar cutar sankarar bargo ta lymphocytic.

• Alamomi da alamomin cutar sankarar bargo ta lymphocytic leukemia sun hada da kumburin lymph node da gajiya.

• Ana amfani da gwaje-gwajen da ke bincikar jini, da kashin ƙashi, da kuma lymph nodes don tantance cutar sankarar bargo ta lymphocytic.

• Wasu dalilai suna shafar zaɓuɓɓukan magani da hangen nesa (damar dawowa).

Kwayar cutar sankarar bargo ta lymphocytic leukemia wani nau'in ciwon daji ne wanda kashin ƙashi yake yin lymphocytes dayawa (wani nau'in farin jini).

Kwayar cutar sankarar bargo ta lymphocytic (wanda kuma ake kira CLL) cuta ce ta jini da kasusuwa wanda yawanci yakan zama sannu a hankali. CLL shine ɗayan sananniyar cutar sankarar bargo a cikin manya. Yana faruwa sau da yawa yayin ko bayan matsakaiciyar shekaru; ba safai yake faruwa ga yara ba.

Anatomy na kashi. Kashin ya kunshi karamin kashi, kashin baya, da kashin baya. Karamin kashi yana yin layin waje na ƙashi. Ana samun kashin Spongy galibi a ƙarshen ƙasusuwa kuma yana ɗauke da jajaja. Ana samun kasusuwan kasusuwa a tsakiyar mafi yawan kasusuwa kuma yana da jijiyoyi da yawa. Akwai kashin kashi biyu: ja da rawaya. Jan kashin jini ya ƙunshi ƙwayoyin jini wanda zai iya zama jajayen ƙwayoyin jini, fararen ƙwayoyin jini, ko platelets. An sanya kasusuwan rawaya mafi yawan mai.

Cutar sankarar bargo na iya shafar jajayen ƙwayoyin jini, fararen ƙwayoyin jini, da kuma platelets. A yadda aka saba, jiki yana sanya ƙwayoyin jini na jini (ƙwayoyin da ba su balaga ba) waɗanda suka zama ƙwararrun ƙwayoyin jini akan lokaci. Stemwayar ƙwayar ƙwayar jini na iya zama ƙwayar ƙwayar myeloid ko ƙwayar ƙwayar ƙwayar lymphoid.

Kwayar kara kuzari ta myeloid ta zama ɗayan nau'ikan nau'ikan ƙwayoyin jini uku masu girma:

• Jajayen jini wadanda suke daukar iskar oxygen da sauran abubuwa zuwa dukkan kyallen takarda.

• Farin jini wanda ke yakar kamuwa da cuta.

• Platelets wadanda suke samar da daskararren jini dan tsaida zubar jini.

Kwayar kwayar lymphoid ta zama kwayar lymphoblast sannan ɗayan nau'ikan ƙwayoyin lymphocytes guda uku (fararen ƙwayoyin jini):

• B lymphocytes wanda ke yin rigakafi don taimakawa yaƙi da kamuwa da cuta.

• T lymphocytes masu taimakawa B lymphocytes suna yin rigakafi don yaƙar kamuwa da cuta.

• Kwayoyin kisa na halitta wadanda ke kai hari kan ƙwayoyin daji da ƙwayoyin cuta.

Ci gaban kwayar jini. Kwayar sel ta jini tana wucewa ta matakai da yawa don zama jajayen jini, platelet, ko kuma farin jini.

A cikin CLL, ƙwayoyin jini da yawa sun zama ƙwayoyin cuta marasa kyau kuma basu zama lafiyayyun ƙwayoyin jini ba. Hakanan ana iya kiran ƙwayoyin cuta marasa kyau na cutar sankarar bargo. Lymphocytes basu iya yaƙar kamuwa da cuta sosai. Hakanan, yayin da yawan kwayar halittar lymphocytes ke ƙaruwa a cikin jini da ƙashin ƙashi, akwai ƙarancin wuri don lafiyayyun ƙwayoyin jini masu kyau, jajayen ƙwayoyin jini, da platelets. Wannan na iya haifar da kamuwa da cuta, karancin jini, da kuma saurin zubar jini.

Wannan taƙaitaccen bayani ne game da cutar sankarar bargo ta lymphocytic. Duba takaitattun masu zuwa don ƙarin bayani game da cutar sankarar bargo:

• Kulawa da Ciwon Cutar sankarar bargo na manya.

• Kulawa da Ciwon Cutar sankarar bargo yara.

• Kulawa da Ciwon Cutar sankarar Myeloid na Matasa.

• Yaran Ciwon Cutar Myeloid Mai Ciwo / Sauran Maganin Cutar Myeloid.

• Magungunan cutar sankarar bargo na zamani.

• Jiyya Kwayar Cutar sankarar bargo

Yawan tsufa na iya shafar haɗarin ɓarkewar cutar sankarar bargo ta lymphocytic.

Duk wani abu da zai kara maka hadarin kamuwa da cuta to ana kiran sa mai hadari. Samun haɗari ba ya nufin cewa za ku kamu da cutar kansa; ba tare da haɗarin abubuwan haɗari ba yana nufin cewa ba zaku sami cutar kansa ba. Yi magana da likitanka idan kuna tsammanin kuna iya fuskantar haɗari. Abubuwan haɗari ga CLL sun haɗa da masu zuwa:

• Kasancewa mai matsakaiciyar shekaru ko babba, namiji, ko fari.

• Tarihin iyali na CLL ko ciwon daji na tsarin lymph.

• Samun dangi waɗanda yahudawan Rasha ne ko yahudawan Yammacin Turai.

Alamomi da alamomin cutar sankarar bargo ta lymphocytic leukemia sun hada da kumburin lymph node da gajiya.

Yawancin lokaci CLL baya haifar da alamu ko alamomi kuma ana samun sa yayin gwajin jini na yau da kullun. Alamu da alamomi na iya faruwa ta hanyar CLL ko ta wasu yanayi. Duba tare da likitanka idan kuna da ɗayan masu zuwa:

• Swellingwanƙwasa ƙwayoyin lymph a cikin wuya, maras kyau, ciki, ko makwancin ciki.

• Jin kasala sosai.

• Jin zafi ko cika a ƙasa da haƙarƙarin.

• Zazzabi da kamuwa da cuta.

• Rashin nauyi ba tare da wani dalili da aka sani ba.

Ana amfani da gwaje-gwajen da ke bincikar jini, da kashin ƙashi, da kuma lymph nodes don tantance cutar sankarar bargo ta lymphocytic.

Za a iya amfani da waɗannan gwaje-gwajen da hanyoyin:

• Jarabawa ta jiki da tarihin lafiya: Jarabawa ta jiki don bincika alamomin lafiya gaba ɗaya, gami da bincika alamun cuta, kamar kumburi ko wani abu da kamar baƙon abu. Za a kuma ɗauki tarihin al'adun lafiyar marasa lafiya da cututtukan da suka gabata da magunguna.

• Cikakken ƙidayar jini (CBC) tare da banbanci: Hanyar da za'a zana samfurin jini kuma a bincika ta mai zuwa:

• Yawan jajayen kwayoyin jini da platelets.

• Adadi da nau'in farin jini.

• Adadin haemoglobin (furotin da ke ɗauke da iskar oxygen) a cikin ƙwayoyin jinin jini.

• Yankin samfurin jini ya kunshi jajayen ƙwayoyin jini.

Kammala lissafin jini (CBC). Ana tattara jini ta hanyar sanya allura a cikin jijiya da kuma barin jini ya kwarara cikin bututu. Ana aika samfurin jini zuwa dakin gwaje-gwaje kuma ana kidaya ƙwayoyin jinin jini, fararen ƙwayoyin jini, da kuma platelets. Ana amfani da CBC don gwadawa, gano asali, da kuma lura da yanayi daban-daban.

• Immunophenotyping: Gwajin dakin gwaje-gwaje da ke amfani da kwayoyin cuta don gano kwayoyin cutar kansar dangane da nau'ikan antigens ko alamomi a saman sel. Ana amfani da wannan gwajin don taimakawa wajen gano takamaiman nau'ikan cutar sankarar bargo.

• KIFI (haske a cikin yanayin haɗuwa): Gwajin gwaje-gwaje da ake amfani dashi don kallo da ƙididdigar kwayoyin halitta ko chromosomes a cikin ƙwayoyin halitta da kyallen takarda. Ana yin yanki na DNA da ke ɗauke da launuka masu kyalli a cikin dakin gwaje-gwaje kuma an ƙara su zuwa samfurin ƙwayoyin marasa lafiya ko kyallen takarda. Lokacin da wadannan sassan DNA din da aka rina suka hade da wasu kwayoyin halitta ko bangarorin chromosomes a cikin samfurin, suna haskakawa idan aka kalleshi a karkashin madubin hangen nesa. Ana amfani da gwajin FISH don taimakawa wajen gano kansar da kuma taimakawa shirya magani.

• Gudun cytometry: Gwajin dakin gwaje-gwaje wanda ke auna yawan kwayoyin halitta a cikin samfurin, yawan kwayoyin rai a cikin samfurin, da wasu halaye na kwayoyin, kamar girman su, sifar su, da kuma kasancewar ciwace ciwace ciwace (ko wasu) Tantanin tantanin halitta Kwayoyin daga samfurin jinin mai haƙuri, kashin ƙashi, ko wasu kayan suna da datti tare da fenti mai kyalli, sanya shi a cikin ruwa, sannan a wuce ɗaya bayan ɗaya ta hanyar hasken haske. Sakamakon gwajin ya ta'allaka ne akan yadda ƙwayoyin da aka lalata tare da fenti mai kyalli ke amsa ga katangar haske. Ana amfani da wannan gwajin don taimakawa wajen ganowa da kuma sarrafa wasu nau'ikan cutar kansa, kamar cutar sankarar bargo da cutar lymphoma.

• Gwajin maye gurbi na IgVH: Gwajin gwaje-gwaje wanda aka gwada samfurin jini ko nama don wasu canje-canje a cikin kwayar cutar ta IgVH. Marasa lafiya tare da maye gurbi na IgVH suna da kyakkyawan hangen nesa.

• Burin kasusuwan kasusuwa da kuma biopsy: Cire kasusuwan kasusuwa, jini, da karamin guntun kashi ta hanyar sanya allura mara kyau a cikin kashin hanji ko kashin mama. Wani masanin ilimin ɗan adam ya kalli kasusuwan kasusuwa, jini, da ƙashi a ƙarƙashin microscope don neman ƙwayoyin cuta mara kyau.

Burin kasusuwa da biopsy. Bayan an lasafta wani karamin yanki na fata, ana saka allurar kasusuwa ta kashin a cikin kashin hancin mara lafiyar. Ana cire samfurorin jini, kashi, da kashin nama don bincike a karkashin wani madubin likita.

Wasu dalilai suna shafar zaɓuɓɓukan magani da hangen nesa (damar dawowa).

Zaɓuɓɓukan magani sun dogara da:

• Matakin cutar.

• Jan jini, da farin jini, da jinin platelet.

vAmma akwai alamu ko alamomi, kamar zazzaɓi, sanyi, ko rage nauyi.

• Ko hanta, saifa, ko lymph nodes sun fi girma fiye da al'ada.

• Amsar maganin farko.

• Ko CLL ta sake dawowa (dawo).

Hangen nesa ya dogara da:

• Ko akwai canji a cikin DNA da kuma irin canjin, idan akwai daya.

• Ko lymphocytes sun yadu ko'ina cikin ɓacin kashi.

• Matakin cutar.

• Ko CLL ya sami sauki tare da magani ko ya sake dawowa (dawo).

• Ko CLL ya ci gaba zuwa lymphoma ko cutar sankarar bargo ta nakasa.

• Mai haƙuri da shekaru da kuma general kiwon lafiya.

Matakai na cutar sankarar bargo ta Lymphocytic

MAGANAN MAGANA

• Bayan an gano cutar sankarar bargo ta lymphocytic leukemia, ana yin gwaje-gwaje don gano yadda nisan kansa ya bazu cikin jini da ɓarke.

• Ana amfani da matakai masu zuwa don cutar sankarar bargo ta lymphocytic:

• Mataki na 0

• Mataki Na

• Mataki na II

• Mataki na III

• Mataki na IV

Bayan an gano cutar sankarar bargo ta lymphocytic leukemia, ana yin gwaje-gwaje don gano yadda nisan kansa ya bazu cikin jini da ɓarke.

Staging hanya ce da ake amfani da ita don gano yadda cutar kansa ta bazu. Yana da mahimmanci a san matakin cutar don tsara mafi kyawun magani. Za'a iya amfani da gwaje-gwaje masu zuwa a cikin aikin tsayarwa:

• Kirjin x-ray: X-ray na gabobin da kasusuwa a cikin kirji. X-ray wani irin katako ne na katako wanda zai iya ratsa jiki zuwa fim, yana yin hoton wurare a cikin jiki, kamar ƙwayoyin lymph.

• MRI (hoton maganadisu ): Hanya ce wacce ke amfani da maganadisu, raƙuman rediyo, da kuma kwamfuta don yin jerin hotuna dalla-dalla na wurare a cikin jiki, kamar ƙwaƙwalwa da laka. Wannan hanya ana kiranta kuma ana kiranta hoton maganadisu na maganadisu (NMRI).

• CT scan (CAT scan): Hanya ce da ke yin jerin hotuna dalla-dalla na wurare a cikin jiki, waɗanda aka ɗauka daga kusurwa daban-daban. Ana yin hotunan ne ta wata kwamfuta da aka haɗa ta da na'urar da ke ɗauke da x-ray. Ana iya yin allurar fenti a cikin jijiya ko haɗiye don taimakawa gabobin ko kyallen takarda su fito fili karara. Wannan hanya ana kiranta yanayin ƙididdigar lissafi, ƙirar kwamfuta, ko ƙirar ƙwaƙwalwar ajiyar kwamfuta.

• PET-CT scan: Hanya ce wacce ta haɗu da hotuna daga sifar fitar sinadarin positron (PET) da kuma hoton da aka ƙididdiga (CT). Ana yin sikanin PET da CT a lokaci guda tare da inji ɗaya. Scididdigar hotunan yana ba da cikakkun hotuna na wurare a cikin jiki fiye da kowane hoto da yake bayarwa da kansa. Binciken PET hanya ce don nemo ƙwayoyin cuta masu illa a jiki. An sanya ƙwayar glucose mai ƙarancin rediyo (sukari) a cikin jijiya. Na'urar daukar hoton PET tana juyawa a jiki kuma tana yin hoto inda ake amfani da glucose a jiki. Kwayoyin cuta masu illa suna nuna haske a hoton saboda suna aiki kuma suna ɗaukar glucose fiye da ƙwayoyin al'ada.

• Nazarin ilimin sunadarai na jini: Hanya ce wacce ake bincikar samfurin jini don auna adadin wasu abubuwa da aka saki a cikin jini ta gabobi da kayan aiki a jiki. Adadin abu na yau da kullun (mafi girma ko ƙasa da al'ada) na iya zama alamar cuta.

• Gwajin Antiglobulin: Gwaji ne wanda ake duban samfurin jini a ƙarƙashin microscope don gano ko akwai wasu ƙwayoyin cuta a saman jan jini ko platelets. Waɗannan ƙwayoyin cuta na iya amsawa tare da lalata jan ƙwayoyin jini da platelets. Wannan gwajin kuma ana kiransa gwajin Coombs.

Ana amfani da matakai masu zuwa don cutar sankarar bargo ta lymphocytic:

Mataki na 0

A cikin mataki na 0 na cutar sankarar bargo na lymphocytic, akwai ƙwayoyin lymphocytes da yawa a cikin jini, amma babu wasu alamu ko alamomin cutar sankarar bargo. Mataki na 0 na cutar sankarar bargo wanda ke da saurin kuzari ba shi da ƙarfi (yana saurin girma).

Mataki Na

A cikin matakin I lymphocytic leukemia na yau da kullun, akwai ƙwayoyin lymphocytes da yawa a cikin jini kuma ƙwayoyin lymph sun fi girma fiye da al'ada.

Mataki na II

A mataki na II na cutar sankarar bargo na lymphocytic, akwai ƙwayoyin lymphocytes da yawa a cikin jini, hanta ko saifa sun fi girma fiye da yadda ake yi, kuma ƙwayoyin lymph ɗin na iya zama sun fi girma fiye da yadda suke.

Mataki na III

A mataki na III na cutar sankarar bargo na lymphocytic, akwai ƙwayoyin lymphocytes da yawa a cikin jini kuma akwai ƙananan ƙwayoyin jini. Lymph nodes, hanta, ko baƙin ciki na iya zama girma fiye da yadda aka saba.

Mataki na IV

A mataki na huɗu na cutar sankarar bargo na lymphocytic, akwai ƙwayoyin lymphocytes da yawa a cikin jini da kuma ƙaramin platelet. Lymph nodes, hanta, ko baƙin ciki na iya zama girma fiye da yadda yake kuma akwai ƙananan ƙwayoyin jini.

Maimaitawa ko Rashin ractwayar cutar sankarar bargo

Maganin cutar sankarar bargo na yau da kullum shine cutar daji da ta sake dawowa (dawowa), galibi bayan wani lokaci wanda ba a iya gano kansar ba. Kwayar cutar sankarar bargo mai saurin kamuwa da cutar kansa ita ce kansar da ba ta samun sauki tare da magani.

Bayanin Zaɓin Jiyya

MAGANAN MAGANA

• Akwai nau'ikan magani daban-daban ga marasa lafiya da cutar sankarar bargo ta lymphocytic.

• Ana amfani da nau'i biyar na daidaitaccen magani:

• Jiran jira

• Radiation far
• Chemotherapy

• Tiyata

• Ciwon da aka yi niyya

• Ana gwada sababbin nau'ikan magani a gwajin asibiti.

• Chemotherapy tare da dasawa da kwayar halitta

• Immunotherapy

• Jiyya don cutar sankarar bargo ta lymphocytic na yau da kullun na iya haifar da illa.

• Marasa lafiya na iya son yin tunani game da shiga cikin gwaji na asibiti.

• Marasa lafiya na iya shiga gwajin asibiti kafin, lokacin, ko bayan fara maganin cutar kansa.

• Ana iya buƙatar gwaje-gwaje na gaba.

Akwai nau'ikan magani daban-daban ga marasa lafiya da cutar sankarar bargo ta lymphocytic.

Akwai nau'ikan magani daban-daban ga marasa lafiya masu fama da cutar sankarar bargo ta lymphocytic. Wasu jiyya suna daidaito (magani da ake amfani dashi yanzu), kuma wasu ana gwada su a gwajin asibiti. Gwajin gwajin magani shine binciken bincike wanda aka tsara don taimakawa inganta ingantattun jiyya na yanzu ko samun bayanai game da sababbin jiyya ga marasa lafiya da ciwon daji. Lokacin da gwaji na asibiti ya nuna cewa sabon magani ya fi magani na yau da kullun, sabon magani na iya zama daidaitaccen magani. Marasa lafiya na iya son yin tunani game da shiga cikin gwaji na asibiti. Wasu gwaji na asibiti ana buɗe su ne kawai ga marasa lafiyar da basu fara magani ba.

Ana amfani da nau'i biyar na daidaitaccen magani:

Jiran jira

Tsayawa a hankali yana lura da yanayin mai haƙuri ba tare da ba da wani magani ba har sai alamu ko alamu sun bayyana ko canzawa. Wannan kuma ana kiransa lura. A wannan lokacin, ana magance matsalolin da cutar ta haifar, kamar kamuwa da cuta.

Radiation Radiation Radiation shine maganin ciwon daji wanda ke amfani da hasken rana mai ƙarfi ko wasu nau'ikan haskoki don kashe ƙwayoyin kansa ko hana su girma. Magungunan radiation na waje yana amfani da wata na'ura a wajen jiki don aika jujjuyawar zuwa jikin jiki da cutar kansa.

Ana amfani da maganin radiation na waje don magance cutar sankarar bargo ta lymphocytic.

Chemotherapy

Chemotherapy magani ne na cutar kansa wanda ke amfani da magunguna don dakatar da haɓakar ƙwayoyin kansa, ko dai ta hanyar kashe ƙwayoyin ko ta hana su rarraba. Lokacin da ake shan chemotherapy ta baki ko allura a cikin jijiya ko tsoka, magungunan suna shiga cikin jini kuma zasu iya kaiwa ga kwayoyin cutar kansa a cikin jiki duka (systemotherapy chemotherapy). Lokacin da aka sanya chemotherapy kai tsaye zuwa cikin ruwa mai ruɓaɓɓen ciki, gaɓoɓi, ko rami na jiki kamar ciki, ko magungunan sun fi shafar ƙwayoyin cutar kansa a waɗancan yankuna (yankin yanki) Hanyar da ake ba da cutar sankara ta dogara da nau'in da matakin cutar kansa.

Dubi Magungunan da aka Amince don Ciwon Cutar Liman na Kullum don ƙarin bayani.

Tiyata

Splenectomy shine tiyata don cire saifa.

Ciwon da aka yi niyya

Targeted therapy wani nau'in magani ne wanda yake amfani da magunguna ko wasu abubuwa don ganowa da afkawa takamaiman ƙwayoyin cutar kansa ba tare da cutar ƙwayoyin halitta ba. Magungunan rigakafi na monoclonal, maganin hana cin hanci na tyrosine kinase, da kuma maganin hana yaduwar BCL2 sune nau'ikan maganin da aka yi niyya don maganin cutar sankarar bargo ta lymphocytic.

Tyrosine kinase inhibitor far shine maganin ciwon daji wanda ke toshe siginonin da ake buƙata don ciwace-ciwacen girma.

BCL2 maganin hanawa magani ne na ciwon daji wanda ke toshe furotin da ake kira BCL2. BCL2 mai hana hanawa na iya kashe ƙwayoyin kansa kuma yana iya sa su zama masu saurin kula da sauran magungunan maganin sankarau.

Dubi Magungunan da aka Amince don Ciwon Cutar Liman na Kullum don ƙarin bayani.

Ana gwada sababbin nau'ikan magani a gwajin asibiti.

Wannan ɓangaren taƙaitaccen bayani yana bayanin jiyya waɗanda ake nazarin su a gwajin asibiti. Yana iya ba ambaci kowane sabon magani ana nazarin. Ana samun bayani game da gwaji na asibiti daga gidan yanar gizon NCI.

Chemotherapy tare da dasawa da kwayar halitta

Chemotherapy tare da dasawar kwayar halitta hanya ce ta ba da cutar sankara da maye gurbin ƙwayoyin halitta masu kama jini da cutar kansa ta lalata. Ana cire ƙwayoyin sari (ƙwayoyin jinin da basu balaga ba) daga cikin jinin ko ƙashin ƙashin mara lafiya ko mai bayarwa kuma ana daskarar dasu ana adana su. Bayan an kammala maganin, an narke ƙwayoyin ƙwayoyin da aka adana kuma a mayar da su ga mai haƙuri ta hanyar jiko. Waɗannan ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin magungunan za a ɗibar

Immunotherapy

Immunotherapy magani ne wanda ke amfani da garkuwar jikin mara lafiya don yaƙar kansa. Abubuwan da jiki ya yi ko aka yi a dakin gwaje-gwaje ana amfani da su don haɓaka, kai tsaye, ko maido da kariya ta jiki daga cutar kansa. Wannan nau'in maganin cutar kansa ana kiransa biotherapy ko biologic therapy.

CAR T-cell therapy wani nau'i ne na rigakafi wanda ke canza ƙwayoyin T mai haƙuri (wani nau'in kwayar garkuwar jiki) don haka zasu afkawa wasu sunadarai a saman ƙwayoyin kansa. Ana ɗaukar ƙwayoyin T daga mai haƙuri kuma an ƙara masu karɓa na musamman zuwa saman su a cikin dakin gwaje-gwaje. Sel ɗin da aka canza ana kiran su ƙwayoyin chimeric antigen receptor (CAR) T. Kwayoyin CAR T suna girma a cikin dakin gwaje-gwaje kuma ana ba mai haƙuri ta hanyar jiko. Kwayoyin CAR T suna ninka cikin jinin mai haƙuri kuma suna kai wa ƙwayoyin kansa hari. Ana nazarin C-T-cell far a cikin maganin cutar sankarar bargo ta lymphocytic.

CAR T-cell far. Wani nau'in magani wanda ake canza ƙwayoyin T mai haƙuri (wani nau'in ƙwayoyin cuta na rigakafi) a cikin dakin gwaje-gwaje don haka zasu haɗu da ƙwayoyin kansa kuma su kashe su. Jini daga wata jijiya a hannun mara lafiyan yana gudana ta wani bututu zuwa na’urar apheresis (ba a nuna ba), wanda ke cire fararen ƙwayoyin jinin, gami da ƙwayoyin T, sa’annan ya mai da sauran jinin ga mai haƙuri. Bayan haka, an shigar da kwayar halitta ga mai karba na musamman da ake kira mai karbar sinadarin antim na chimeric (CAR) a cikin kwayoyin T a cikin dakin binciken. Miliyoyin ƙwayoyin CAR T suna girma a cikin dakin gwaje-gwaje sannan kuma a ba wa mai haƙuri ta hanyar jiko. Kwayoyin CAR T suna iya ɗaure kan antigen akan ƙwayoyin kansa kuma su kashe su.

Jiyya don cutar sankarar bargo ta lymphocytic na yau da kullun na iya haifar da illa.

Don bayani game da illolin da cutar ta kansar ta haifar, duba shafin mu na Side Side.

Marasa lafiya na iya son yin tunani game da shiga cikin gwaji na asibiti.

Ga wasu marasa lafiya, shiga cikin gwaji na asibiti na iya zama mafi kyawun zaɓin magani. Gwajin gwaji wani bangare ne na aikin binciken cutar kansa. Ana yin gwaje-gwajen asibiti don gano ko sabbin maganin cutar daji suna da lafiya da tasiri ko kuma sun fi magani na yau da kullun.

Yawancin yau da kullun na yau da kullun don cutar kansa sun dogara ne akan gwajin asibiti na farko. Marasa lafiya da ke cikin gwaji na asibiti na iya karɓar daidaitaccen magani ko kuma su kasance cikin farkon waɗanda za su karɓi sabon magani.

Marasa lafiya da ke shiga cikin gwaji na asibiti suma suna taimakawa inganta hanyar da za a bi da kansar a nan gaba. Koda lokacin gwajin asibiti bai haifar da sababbin magunguna ba, sau da yawa sukan amsa mahimman tambayoyi kuma suna taimakawa ci gaba da bincike gaba.

Marasa lafiya na iya shiga gwajin asibiti kafin, lokacin, ko bayan fara maganin cutar kansa.

Wasu gwaji na asibiti kawai sun haɗa da marasa lafiya waɗanda ba su sami magani ba tukuna. Sauran gwaje-gwajen suna gwada jiyya ga marasa lafiya waɗanda cutar kansa ba ta samu sauki ba. Hakanan akwai gwaji na asibiti da ke gwada sabbin hanyoyin dakatar da cutar kansa daga sake dawowa (dawowa) ko rage tasirin maganin kansar.

Gwajin gwaji na gudana a sassa da yawa na ƙasar. Bayani game da gwajin asibiti wanda NCI ke tallafawa ana iya samun shi akan shafin binciken gwaji na NCI. Ana iya samun gwajin gwaji na asibiti wanda wasu kungiyoyi ke tallafawa akan gidan yanar gizon ClinicalTrials.gov.

Ana iya buƙatar gwaje-gwaje na gaba.

Za a iya maimaita wasu gwaje-gwajen da aka yi don gano cutar kansa ko don gano matakin cutar kansa. Za a maimaita wasu gwaje-gwaje don ganin yadda magani ke aiki. Shawarwari game da ci gaba, canji, ko dakatar da magani na iya dogara ne da sakamakon waɗannan gwaje-gwajen.

Wasu daga cikin gwaje-gwajen za a ci gaba da yi daga lokaci zuwa lokaci bayan an gama jiyya. Sakamakon waɗannan gwaje-gwajen na iya nuna idan yanayin ku ya canza ko kuma idan kansar ta sake dawowa (dawo). Wadannan gwaje-gwajen wasu lokuta ana kiran su gwaje-gwaje na gaba ko dubawa.

Zaɓuɓɓukan Jiyya ta Mataki

A Wannan Sashin

• Mataki 0 ​​Na kullum Lymphocytic Leukemia

• Stage I, Stage II, Stage III, da Stage IV Chronic Lymphocytic Leukemia

Don bayani game da jiyya da aka jera a ƙasa, duba sashin Kula da Zaɓin Jiyya.

Mataki 0 ​​Na kullum Lymphocytic Leukemia

Jiyya na mataki 0 ​​na kullum lymphocytic cutar sankarar bargo yawanci kallo-jiran.

Yi amfani da binciken bincikenmu na asibiti don nemo NCI na goyan bayan gwajin asibiti wanda ke karɓar marasa lafiya. Kuna iya bincika gwaji dangane da nau'in ciwon daji, shekarun mai haƙuri, da kuma inda ake yin gwajin. Ana samun cikakken bayani game da gwaji na asibiti.

Stage I, Stage II, Stage III, da Stage IV Chronic Lymphocytic Leukemia

Jiyya na mataki na I, mataki na II, mataki na III, da mataki na huɗu na cutar sankarar bargo na lymphocytic na iya haɗa da masu zuwa:

• Jira a hankali lokacin da akwai 'yan kaɗan ko babu alamu ko alamu.

• Therapyaddamar da niyya tare da antibody na monoclonal, mai hana cin hanci da rashawa tyrosine, ko mai hanawa na BCL2.

• Chemotherapy tare da 1 ko fiye da kwayoyi, tare da ko ba tare da steroid ko maganin antibody monoclonal ba.

• Radiationananan ƙwayar ƙwayar ƙwayar cuta ta waje zuwa sassan jiki inda aka sami ciwon daji, kamar ƙwayoyin cuta ko ƙwayoyin lymph.

• Gwajin gwaji na ilimin kimiya da ilimin ilimin halittu tare da dasawar kwayar halitta.

• Gwajin gwaji na sabon magani.

Yi amfani da binciken bincikenmu na asibiti don nemo NCI na goyan bayan gwajin asibiti wanda ke karɓar marasa lafiya. Kuna iya bincika gwaji dangane da nau'in ciwon daji, shekarun mai haƙuri, da kuma inda ake yin gwajin. Ana samun cikakken bayani game da gwaji na asibiti.

Zaɓuɓɓukan Jiyya don Maimaitawa ko Maɗaukaki Lymphocytic

Ciwon sankarar jini

Jiyya na maimaitawa ko ƙin cutar sankarar ƙwayoyin cuta na yau da kullun na iya haɗawa da ɗayan zaɓuɓɓukan maganin da aka bayyana a sama ko yin rajista a cikin gwajin asibiti na sabon magani. Dubi Stage I, Stage II, Stage III, da Stage IV Chronic Lymphocytic Leukemia sashe don ƙarin bayani.

Yi amfani da binciken bincikenmu na asibiti don nemo NCI na goyan bayan gwajin asibiti wanda ke karɓar marasa lafiya. Kuna iya bincika gwaji dangane da nau'in ciwon daji, shekarun mai haƙuri, da kuma inda ake yin gwajin. Ana samun cikakken bayani game da gwaji na asibiti.

Don Morearin Koyo game da Ciwon Cutar Sanyi na Ciwon Mara

Don ƙarin bayani daga Cibiyar Cancer ta cerasa game da cutar sankarar bargo ta lymphocytic, duba abubuwa masu zuwa:

• Shafin Farko na cutar sankarar bargo

• An Amince da Magungunan ƙwayoyin cuta na cutar sankarar bargo

• Magungunan Ciwon Cutar da Aka Yi niyya

• Immunotherapy don Kula da Ciwon daji

Don cikakkun bayanai game da cutar kansa da sauran albarkatu daga Cibiyar Cancer ta Kasa, duba mai zuwa:

• Game da Ciwon daji

• Tsayawa

• Chemotherapy da ku: Tallafi ga Mutanen da ke Ciwon daji

• Radiation Far da Kai: Taimako ga Mutane Tare da Ciwon daji

• Yin fama da Ciwon daji

• Tambayoyi don Tambayar Doctor game da Ciwon daji

• Don Tsira da Kulawa