Nau'o'in / cutar sankarar bargo / haƙuri / yaro-aml-treatment-pdq

Yarinyar Ciwon Cutar Myeloid Mai Ciwo / Sauran Maganin Rashin Lafiyar Myeloid (®) –Paent Version

Janar Bayani Game da Matsalar Ciwon Cutar Myeloid na Childhoodananan Yara da Sauran Matsalar Myeloid

MAGANAN MAGANA

• Yarinya mai saurin cutar sankarar bargo (AML) wani nau'in cutar kansa ne wanda ƙashin ƙashi yake haifar da adadi mai yawa na ƙwayoyin jini.

• Cutar sankarar jini da sauran cututtukan jini da ƙashi na iya shafar jajayen ƙwayoyin jini, da fararen ƙwayoyin jini, da platelets.

• Sauran cututtukan myeloid na iya shafar jini da ɓacin kashi.

• Myelopoiesis na yau da kullun (TAM)

• M cutar sankarar bargo (APL)

• Yarinyar cutar sankarar bargo (JMML)

• Cutar sankarar jini na yau da kullum (CML)

• Ciwon mahaifa (MDS)

• AML ko MDS na iya faruwa bayan jiyya tare da wasu magungunan ƙwayoyi da / ko radiation.

• Dalilan haɗarin yarin AML, APL, JMML, CML, da MDS sun yi kama.

• Alamomi da alamomin yarinta AML, APL, JMML, CML, ko MDS sun haɗa da zazzaɓi, jin kasala, da sauƙin zubar jini ko rauni.

• Ana amfani da gwaje-gwajen da ke bincikar jini da ƙashi a gano (gano) da kuma tantance ƙuruciyarsu AML, TAM, APL, JMML, CML, da MDS.

• Wasu dalilai suna tasiri hangen nesa (damar dawowa) da zaɓuɓɓukan magani.

Yarinya mai saurin cutar sankarar bargo (AML) wani nau'in cutar kansa ne wanda ƙashin ƙashi yake haifar da adadi mai yawa na ƙwayoyin jini.

Yarinya mai saurin cutar sankarar bargo (AML) ciwon daji ne na jini da kashin kashi. AML kuma ana kiranta da cutar sankarar myelogenous mukelchi, mukeloblastic leukemia, m granulocytic leukemia, da kuma m nonlymphocytic leukemia. Cutar sankara da ke saurin kamuwa da cuta galibi ta kan yi muni idan ba a kula da su ba. Cutar cutar kanjamau da ke ci gaba da lalacewa koyaushe tana daɗa faruwa a hankali.

Anatomy na kashi. Kashin ya kunshi karamin kashi, kashin baya, da kashin baya. Karamin kashi yana yin layin waje na ƙashi. Ana samun kashin Spongy galibi a ƙarshen ƙasusuwa kuma yana ɗauke da jajaja. Ana samun kasusuwan kasusuwa a tsakiyar mafi yawan kasusuwa kuma yana da jijiyoyi da yawa. Akwai kashin kashi biyu: ja da rawaya. Jan kashin jini ya ƙunshi ƙwayoyin jini wanda zai iya zama jajayen ƙwayoyin jini, fararen ƙwayoyin jini, ko platelets. An sanya kasusuwan rawaya mafi yawan mai.

Cutar sankarar jini da sauran cututtukan jini da ƙashi na iya shafar jajayen ƙwayoyin jini, da fararen ƙwayoyin jini, da platelets.

A yadda aka saba, ƙashin ƙasusuwa yana sa ƙwayoyin jini na jini (ƙwayoyin da ba su balaga ba) waɗanda suka zama ƙwararrun ƙwayoyin jini a kan lokaci. Stemwayar ƙwayar ƙwayar jini na iya zama ƙwayar ƙwayar myeloid ko ƙwayar ƙwayar ƙwayar lymphoid. Kwayar kwayar lymphoid ta zama farin jini.

Kwayar kara kuzari ta myeloid ta zama ɗayan nau'ikan nau'ikan ƙwayoyin jini uku masu girma:

• Jajayen jini wadanda suke daukar iskar oxygen da sauran abubuwa zuwa dukkan kyallen takarda.

• Farin jini wanda ke yakar kamuwa da cuta.

• Platelets wadanda suke samar da daskararren jini dan tsaida zubar jini.

Ci gaban kwayar jini. Kwayar sel ta jini tana wucewa ta matakai da yawa don zama jajayen jini, platelet, ko kuma farin jini.

A cikin AML, ƙwayoyin ƙwayoyin myeloid yawanci suna zama nau'in kwayar jinin fari mara girma wanda ake kira myeloblasts (ko fashewar myeloid) Myeloblasts, ko ƙwayoyin cutar sankarar bargo, a cikin AML baƙon abu ne kuma ba su zama lafiyayyun ƙwayoyin jini. Kwayoyin cutar sankarar bargo na iya haɗuwa a cikin jini da ɓarke ​​don haka akwai ƙarancin wuri don lafiyayyun ƙwayoyin jini, da jajayen ƙwayoyin jini, da platelets. Lokacin da wannan ya faru, kamuwa da cuta, ƙarancin jini, ko saurin zubar jini na iya faruwa.

Kwayoyin cutar sankarar bargo na iya yadawa a wajen jini zuwa sauran sassan jiki, gami da tsarin jijiyoyin tsakiya (kwakwalwa da lakar kashin baya), fata, da gumis. Wasu lokuta kwayoyin cutar sankarar bargo suna samar da ƙwayar cuta mai ƙarfi wanda ake kira sarcoma na granulocytic ko chloroma.

Sauran cututtukan myeloid na iya shafar jini da ɓacin kashi.

Myelopoiesis na yau da kullun (TAM)

TAM cuta ce ta ɓacin kashi wanda zai iya haɓaka cikin jarirai waɗanda ke da cutar Down Down. Yawanci yakan tafi da kansa ne tsakanin watanni 3 na farkon rayuwa. Yaran da ke da TAM suna da damar haɓaka AML kafin shekara 3. Ana kiran TAM kuma mai rikitarwa mai rikitarwa mai rikitarwa ko cutar sankarar bargo.

M cutar sankarar bargo (APL)

APL ƙaramin nau'in AML ne. A cikin APL, wasu kwayoyin akan 15 masu canza chromosome tare da wasu kwayoyin akan chromosome 17 kuma an samar da wata kwayar halitta wacce ba a saba gani ba da ake kira PML-RARA. Kwayar PML-RARA tana aika sako wanda yake dakatar da masu yada kwayar halitta (wani nau'in farin jini) daga balaga. Abubuwan da ke yaduwa (kwayoyin cutar sankarar bargo) na iya haɗuwa a cikin jini da ɓarke ​​don haka akwai ƙarancin wuri don lafiyayyun ƙwayoyin jini, da jajayen ƙwayoyin jini, da platelets. Matsaloli tare da tsananin zub da jini da kuma daskarewar jini na iya faruwa. Wannan babbar matsalar lafiya ce wacce ke buƙatar magani da wuri-wuri.

Yarinyar cutar sankarar bargo (JMML)

JMML cutar sankara ce wacce ba kasafai ake samunta ba a yara wanda ke kusan shekaru 2 kuma ya fi faruwa ga yara maza. A cikin JMML, ƙwayoyin jini masu yawa da yawa suna zama myelocytes da monocytes (nau'ikan ƙwayoyin jini guda biyu). Wasu daga cikin wadannan kwayoyin myeloid din din din din din din din din din din din din din ba zai zama ya zama farin jini ba. Wadannan kwayoyin halitta wadanda basu balaga ba, wadanda ake kira blasts, basa iya yin aikin da suka saba. Da shigewar lokaci, myelocytes, monocytes, da kuma hargitsi sun fitar da jajayen ƙwayoyin jini da platelet a cikin ɓarin kashi. Lokacin da wannan ya faru, kamuwa da cuta, ƙarancin jini, ko saurin zubar jini na iya faruwa.

Cutar sankarar jini na yau da kullum (CML)

CML yakan fara ne a farkon ƙwayar myeloid lokacin da wani canjin yanayi ya auku. Wani sashe na kwayar halitta, wanda ya hada da kwayar halittar ABL, akan chromosome 9 ya canza wuri tare da wani bangare na kwayoyin halitta akan chromosome 22, wanda ke da kwayar BCR. Wannan yana haifar da gajeren chromosome 22 (wanda ake kira chromosome na Philadelphia) da kuma chromosome mai tsayi sosai 9. An samar da kwayar halittar BCR-ABL mara kyau akan chromosome kinase. Tyrosine kinase yana sa a yi farin ƙwayoyin jini da yawa (leukemia cells) a cikin ɓacin kashi. Kwayoyin cutar sankarar bargo na iya haɗuwa a cikin jini da ɓarke ​​don haka akwai ƙarancin wuri don lafiyayyun ƙwayoyin jini, jajayen ƙwayoyin jini, da platelets. Lokacin da wannan ya faru, kamuwa da cuta, ƙarancin jini, ko saurin zubar jini na iya faruwa. CML yana da wuya a yara.

Philadelphia chromosome. Wani yanki na chromosome 9 da wani yanki na chromosome 22 sun watse kuma suna wuraren kasuwanci. An samo asalin BCR-ABL akan chromosome 22 inda yanki na chromosome 9 ya rataya. Canjin chromosome na 22 ana kiransa chromosome na Philadelphia.

Ciwon mahaifa (MDS)

MDS ba ta faruwa sau da yawa a cikin yara fiye da ta manya. A cikin MDS, bargon kasusuwa yana yin 'yan kaɗan da jajayen ƙwayoyin jini, fararen ƙwayoyin jini, da platelets. Wadannan kwayoyin jinin bazai yi girma ba su shiga cikin jini. Nau'in MDS ya dogara da nau'in ƙwayoyin jinin da abin ya shafa.

Maganin MDS ya dogara ne da ƙananan lambobin jan jini, fararen ƙwayoyin jini, ko platelets. Bayan lokaci, MDS na iya zama AML.

Wannan taƙaitaccen bayani game da AML, TAM, APL na yara, JMML, CML na yara, da MDS na yara. Dubi taƙaitaccen Jiyya game da cutar sankarar ƙwayar cuta ta yara game da yara game da maganin cutar sankarar bargo ta yara.

AML ko MDS na iya faruwa bayan jiyya tare da wasu magungunan ƙwayoyi da / ko radiation.

Maganin ciwon daji tare da wasu magungunan ƙwayoyin cuta da / ko raɗaɗɗen radiyo na iya haifar da AML (t-AML) mai alaƙa da magani ko MDS (t-MDS). Haɗarin waɗannan cututtukan myeloid da ke da alaƙa da farfadowa ya dogara da yawan adadin magungunan ƙwayoyi da aka yi amfani da su da kuma ƙwayar radiation da filin kulawa. Wasu marasa lafiya kuma suna da haɗarin gado don t-AML da t-MDS. Wadannan cututtukan da suka shafi farfadowa galibi suna faruwa ne tsakanin shekaru 7 bayan jiyya, amma ba safai a ga yara ba.

Dalilan haɗarin yarin AML, APL, JMML, CML, da MDS sun yi kama.

Duk wani abu da zai kara maka hadarin kamuwa da cuta to ana kiran sa mai hadari. Samun haɗari ba ya nufin cewa za ku kamu da cutar kansa; ba tare da haɗarin abubuwan haɗari ba yana nufin cewa ba zaku sami cutar kansa ba. Yi magana da likitan ɗanka idan kana tunanin ɗanka na cikin haɗari. Waɗannan da wasu abubuwan na iya ƙara haɗarin yarinta AML, APL, JMML, CML, da MDS:

• Samun ɗan'uwa ko 'yar'uwa, musamman ma tagwaye, tare da cutar sankarar bargo.

• Kasancewarsa Ba'amurke.

• Kasancewa da hayaki sigari ko giya kafin haihuwa.

• Samun tarihin mutum na cutar karancin jini.

• Samun tarihin mutum ko na iyali na MDS.

• Samun tarihin iyali na AML.

• Jiyya ta baya tare da chemotherapy ko radiation radiation.

• Kasancewa da farar iska ko kuma sunadarai irin su benzene.

• Samun wasu cututtukan cuta ko rikicewar gado, kamar:

• Ciwon rashin lafiya.

• Ruwan jini

• Fanconi anemia

• Neurofibromatosis nau'in 1.

• Ciwon Noonan.

• Ciwon Shwachman-Diamond.

• Ciwon Li-Fraumeni.

Alamomi da alamomin yarinta AML, APL, JMML, CML, ko MDS sun haɗa da zazzaɓi, jin kasala, da sauƙin zubar jini ko rauni.

Wadannan da sauran alamu da alamomin na iya faruwa ne ta hanyar yarinta AML, APL, JMML, CML, ko MDS ko kuma ta wasu yanayi. Duba tare da likita idan ɗanka yana da ɗayan masu zuwa:

• Zazzabi tare da ko ba tare da kamuwa da cuta ba.

• Zufar dare.

• Rashin numfashi.

• Rashin rauni ko jin kasala.

• Aramar rauni ko zubar jini.

• Petechiae (lebur, tabo daidai a karkashin fata sanadiyyar zubar jini).

• Jin zafi a cikin ƙasusuwa ko haɗin gwiwa.

• Jin zafi ko jin cikawa ƙasa da haƙarƙarin.

• Lumanƙara mara zafi a cikin wuya, ƙarancin ciki, ciki, makwancin gwaiwa, ko wasu sassan jiki. A lokacin yarinta AML, waɗannan kumburin, ana kiransu cutar sankarar bargo

• cutis, na iya zama shuɗi ko shunayya.

• Kumburai marasa jin zafi waɗanda wasu lokuta ke kusa da idanu. Wadannan kumburin, ana kiran su chloromas, wani lokacin ana ganin su a lokacin yarinta AML kuma suna iya zama shuɗi-shuɗi.

• Fuskar kamar eczema.

Alamomi da alamomin TAM na iya haɗawa da waɗannan masu zuwa:

• Kumburi ko'ina a jiki.

• Rashin numfashi.

• Rashin numfashi.

• Rashin rauni ko jin kasala.

• Zuban jini dayawa, koda daga karamar yanka.

• Petechiae (lebur, tabo daidai a karkashin fata sanadiyyar zubar jini).

• Jin zafi a ƙasa da haƙarƙarin.

• Rushewar fata.

• Jaundice (raunin fata da fararen idanu).

• Ciwon kai, ganin matsala, da rikicewa.

Wani lokaci TAM baya haifar da wata alama ko kaɗan kuma ana bincika shi bayan gwajin jini na yau da kullun.

Ana amfani da gwaje-gwajen da ke bincikar jini da ƙashi a gano (gano) da kuma tantance ƙuruciyarsu AML, TAM, APL, JMML, CML, da MDS. Za a iya amfani da waɗannan gwaje-gwajen da hanyoyin:

• Jarabawa ta jiki da tarihi: Jarabawa ce ta jiki don bincika alamomin lafiya gaba ɗaya, gami da bincika alamun cuta, kamar kumburi ko wani abu da kamar baƙon abu. Za a kuma ɗauki tarihin al'adun lafiyar marasa lafiya da cututtukan da suka gabata da magunguna.
• Cikakken ƙidayar jini (CBC) tare da banbanci: Hanyar da za'a zana samfurin jini kuma a bincika ta mai zuwa:

• Yawan jajayen kwayoyin jini da platelets.

• Adadi da nau'in farin jini.

• Adadin haemoglobin (furotin da ke ɗauke da iskar oxygen) a cikin ƙwayoyin jinin jini.

• Yankin samfurin jini ya kunshi jajayen ƙwayoyin jini.

Kammala lissafin jini (CBC). Ana tattara jini ta hanyar sanya allura a cikin jijiya da kuma barin jini ya kwarara cikin bututu. Ana aika samfurin jini zuwa dakin gwaje-gwaje kuma ana kidaya ƙwayoyin jinin jini, fararen ƙwayoyin jini, da kuma platelets. Ana amfani da CBC don gwadawa, gano asali, da kuma lura da yanayi daban-daban.

Nazarin ilimin sunadarai na jini: Hanya ce wacce ake bincikar samfurin jini don auna adadin wasu abubuwa da aka saki a cikin jini ta gabobi da kayan aiki a jiki. Adadin abu na yau da kullun (mafi girma ko ƙasa da al'ada) na iya zama alamar cuta.

• Kirjin x-ray: X-ray na gabobin da kasusuwa a cikin kirji. X-ray wani irin katako ne na katako wanda zai iya ratsa jiki zuwa fim, yana yin hoton wurare a cikin jiki.

• Biopsy: Cirewar ƙwayoyin halitta ko kyallen takarda don a iya kallon su ta hanyar microscope ta hanyar masanin ilimin ɗan adam don bincika alamun kansar. Biopsies da za'a iya yi sun haɗa da masu zuwa:

• Burin kasusuwan kasusuwa da kuma biopsy: Cire kasusuwan kasusuwa, jini, da karamin guntun kashi ta hanyar sanya allura mara kyau a cikin kashin hanji ko kashin mama.

Burin kasusuwa da biopsy. Bayan an lasafta wani karamin yanki na fata, sai a saka allurar kasusuwa ta kashin a cikin kashin cincin yaron. Ana cire samfurorin jini, kashi, da kashin nama don bincike a karkashin wani madubin likita.

• Tumor biopsy: Za'a iya yin biopsy na chloroma.

• Lymph node biopsy: Cire duka ko ɓangaren kumburin lymph.

• Immunophenotyping: Gwajin dakin gwaje-gwaje da ke amfani da kwayoyin cuta don gano kwayoyin cutar kansar dangane da nau'ikan antigens ko alamomi a saman sel. Ana amfani da wannan gwajin don taimakawa wajen gano takamaiman nau'ikan cutar sankarar bargo.

• Nazarin Cytogenetic: Gwajin dakin gwaje-gwaje wanda aka kirga chromosomes na kwayoyi a cikin samfurin jini ko jiji da kashi don bincika kowane canje-canje, kamar karye, ɓacewa, sake gyarawa, ko ƙarin ƙwanƙwanni. Canje-canje a cikin wasu chromosomes na iya zama alamar cutar kansa. Ana amfani da nazarin Cytogenetic don taimakawa gano cutar kansa, shirya magani, ko gano yadda magani ke aiki.

Gwajin da ke zuwa shine nau'in nazarin halittu:

• KIFI (haske a cikin yanayin haɗuwa): Gwajin gwaje-gwaje da ake amfani dashi don kallo da ƙididdigar kwayoyin halitta ko chromosomes a cikin ƙwayoyin halitta da kyallen takarda. Ana yin yanki na DNA da ke ɗauke da launuka masu kyalli a cikin dakin gwaje-gwaje kuma an ƙara su zuwa samfurin ƙwayoyin marasa lafiya ko kyallen takarda. Lokacin da wadannan sassan DNA din da aka rina suka hade da wasu kwayoyin halitta ko bangarorin chromosomes a cikin samfurin, suna haskakawa idan aka kalleshi a karkashin madubin hangen nesa. Ana amfani da gwajin FISH don taimakawa wajen gano kansar da kuma taimakawa shirya magani.

• Gwajin ƙwayoyin cuta: Gwajin gwaje-gwaje don bincika wasu ƙwayoyin halitta, sunadarai, ko wasu ƙwayoyin cuta a cikin samfurin jini ko ɓarke. Hakanan gwajin kwayoyin yana bincika wasu canje-canje a cikin kwayar halitta ko ƙirar chromosome wanda na iya haifar ko shafar damar haɓaka AML. Ana iya amfani da gwajin kwayar don taimakawa shirin shirya magani, gano yadda magani ke aiki, ko yin hangen nesa.

• Lumbar puncture: Hanya ce da ake amfani da ita don tattara samfurin ruwan ciki (CSF) daga sashin kashin baya. Ana yin wannan ta sanya allura tsakanin ƙasusuwa biyu a cikin kashin baya da kuma cikin CSF a kewayen ƙashin baya da cire samfurin ruwan. An bincika samfurin CSF a ƙarƙashin microscope don alamun da ke nuna cewa cutar sankarar bargo ta bazu zuwa kwakwalwa da laka. Wannan hanyar ana kiranta LP ko taɓar kashin baya.

Lumbar huda Mai haƙuri yana kwance a cikin lankwasawa akan tebur. Bayan an kidaya wani karamin yanki a kasan baya, sai a saka allura ta kashin baya (dogon, siririn sirara) a cikin sashin kasan kashin kashin baya don cire ruwan ciki na kwakwalwa (CSF, wanda aka nuna a shudi). Ana iya aika ruwan zuwa dakin gwaje-gwaje don gwaji.

Wasu dalilai suna tasiri hangen nesa (damar dawowa) da zaɓuɓɓukan magani.

Hangen nesa (damar dawowa) da zaɓuɓɓukan magani don AML na ƙuruciya sun dogara da masu zuwa:

• Shekarun yaro lokacin da aka gano cutar kansa.

• Tsere ko ƙabilar yaro.

• Ko yaron yayi nauyi sosai.

• Adadin fararen ƙwayoyin jini a cikin jini a ganewar asali.

• Ko AML ta faru ne bayan maganin ciwon daji na baya.

• Karamin nau'in AML.

• Ko akwai wasu canje-canje na chromosome ko canjin halitta a cikin kwayoyin cutar sankarar bargo.

• Ko yaron yana da cutar rashin lafiya. Yawancin yara masu cutar AML da Down suna iya warkar da cutar sankarar bargo.

• Ko cutar sankarar bargo tana cikin tsarin jijiyoyi na tsakiya (kwakwalwa da laka).

• Yaya saurin cutar sankarar bargo ta amsa magani.

• Ko AML an gano ta sabuwa (ba a kula da ita ba) ko kuma ta sake dawowa bayan jiyya.

• Tsawon lokaci tun lokacin da magani ya ƙare, don AML da ya sake dawowa.

Hannun hangen nesa na APL na yara ya dogara da masu zuwa:

• Adadin fararen ƙwayoyin jini a cikin jini a ganewar asali.

• Ko akwai wasu canje-canje na chromosome ko canjin halitta a cikin kwayoyin cutar sankarar bargo.

• Ko APL sabuwa ce aka gano (ba a kula da ita ba) ko kuma ta dawo bayan magani.

Hanyoyin hangen nesa da zaɓuɓɓukan magani don JMML sun dogara da masu zuwa:

• Shekarun yaro lokacin da aka gano cutar kansa.

• Nau'in kwayar halitta da abin ya shafa da yawan kwayoyin halittar da ke da canje-canje.

• Monocytes nawa (nau'in farin jini) suke a cikin jini.

• Yaya yawan haemoglobin yake a cikin jini.

• Ko JMML sabon cuta ne (ba a kula da shi ba) ko kuma ya sake dawowa bayan jiyya.

Hanyoyin hangen nesa da zaɓuɓɓukan magani don ƙananan yara na CML sun dogara da masu zuwa:

• Yaya tsawon lokacin da aka gano haƙuri.

• Nawa kwayoyin fashewa da yawa suna cikin jini.

• Ko yaya kuma yadda cikakkun kwayoyin fashewar suka bace daga jini da kashin bayan kashin bayan farawar.

• Ko dai an sami sabon cutar ta CML (ba a kula da ita ba) ko kuma ta dawo bayan magani.

Hanyoyin hangen nesa da zaɓuɓɓukan magani na MDS sun dogara da masu zuwa:

• Ko MDS ya samo asali ne daga maganin ciwon daji na baya.

• Yaya ƙananan lambobin jan jini, farin ƙwayoyin jini, ko platelets suke.

• Ko dai MDS sabon bincike ne (ba a magance shi ba) ko kuma ya sake dawowa bayan jiyya.

Matakai na Matsalar Ciwon Cutar Myeloid Mai Girma da Sauran Cutar Myeloid

MAGANAN MAGANA

• Da zarar an gano ƙananan cutar sankarar bargo na yara (AML), ana yin gwaji don gano ko ciwon kansa ya bazu zuwa wasu sassan jiki.

• Babu wani tsarin tsayayyar tsari don yarinta AML, cutar sankarar bargo mai saurin yaduwar yara (APL), cutar sankarar myelomonocytic yara (JMML), cutar sankarar myelogenous na yara (CML), ko myelodysplastic syndromes (MDS).

• Yawan yarinta AML ya dawo bayan an yi masa magani.

Da zarar an gano ƙananan cutar sankarar bargo na yara (AML), ana yin gwaji don gano ko ciwon kansa ya bazu zuwa wasu sassan jiki.

Ana iya amfani da gwaje-gwaje da hanyoyin da ke tafe don sanin ko cutar sankarar bargo ta bazu daga jini zuwa sauran sassan jiki:

• Lumbar puncture: Hanya ce da ake amfani da ita don tattara samfurin ruwan ciki (CSF) daga sashin kashin baya. Ana yin wannan ta sanya allura tsakanin ƙasusuwa biyu a cikin kashin baya da kuma cikin CSF a kewayen ƙashin baya da cire samfurin ruwan. An bincika samfurin CSF a ƙarƙashin microscope don alamun da ke nuna cewa cutar sankarar bargo ta bazu zuwa kwakwalwa da laka. Wannan hanyar ana kiranta LP ko taɓar kashin baya.

• Kwayar halittar kwayar halittar mahaifar, kwayayen, ko fata: Cire kwayoyin halitta ko kyallen takarda daga kwayoyin halittar, kwayayen, ko fata don haka ana iya dubansu a karkashin wani madubin hangen nesa don bincika alamun kansar. Ana yin hakan ne kawai idan an sami wani abu mai ban mamaki game da kwayar halittar mace, ko kwan mace, ko fata yayin gwajin jiki.

Babu wani tsarin tsayayyar tsari don yarinta AML, cutar sankarar bargo mai saurin yaduwar yara (APL), cutar sankarar myelomonocytic yara (JMML), cutar sankarar myelogenous na yara (CML), ko myelodysplastic syndromes (MDS).

Yawancin lokaci ko yaduwar ciwon daji yawanci ana bayyana shi a matsayin matakai. Maimakon matakai, maganin yarinta AML, APL na yara, JMML, CML na yara, da MDS sun dogara ne akan ɗaya ko fiye da masu zuwa:

• Nau'in cuta ko nau'in AML.

• Ko cutar sankarar bargo ta yadu a wajen jini da kashin kashi.

• Ko cutar ta kasance sabon bincike, a cikin gafartawa, ko maimaitawa.

Sabon binciken yara AML

Sabon maganin yarinta AML ba a kula da shi sai don sauƙaƙe alamomi da alamomi kamar zazzaɓi, zubar jini, ko ciwo, kuma ana samun ɗayan masu zuwa:

• Fiye da kashi 20 cikin ɗari na ƙwayoyin halittar da ke cikin ɓarke-ɓarke ​​ne (ƙwayoyin cutar sankarar bargo).

ko

• Kasa da kashi 20 cikin dari na kwayoyin halittar da ke cikin kashin kasusuwa sune fashewa kuma akwai wani canji a cikin chromosome.

Yaran AML a cikin gafartawa

A lokacin yarinta AML cikin gafara, an magance cutar kuma ana samun waɗannan masu zuwa:

• Cikakken adadin jini kusan al'ada ne.

• Kasa da kashi 5% na kwayoyin halittar da ke cikin kashin kasusuwa sune fashewa (kwayoyin cutar sankarar bargo).

• Babu alamu ko alamun cutar sankarar bargo a cikin kwakwalwa, laka, ko sauran sassan jiki.

Yawan yarinta AML ya dawo bayan an yi masa magani.

A cikin ƙaramar yarinta ta AML, kansar na iya dawowa cikin jini da ƙashi ko a wasu sassan jiki, kamar su tsarin juyayi na tsakiya (kwakwalwa da laka).

A cikin ƙananan ƙarancin AML, ciwon daji ba ya amsa magani.

Bayanin Zaɓin Jiyya

MAGANAN MAGANA

• Akwai nau'ikan magani daban-daban na yara masu AML, TAM, APL, JMML, CML, da MDS.

• Isungiyar masu ba da lafiya sun shirya jiyya waɗanda ƙwararru ne wajen kula da cutar sankarar bargo na yara da sauran cututtukan jini.

• Jiyya don ƙananan cutar sankarar bargo na yara na iya haifar da illa.

• Maganin yarinta AML galibi yana da matakai biyu.

• Ana amfani da nau'ikan daidaitaccen magani guda bakwai don AML, TAM, APL na yara, JMML, yarin CML, da MDS.

• Chemotherapy

• Radiation far

• Dasawar dasa kara

• Ciwon da aka yi niyya

• Sauran maganin magani

• Jiran jira

• Taimakon tallafi

• Ana gwada sababbin nau'ikan magani a gwajin asibiti.

• Immunotherapy

• Marasa lafiya na iya son yin tunani game da shiga cikin gwaji na asibiti.

• Marasa lafiya na iya shiga gwajin asibiti kafin, lokacin, ko bayan fara maganin cutar kansa.

• Ana iya buƙatar gwaje-gwaje na gaba.

Akwai nau'ikan magani daban-daban na yara masu AML, TAM, APL, JMML, CML, da MDS.

Akwai nau'ikan magani iri daban-daban ga yara masu fama da cutar sankarar myeloid (AML), mai rikitarwa mai rikitarwa myelopoiesis (TAM), cutar sankarar bargo mai saurin yaduwa (APL), yara masu cutar myelomonocytic leukemia (JMML), na kullum myelogenous leukemia (CML), da myelodysplast syS . Wasu jiyya suna daidaito (magani da ake amfani dashi yanzu), kuma wasu ana gwada su a gwajin asibiti. Gwajin gwajin magani shine binciken bincike wanda aka tsara don taimakawa inganta ingantattun jiyya na yanzu ko samun bayanai kan sababbin jiyya ga marasa lafiya da ciwon daji. Lokacin da gwaji na asibiti ya nuna cewa sabon magani ya fi magani na yau da kullun, sabon magani na iya zama daidaitaccen magani.

Saboda AML da sauran cututtukan myeloid ba su da yawa a cikin yara, ya kamata a yi la'akari da shiga cikin gwajin asibiti. Wasu gwaji na asibiti ana buɗe su ne kawai ga marasa lafiyar da basu fara magani ba.

Isungiyar masu ba da lafiya sun shirya jiyya waɗanda ƙwararru ne wajen kula da cutar sankarar bargo na yara da sauran cututtukan jini.

Jiyya za ta kula da likitan ilimin likitan yara, likita wanda ya kware kan kula da yara masu cutar kansa. Masanin ilimin likitan yara yana aiki tare da wasu masu ba da kiwon lafiya waɗanda ƙwararru ne wajen kula da yara da cutar sankarar bargo kuma waɗanda suka kware a wasu fannonin magani. Wadannan na iya hada da kwararru masu zuwa:

• Likitan yara.

• Likitan cututtukan ciki.

• Masanin ilimin likita na ilimin likita.

• Likitan likitan yara.

• Radiation oncologist

• Neurologist.

• Neuropathologist.

• Neuroradiologist.

• Kwararren likitan yara.

• Ma'aikacin zamantakewa.

• Gwanayen gyarawa.

• Masanin ilimin psychologist.

Jiyya don ƙananan cutar sankarar bargo na yara na iya haifar da illa.

Don bayani game da illolin da ke farawa yayin magani don cutar kansa, duba shafin Gurbinmu.

Gwajin bin diddigi na da matukar mahimmanci. Hanyoyi masu illa daga maganin ciwon daji wanda zai fara bayan jiyya kuma ya ci gaba tsawon watanni ko shekaru ana kiransa sakamako na ƙarshe. Sakamakon sakamako na maganin kansa na iya haɗa da masu zuwa:

• Matsalolin jiki.

• Canje-canje a cikin yanayi, ji, tunani, ilmantarwa, ko ƙwaƙwalwar ajiya.

• Cancer na biyu (sababbin nau'ikan cutar kansa).

Wasu maganganun ƙarshen ana iya magance su ko sarrafa su. Yana da mahimmanci iyayen yara waɗanda aka yiwa magani don AML ko wasu cututtukan jini suyi magana da likitocin ɗansu game da illar da cutar kansar ke haifarwa ga ɗansu. (Dubi taƙaitaccen bayanin akan ƙarshen tasirin Jiyya don Ciwon Childhoodan yara don ƙarin bayani).

Maganin yarinta AML galibi yana da matakai biyu.

Kula da AML na ƙuruciya ana yin sa ne a cikin matakai:

• Induction far: Wannan shine farkon wajan magani. Burin shine a kashe kwayoyin cutar sankarar bargo a cikin jini da kashin kashi. Wannan ya sanya cutar sankarar bargo cikin gafara.

• Therapyarfafawa / ƙarfafa ƙarfi: Wannan shi ne kashi na biyu na magani. Yana farawa ne da zarar cutar sankarar jini ta kasance cikin gafara. Makasudin magani shine a kashe sauran ƙwayoyin cutar sankarar bargo waɗanda ke ɓoye kuma maiyuwa basa aiki amma zasu iya fara sakewa kuma haifar da sake dawowa.

Jiyya da ake kira tsarin juyayi na tsakiya (CNS) ana iya ba da maganin prophylaxis yayin shigar da magani. Saboda daidaitattun allurai na chemotherapy bazai isa ƙwayoyin cutar sankarar jini ba a cikin CNS (kwakwalwa da laka), ƙwayoyin cutar sankarar bargo na iya ɓoyewa a cikin CNS. Intrathecal chemotherapy na iya isa ƙwayoyin cutar sankarar jini a cikin CNS. An bayar dashi don kashe kwayoyin cutar sankarar bargo kuma rage damar cutar sankarar jini ta sake dawowa (dawo).

Ana amfani da nau'ikan daidaitaccen magani guda bakwai don AML, TAM, APL na yara, JMML, yarin CML, da MDS.

Chemotherapy

Chemotherapy magani ne na cutar kansa wanda ke amfani da magunguna don dakatar da haɓakar ƙwayoyin kansa, ko dai ta hanyar kashe ƙwayoyin ko ta hana su rarraba. Lokacin da ake shan chemotherapy ta baki ko allura a cikin jijiya ko tsoka, magungunan suna shiga cikin jini kuma zasu iya kaiwa ga kwayoyin cutar kansa a cikin jiki duka (systemotherapy chemotherapy). Lokacin da aka sanya chemotherapy kai tsaye zuwa cikin ruwa mai ruɓaɓɓen ciki (intrathecal chemotherapy), wani sashin jiki, ko rami na jiki kamar ciki, magungunan yawanci suna shafar ƙwayoyin cutar kansa a waɗancan yankuna (yankin yanki). Haɗaɗɗiyar cutar sankarar magani ita ce magani ta amfani da fiye da ɗaya maganin ƙwayar cutar sankara.

Hanyar da ake ba da cutar sankara ta dogara da nau'in cutar sankara. A cikin AML, ana amfani da chemotherapy da aka bayar ta bakin, jijiyoyi, ko cikin ruwan ciki.

A cikin AML, ƙwayoyin cutar sankarar bargo na iya yaɗuwa zuwa cikin kwakwalwa da / ko laka. Chemotherapy da aka bayar ta baki ko jiji don magance AML bazai ƙetare shingen kwakwalwar jini ba don shiga cikin ruwan da ke kewaye da kwakwalwa da lakar kashin baya. Madadin haka, ana yi wa allurar rigakafin cutar cikin wani fili mai cike da ruwa don kashe kwayoyin cutar sankarar bargo wanda wataƙila ya bazu a can (intrathecal chemotherapy).

Intrathecal chemotherapy. Magungunan anticancer ana allurarsu a cikin sararin samaniya, wanda shine sararin da ke riƙe da ruwan sanyin jiki (CSF, wanda aka nuna a shuɗi). Akwai hanyoyi daban-daban guda biyu don yin wannan. Wata hanya, da aka nuna a saman ɓangaren adadi, ita ce a yi amfani da allurar ƙwayoyin a cikin wani tafki na Ommaya (akwati mai kama da dome wanda aka sanya shi a ƙarƙashin fatar kan mutum yayin aikin tiyata; yana riƙe da magungunan yayin da suke shiga ta cikin ƙaramin bututu zuwa cikin kwakwalwa ). Wata hanyar, wanda aka nuna a cikin ɓangaren ƙasa na adadi, shine a yi allurar ƙwayoyi kai tsaye zuwa CSF a cikin ƙananan ɓangaren kashin baya, bayan an lasafta wani ƙaramin yanki a ƙasan baya.

Dubi Magungunan da aka Amince da Ciwon Cutar Myeloid Mai Ciwo don ƙarin bayani.

Radiation far

Radiation therapy magani ne na cutar kansa wanda yake amfani da hasken rana mai ƙarfi ko wasu nau'ikan radiation don kashe ƙwayoyin kansa ko hana su girma. Akwai nau'o'in maganin radiation guda biyu:

• Magungunan radiation na waje yana amfani da inji a waje don aika radiation zuwa ga cutar kansa.

• Magungunan radiation na ciki yana amfani da abu mai tasirin rediyo wanda aka rufe a cikin allurai, tsaba, wayoyi, ko catheters waɗanda aka sanya kai tsaye zuwa ko kusa da ciwon daji.

Hanyar da ake ba da maganin taɗɗar radiation ya dogara da nau'in cutar kansa da ake kula da ita. A cikin yarinta na AML, ana iya amfani da maganin radiation na waje don magance chloroma wanda ba ya karɓar magani.

Dasawar dasa kara

Ana ba da magani don kashe ƙwayoyin kansa ko wasu ƙwayoyin jini mara kyau. Kwayoyin lafiya, gami da ƙwayoyin halitta masu jini, suma ana lalata su ta hanyar maganin kansa. Dasawar sel shine magani don maye gurbin kwayoyin halitta. Ana cire ƙwayoyin sari (ƙwayoyin jinin da basu balaga ba) daga cikin jinin ko ƙashin ƙashin mara lafiya ko mai bayarwa kuma ana daskarar dasu ana adana su. Bayan mai haƙuri ya gama shan magani, sai a narke ƙwayoyin ƙwayoyin da aka adana kuma a mayar da su ga mai haƙuri ta hanyar jiko. Waɗannan ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin magungunan za a ɗibar

Dasawar dasa kara (Mataki na 1): Ana ɗaukar jini daga jijiya a hannun mai bayarwa. Mai haƙuri ko wani mutum na iya zama mai ba da gudummawa. Jinin yana gudana ta cikin injin da ke cire ƙwayoyin sel. Sannan jinin yana dawowa ga mai bayarwa ta wata jijiya a daya hannun. (Mataki 2): Mai haƙuri yana karɓar magani don kashe ƙwayoyin halitta. Mai haƙuri na iya karɓar maganin radiation (ba a nuna ba). (Mataki na 3): Mai haƙuri yana karɓar ƙwayoyin sel ta hanyar catheter da aka sanya a cikin jijiyoyin jini a cikin kirji.

Ciwon da aka yi niyya

Targeted therapy wani nau'in magani ne wanda yake amfani da magunguna ko wasu abubuwa don ganowa da afkawa takamaiman ƙwayoyin cutar kansa ba tare da cutar ƙwayoyin halitta ba. Nau'o'in maganin da aka yi niyya sun haɗa da masu zuwa:

• Tyrosine kinase inhibitor therapy: Tyrosine kinase inhibitor (TKI) far yana toshe siginar da ake buƙata don ciwace ciwace. TKI suna toshe enzyme (tyrosine kinase) wanda ke sa ƙwayoyin sel su zama fararen ƙwayoyin jini (fashewa) fiye da jiki. Ana iya amfani da TKI tare da magunguna don maganin adjuvant (magani da aka bayar bayan jiyya ta farko, don rage haɗarin cewa ciwon kansa zai dawo).

• Imatinib, dasatinib, da nilotinib nau'ikan TKI ne waɗanda ake amfani dasu don kula da ƙananan yara na CML.

• Ana karatun Sorafenib da trametinib game da cutar sankarar bargo ta yara.

• Magungunan rigakafi na Monoclonal : Magungunan antibody na Monoclonal yana amfani da ƙwayoyin cuta waɗanda aka yi a cikin dakin gwaje-gwaje, daga nau'in kwayar halitta guda. Wadannan kwayoyin cuta na iya gano abubuwan da ke jikin kwayoyin cutar kansar ko kuma wasu abubuwa na yau da kullun wadanda zasu iya taimakawa kwayoyin halittar cutar kansa. Kwayoyin rigakafin suna haɗuwa da abubuwan kuma suna kashe ƙwayoyin cutar kansa, toshe haɓakar su, ko kiyaye su daga yaɗuwa. Ana ba da ƙwayoyin cuta na Monoclonal ta hanyar jiko. Ana iya amfani da su su kaɗai ko ɗaukar ƙwayoyi, gubobi, ko kayan aikin rediyo kai tsaye zuwa ƙwayoyin kansa.

• Gemtuzumab wani nau'in antibody ne wanda yake haɗe da magani na chemotherapy. Ana amfani dashi wajen maganin AML.

Selinexor magani ne wanda ake niyya don maganin rashin ƙarfi ko maimaita yarinta AML.

Dubi Magungunan da aka Amince da cutar sankarar bargo don ƙarin bayani.

Sauran maganin magani

Ana iya amfani da Lenalidomide don rage buƙatun ƙarin jini a cikin marasa lafiya waɗanda ke da ƙwayoyin cuta na myelodysplastic da ke haifar da wani canjin chromosome na musamman. Hakanan ana nazarinsa a cikin kula da yara tare da maimaitawa da kuma rashin ƙarfi AML.

Arsenic trioxide da all-trans retinoic acid (ATRA) magunguna ne da ke kashe wasu nau'ikan kwayoyin cutar sankarar bargo, dakatar da cutar sankarar jini daga rarrabawa, ko taimakawa ƙwayoyin sankarar jini su zama fararen jini. Ana amfani da waɗannan magungunan don magance cutar sankarar bargo mai saurin yaduwa.

Dubi Magungunan da aka Amince da Ciwon Cutar Myeloid Mai Ciwo don ƙarin bayani.

Jiran jira

Tsayawa a hankali yana lura da yanayin mai haƙuri ba tare da ba da wani magani ba har sai alamu ko alamu sun bayyana ko canzawa. Wani lokacin ana amfani dashi don magance MDS ko myelopiesis mara ƙyau (mara).

Taimakon tallafi

Ana ba da kulawa na tallafi don rage matsalolin da cutar ta haifar ko kuma maganinta. Duk marasa lafiya da cutar sankarar bargo suna karɓar magungunan kulawa na tallafi. Taimako na tallafi na iya haɗa da masu zuwa:

• Maganin ƙarin jini: Hanya ce ta ba da jajayen jini, fararen ƙwayoyin jini, ko platelets don maye gurbin ƙwayoyin jinin da cuta ko maganin kansa ya lalata. Ana iya ba da gudummawar jinin daga wani mutum ko kuma an karɓa daga mara lafiyar a baya an adana shi har sai an buƙata.

• Magungunan ƙwayoyi, kamar su maganin rigakafi ko wakilan antifungal.

• Leukapheresis: Hanya ce wacce ake amfani da inji na musamman don cire fararen ƙwayoyin jini daga cikin jini. Ana karɓar jini daga majiyyacin kuma a saka ta cikin mai raba tantanin jini inda ake cire farin ƙwayoyin jinin. Sauran jinin sai a mayar da su cikin jinin mara lafiyar. Ana amfani da Leukapheresis don magance marasa lafiya tare da ƙidayar ƙwanƙolin fararen ƙwayar jini ƙwarai.

Ana gwada sababbin nau'ikan magani a gwajin asibiti.

Wannan ɓangaren taƙaitaccen bayani yana bayanin jiyya waɗanda ake nazarin su a gwajin asibiti. Yana iya ba ambaci kowane sabon magani ana nazarin. Ana samun bayani game da gwaji na asibiti daga gidan yanar gizon NCI.

Immunotherapy

Immunotherapy magani ne wanda ke amfani da garkuwar jikin mara lafiya don yaƙar kansa. Abubuwan da jiki ya yi ko aka yi a dakin gwaje-gwaje ana amfani da su don haɓaka, kai tsaye, ko maido da kariya ta jiki daga cutar kansa. Wannan nau'in maganin cutar kansa ana kiransa biotherapy ko ilimin halittu.

Marasa lafiya na iya son yin tunani game da shiga cikin gwaji na asibiti.

Ga wasu marasa lafiya, shiga cikin gwaji na asibiti na iya zama mafi kyawun zaɓin magani. Gwajin gwaji wani bangare ne na aikin binciken cutar kansa. Ana yin gwaje-gwajen asibiti don gano ko sabbin maganin cutar daji suna da lafiya da tasiri ko kuma sun fi magani na yau da kullun.

Yawancin yau da kullun na yau da kullun don cutar kansa sun dogara ne akan gwajin asibiti na farko. Marasa lafiya da ke cikin gwaji na asibiti na iya karɓar daidaitaccen magani ko kuma su kasance cikin farkon waɗanda za su karɓi sabon magani.

Marasa lafiya da ke shiga cikin gwaji na asibiti suma suna taimakawa inganta hanyar da za a bi da kansar a nan gaba. Koda lokacin gwajin asibiti bai haifar da sababbin magunguna ba, sau da yawa sukan amsa mahimman tambayoyi kuma suna taimakawa ci gaba da bincike gaba.

Marasa lafiya na iya shiga gwajin asibiti kafin, lokacin, ko bayan fara maganin cutar kansa. Wasu gwaji na asibiti kawai sun haɗa da marasa lafiya waɗanda ba su sami magani ba tukuna. Sauran gwaje-gwajen suna gwada jiyya ga marasa lafiya waɗanda cutar kansa ba ta samu sauki ba. Hakanan akwai gwaji na asibiti da ke gwada sabbin hanyoyin dakatar da cutar kansa daga sake dawowa (dawowa) ko rage tasirin maganin kansar.

Gwajin gwaji na gudana a sassa da yawa na ƙasar. Bayani game da gwajin asibiti wanda NCI ke tallafawa ana iya samun shi akan shafin binciken gwaji na NCI. Ana iya samun gwajin gwaji na asibiti wanda wasu kungiyoyi ke tallafawa akan gidan yanar gizon ClinicalTrials.gov.

Ana iya buƙatar gwaje-gwaje na gaba.

Za a iya maimaita wasu gwaje-gwajen da aka yi don gano cutar kansa ko don gano matakin cutar kansa. Za a maimaita wasu gwaje-gwaje don ganin yadda magani ke aiki. Shawarwari game da ci gaba, canji, ko dakatar da magani na iya dogara ne da sakamakon waɗannan gwaje-gwajen.

Wasu daga cikin gwaje-gwajen za a ci gaba da yi daga lokaci zuwa lokaci bayan an gama jiyya. Sakamakon waɗannan gwaje-gwajen na iya nuna idan yanayin ɗanku ya canza ko kuma idan ciwon daji ya sake dawowa (dawo). Wadannan gwaje-gwajen wasu lokuta ana kiran su gwaje-gwaje na gaba ko dubawa.

Zaɓuɓɓukan Jiyya don Ciwon Cutar Myeloid Mai Ciwon Yara

Don bayani game da jiyya da aka jera a ƙasa, duba sashin Kula da Zaɓin Jiyya.

Jiyya na sabuwar cutar da ta kamu da cutar sankarar bargo ta yara (AML) a lokacin shigarwar na iya haɗa da masu zuwa:

• Hade chemotherapy.

• Anyi niyya tare da antibody na monoclonal (gemtuzumab).

• Tsarin kulawa na tsakiya na maganin rigakafin cuta tare da intrathecal chemotherapy.

• Radiation radiation, ga marasa lafiya tare da sarcoma na granulocytic (chloroma) idan chemotherapy baya aiki.

• Tsarin dasa kara, ga marasa lafiya tare da AML mai nasaba da jinya.

Jiyya na AML na ƙuruciya yayin lokacin gafarar (ƙarfafawa / ƙarfafawa) ya dogara da ƙaramin nau'in AML kuma yana iya haɗawa da masu zuwa:

• Hade chemotherapy.

• Chemwararren ƙwayar ƙwayar ƙwayar cuta ta bi ta hanyar amfani da ƙwayoyin jini daga mai bayarwa.

Jiyya na ƙarancin yarinta AML na iya haɗa da masu zuwa:

• Lenalidomide far.

• Gwajin gwaji na ilimin kimiya da magani (selinexor).

• Wani sabon tsarin hada magani.

Jiyya na ƙaramar yarinta AML na iya haɗawa da masu zuwa:

• Hade chemotherapy.

• Haɗuwa da cutar sankara da kuma kara kwayar halitta, ga marasa lafiyar da suka sami gafarar kammalawa karo na biyu.

• Tsarin dashen sel na biyu, ga marasa lafiya wadanda cutar ta dawo bayan dashen sel na farko.

• Gwajin gwaji na ilimin kimiya da magani (selinexor).

Zaɓuɓɓukan Jiyya don Ciwon Cutar Myelopoiesis na Tarshe ko Yaran da ke fama da Rashin Lafiya da AML

Don bayani game da jiyya da aka jera a ƙasa, duba sashin Kula da Zaɓin Jiyya.

Myelopoiesis mara kyau mara kyau (TAM) yawanci yakan tafi da kansa. Don TAM wanda baya tafiya da kansa ko haifar da wasu matsalolin lafiya, magani na iya haɗawa da masu zuwa:

• Kulawa mai tallafi, gami da maganin ƙarin jini ko leukapheresis.

• Chemotherapy.

Jiyya na cutar sankarar bargo na myeloid (AML) a cikin yara masu shekaru 4 ko ƙarami waɗanda ke da cutar Down Down na iya haɗa da masu zuwa:

• Haɗuwa da cutar sankarar jiki tare da tsarin kulawa na tsakiya mai kula da maganin rigakafi tare da intrathecal chemotherapy.

• Gwajin gwaji na sabon tsarin kula da cutar sankara wanda ya danganta da yadda yaron ya amsa maganin farko.

Kulawa da AML a cikin yara sama da shekaru 4 waɗanda ke da cutar rashin lafiya na iya zama daidai da magani ga yara ba tare da ciwon Down ba.

Zaɓuɓɓukan Jiyya don Ciwon Cutar Ciwan yara na Ciwon Yara

Don bayani game da jiyya da aka jera a ƙasa, duba sashin Kula da Zaɓin Jiyya.

Jiyya na sabon cututtukan yara mai saurin yaduwar cutar sankarar bargo (APL) na iya haɗa da masu zuwa:

• All-trans retinoic acid (ATRA) tare da chemotherapy.

• Arsenic trioxide far.

• Gwajin gwaji na ATRA da maganin arsenic trioxide tare da ko ba tare da ilimin kimiya ba.

Jiyya na APL na yara yayin lokacin gafartawa (ƙarfafawa / haɓaka ƙarfi) na iya haɗa da masu zuwa:

• All-trans retinoic acid (ATRA) tare da chemotherapy.

Jiyya na yara APL na yara zasu iya haɗa da masu zuwa:

• Arsenic trioxide far.

• Duk-trans retinoic acid far (ATRA) tare da chemotherapy.

• Anyi niyya tare da antibody na monoclonal (gemtuzumab).

• Dasawar sel mai amfani da kwayoyin kara jini daga mara lafiya ko mai bayarwa.

Zaɓuɓɓukan Jiyya don Ciwon yara Myelomonocytic Cutar sankarar bargo

Don bayani game da jiyya da aka jera a ƙasa, duba sashin Kula da Zaɓin Jiyya.

Kula da cutar sankarar bargo na yara (JMML) na iya haɗa da masu zuwa:

• Haɗuwa da cutar sankara ta hanyar bin kwayar halitta. Idan JMML ya sake dawowa bayan dasawar kwayar halitta, ana iya yin dashen sel na biyu.

Jiyya na ƙyama ko maimaita ƙuruciya JMML na iya haɗawa da masu zuwa:

• Gwajin gwaji na maganin farfadowa tare da mai hana yaduwar cutar tyrosine kinase (trametinib).

Zaɓuɓɓukan Jiyya don Ciwon Cutar Ciwan Yara na Yara

Don bayani game da jiyya da aka jera a ƙasa, duba sashin Kula da Zaɓin Jiyya.

Jiyya don cutar sankarar bargo na yara (CML) na iya haɗa da masu zuwa:

• Anyi niyya tare da mai hana cin hanci da rashawa (imatinib, dasatinib, ko nilotinib).

Jiyya na ƙiyayya ko maimaita yarinta CML na iya haɗa da mai zuwa:

• Neman da aka yi niyya tare da mai hana cin hanci da rashawa (dasatinib ko nilotinib).

• Dasawar sel mai amfani da kwayoyin kara jini daga mai bayarwa.

Zaɓuɓɓukan Jiyya don Ciwan ƙananan yara na Myelodysplastic

Don bayani game da jiyya da aka jera a ƙasa, duba sashin Kula da Zaɓin Jiyya.

Jiyya na ƙananan ƙwayoyin cuta na ƙananan ƙwayoyin cuta (MDS) na iya haɗa da masu zuwa:

• Dasawar sel mai amfani da kwayoyin kara jini daga mai bayarwa.

• Kulawa mai tallafi, gami da maganin ƙarin jini da maganin rigakafi.

• Lenalidomide far, ga marasa lafiya da wasu canje-canje na kwayar halitta.

• Gwajin gwaji na asibiti.

Idan MDS ta zama cutar sankarar myeloid na musamman (AML), magani zai zama iri ɗaya ne da magani na sabon AML.

Don ƙarin koyo game da Ciwon Cutar Myeloid na Yara da Childhoodarancin Cutar Myeloid

Don ƙarin bayani daga Cibiyar Ciwon aboutwayar Ciwon aboutasa game da cutar sankarar bargo na yara da sauran cututtukan myeloid, duba waɗannan:

• An Amince da Magunguna don Ciwon Cutar Myeloid Mai Ciwo

• Magunguna da Aka Amince da Myeloproliferative Neoplasms

• Tattara Kwayoyin Halitta mai Yin jini

• Magungunan Ciwon Cutar da Aka Yi niyya

Don ƙarin bayani game da cutar sankarar yara da sauran albarkatun kansar gaba ɗaya, duba masu zuwa:

• Game da Ciwon daji

• Ciwon Yara

• Binciken Cure don Ciwon Childrenan yara

• Matsayi na Late na Jiyya don Ciwon Yara

• Matasa da Samari da Ciwon daji

• Yara da Ciwon daji: Jagora ga Iyaye

• Ciwon daji a cikin Yara da Matasa

• Tsayawa

• Yin fama da Ciwon daji

• Tambayoyi don Tambayar Doctor game da Ciwon daji

• Don Tsira da Kulawa