Nau'o'in / cutar sankarar bargo / haƙuri / yaro-duka-magani-pdq
Abubuwan da ke ciki
Kulawa da cutar sankarar bargo ta yara (®) –Patient Version
Janar Bayani Game da Ciwon Cutar Cutar Sanyi na Yara
MAGANAN MAGANA
- Matsalar cutar sankarar bargo ta yara (ALL) wani nau'in ciwon daji ne wanda kashin ƙashi yake sa ƙwayoyin lymphocytes da basu balaga ba (wani nau'in farin jini).
- Cutar sankarar bargo na iya shafar jajayen ƙwayoyin jini, fararen ƙwayoyin jini, da kuma platelets.
- Maganin da ya gabata na cutar kansa da wasu halaye na gado suna shafar haɗarin samun yarinta ALL.
- Alamomin yarinta DUK sun hada da zazzabi da zafin jiki.
- Ana amfani da gwaje-gwajen da ke bincikar jini da ƙashin ƙashi don ganowa (samo) da bincika ƙuruciya DUK.
- Wasu dalilai suna tasiri hangen nesa (damar dawowa) da zaɓuɓɓukan magani.
Matsalar cutar sankarar bargo ta yara (ALL) wani nau'in ciwon daji ne wanda kashin ƙashi yake sa ƙwayoyin lymphocytes da basu balaga ba (wani nau'in farin jini).
Yammacin cutar sankarar bargo na yara (wanda ake kira DUK ko kuma cutar sankarar bargo) yana da ciwon daji na jini da ƙashi. Irin wannan ciwon daji yakan zama da sauri idan ba a magance shi ba.
KOWANE shine mafi yawan nau'in ciwon daji a cikin yara.
Cutar sankarar bargo na iya shafar jajayen ƙwayoyin jini, fararen ƙwayoyin jini, da kuma platelets.
A cikin lafiyayyen yaro, ƙashin kashin baya yana sanya ƙwayoyin jini na jini (ƙwayoyin da ba su balaga ba) waɗanda suka zama ƙwararrun ƙwayoyin jini a kan lokaci. Stemwayar ƙwayar ƙwayar jini na iya zama ƙwayar ƙwayar myeloid ko ƙwayar ƙwayar ƙwayar lymphoid.
Kwayar kara kuzari ta myeloid ta zama ɗayan nau'ikan nau'ikan ƙwayoyin jini uku masu girma:
- Jajayen jini wadanda suke daukar iskar oxygen da sauran abubuwa zuwa dukkan kyallen takarda.
- Platelets wadanda suke samar da daskararren jini dan tsaida zubar jini.
- Farin jini wanda ke yakar kamuwa da cuta.
Kwayar kwayar lymphoid ta zama kwayar lymphoblast sannan ɗayan nau'ikan ƙwayoyin lymphocytes guda uku (fararen ƙwayoyin jini):
- B lymphocytes wanda ke yin rigakafi don taimakawa yaƙi da kamuwa da cuta.
- T lymphocytes masu taimakawa B lymphocytes suna yin ƙwayoyin cuta waɗanda ke taimakawa yaƙi da kamuwa da cuta.
- Kwayoyin kisa na halitta wadanda ke kai hari kan ƙwayoyin daji da ƙwayoyin cuta.
A cikin yaron da ke da ALL, ƙwayoyin sel da yawa sun zama lymphoblasts, B lymphocytes, ko T lymphocytes. Kwayoyin ba sa aiki kamar kwayoyin lymphocytes na yau da kullun kuma ba sa iya yaƙi kamuwa da cuta da kyau. Waɗannan ƙwayoyin ƙwayoyin cuta ne na kansa (leukemia). Hakanan, yayin da adadin kwayar cutar sankarar jini ke ƙaruwa a cikin jini da ƙashin ƙashi, akwai ƙarancin wuri don lafiyayyun ƙwayoyin farin jini, jajayen ƙwayoyin jini, da platelets. Wannan na iya haifar da kamuwa da cuta, karancin jini, da saurin zubar jini.
Wannan taƙaitaccen bayani ne game da cutar sankarar bargo ta yara ta yara, matasa, da matasa. Duba takaitattun masu zuwa don bayani game da wasu nau'ikan cutar sankarar bargo:
- Yaran Ciwon Cutar Myeloid Mai Ciwo / Sauran Maganin Cutar Myeloid
- Kulawa da Ciwon Cutar sankarar bargo na manya
- Magungunan cutar sankarar bargo na yau da kullun
- Kulawa da Ciwon Cutar sankarar Myeloid na Matasa
- Magungunan cutar sankarar bargo na zamani
- Jiyya Kwayar Cutar sankarar bargo
Maganin da ya gabata na cutar kansa da wasu halaye na gado suna shafar haɗarin samun yarinta ALL.
Duk wani abu da zai kara maka hadarin kamuwa da cuta to ana kiran sa mai hadari. Samun haɗari ba ya nufin cewa za ku kamu da cutar kansa; ba tare da haɗarin abubuwan haɗari ba yana nufin cewa ba zaku sami cutar kansa ba. Yi magana da likitan ɗanka idan kana tunanin ɗanka na cikin haɗari.
Abubuwan haɗarin haɗari ga DUK sun haɗa da masu zuwa:
- Kasancewa da hasken rana kafin haihuwa.
- Kasancewa ga radiation.
- Maganin da ya gabata tare da chemotherapy.
- Samun wasu halaye na kwayar halitta, kamar:
- Ciwon rashin lafiya.
- Neurofibromatosis nau'in 1.
- Ciwon Bloom.
- Fanconi anemia
- Ataxia-telangiectasia.
- Ciwon Li-Fraumeni.
- Rashin daidaitaccen gyaran tsarin mulki (maye gurbi a wasu kwayoyin halittar da ke dakatar da DNA daga gyara kanta, wanda ke haifar da karuwar cutar sankara tun yana karami).
- Samun wasu canje-canje a cikin chromosomes ko genes.
Alamomin yarinta DUK sun hada da zazzabi da zafin jiki.
Waɗannan da sauran alamomi da alamun cutar na iya haifar da ƙuruciya DUK ko ta wasu yanayi. Binciki likitan ɗanka idan ɗanka yana da ɗayan masu zuwa:
- Zazzaɓi.
- Aramar rauni ko zubar jini.
- Petechiae (lebur, nunin wuri, duhu-ja-ja a karkashin fata sanadiyyar zubar jini).
- Kashi ko haɗin gwiwa.
- Lumanƙara mara zafi a cikin wuya, mara wuya, ciki, ko makwancin ciki.
- Jin zafi ko jin cikawa ƙasa da haƙarƙarin.
- Rauni, jin kasala, ko kodadde.
- Rashin ci.
Ana amfani da gwaje-gwajen da ke bincikar jini da ƙashin ƙashi don ganowa (samo) da bincika ƙuruciya DUK.
Ana iya amfani da gwaje-gwaje da hanyoyin da za a iya amfani da su don bincika ƙuruciya DUK kuma gano idan ƙwayoyin cutar sankarar bargo sun bazu zuwa wasu sassan jiki kamar ƙwaƙwalwa ko ƙwaraji:
Jarabawa ta jiki da tarihi: Jarabawa ce ta jiki don bincika alamomin lafiya gaba ɗaya, gami da bincika alamun cuta, kamar kumburi ko wani abu da kamar baƙon abu. Za a kuma ɗauki tarihin al'adun lafiyar marasa lafiya da cututtukan da suka gabata da magunguna.
Cikakken ƙidayar jini (CBC) tare da banbanci: Hanyar da za'a zana samfurin jini kuma a bincika ta mai zuwa:
- Yawan jajayen kwayoyin jini da platelets.
- Adadi da nau'in farin jini.
- Adadin haemoglobin (furotin da ke ɗauke da iskar oxygen) a cikin ƙwayoyin jinin jini.
- Yankin samfurin ya kunshi jajayen ƙwayoyin jini.
- Nazarin ilimin sunadarai na jini: Hanya ce wacce ake bincikar samfurin jini don auna adadin wasu abubuwa da aka saki a cikin jini ta gabobi da kayan aiki a jiki. Adadin abu na yau da kullun (mafi girma ko ƙasa da al'ada) na iya zama alamar cuta.
- Burin kasusuwan kasusuwa da biopsy: Cire kasusuwan kasusuwa da karamin guntun kashi ta hanyar sanya allura mara kyau a cikin kashin hanji ko kashin mama. Wani masanin ilimin cututtukan fata yana kallon kasusuwan kasusuwa da ƙashi a ƙarƙashin microscope don neman alamun cutar kansa.
Ana yin gwaje-gwaje masu zuwa akan jini ko ƙwayar jijiyar ƙashi da aka cire:
- Nazarin Cytogenetic: Gwajin dakin gwaje-gwaje wanda aka kirga chromosomes na kwayoyi a cikin samfurin jini ko jiji da kashi don bincika kowane canje-canje, kamar karye, ɓacewa, sake gyarawa, ko ƙarin ƙwanƙwanni. Canje-canje a cikin wasu chromosomes na iya zama alamar cutar kansa. Misali, a cikin Philadelphia chromosome – tabbatacce DUK, ɓangare na chromosome ɗaya yana sauya wurare tare da wani ɓangaren wani chromosome. Ana kiran wannan "chromosome na Philadelphia." Ana amfani da nazarin Cytogenetic don taimakawa gano cutar kansa, shirya magani, ko gano yadda magani ke aiki.
- Immunophenotyping: Gwajin dakin gwaje-gwaje da ke amfani da kwayoyin cuta don gano kwayoyin cutar kansar dangane da nau'ikan antigens ko alamomi a saman sel. Ana amfani da wannan gwajin don taimakawa wajen gano takamaiman nau'ikan cutar sankarar bargo. Misali, ana bincikar kwayoyin cutar kansa don ganin ko su lymphocytes ne B ko kuma lymphocytes na T.
- Lumbar puncture: Hanya ce da ake amfani da ita don tattara samfurin ruwan ciki (CSF) daga sashin kashin baya. Ana yin wannan ta sanya allura tsakanin ƙasusuwa biyu a cikin kashin baya da kuma cikin CSF a kewayen ƙashin baya da cire samfurin ruwan. An bincika samfurin CSF a ƙarƙashin microscope don alamun da ke nuna cewa cutar sankarar bargo ta bazu zuwa kwakwalwa da laka. Wannan hanyar ana kiranta LP ko taɓar kashin baya.
Ana yin wannan aikin bayan an gano cutar sankarar bargo don gano ko ƙwayoyin cutar sankarar bargo sun bazu zuwa cikin kwakwalwa da laka. Ana ba da Intrathecal chemotherapy bayan an cire samfurin ruwa don magance duk ƙwayoyin cutar sankarar bargo da ka iya yaɗuwa zuwa cikin kwakwalwa da lakar kashin baya.
- Kirjin x-ray: X-ray na gabobin da kasusuwa a cikin kirji. X-ray wani irin katako ne na katako wanda zai iya ratsa jiki zuwa fim, yana yin hoton wurare a cikin jiki. Ana yin x-ray a kirji don ganin idan kwayoyin cutar sankarar bargo sun sami taro a tsakiyar kirjin.
Wasu dalilai suna tasiri hangen nesa (damar dawowa) da zaɓuɓɓukan magani.
Hangen nesa (damar dawowa) ya dogara da:
- Yaya sauri da kuma yadda ƙananan kwayar cutar sankarar jini ta sauka bayan watan farko na jiyya.
- Shekaru a lokacin ganewar asali, jima'i, launin fata, da kuma asalin ƙabila.
- Adadin fararen ƙwayoyin jini a cikin jini a lokacin ganewar asali.
- Ko kwayoyin cutar sankarar bargo sun fara daga lymphocytes B ko lymphocytes T.
- Ko akwai wasu canje-canje a cikin chromosomes ko kwayoyin halittar lymphocytes masu cutar kansa.
- Ko yaron yana da cutar rashin lafiya.
- Ko ana samun kwayoyin cutar sankarar bargo a cikin ruwar sankara.
- Nauyin yaron a lokacin ganewar asali da yayin magani.
Zaɓuɓɓukan magani sun dogara da:
- Ko kwayoyin cutar sankarar bargo sun fara daga lymphocytes B ko lymphocytes T.
- Ko yaron yana da mizanin mai-haɗari, mai-haɗari, ko mai tsananin haɗari ALL.
- Shekarun yaro a lokacin ganewar asali.
- Ko akwai wasu canje-canje a cikin chromosomes na lymphocytes, kamar su Philadelphia chromosome.
- Ko an yiwa yaron magani tare da steroid kafin fara maganin shigar da ciki.
- Yaya sauri da kuma yadda ƙananan ƙwayar cutar sankarar jini ya saukad da lokacin magani.
Don cutar sankarar jini wanda ya sake dawowa (ya dawo) bayan jiyya, hangen nesa da zaɓuɓɓukan magani sun dogara da ɓangarorin masu zuwa:
- Yaya tsawon lokacin tsakanin lokacin bincike da lokacin da cutar sankarar jini ta dawo.
- Ko cutar sankarar bargo ta dawo a cikin kashin kashi ko kuma a wasu sassan jiki.
Sungiyoyin Hadari don Ciwon Cutar Lymphoblastic Leukemia
MAGANAN MAGANA
- A lokacin yarinta DUK, ana amfani da ƙungiyoyin haɗari don tsara magani.
- Sake dawo da yarinta DUK cutar kansa ce da ta dawo bayan an warke.
A lokacin yarinta DUK, ana amfani da ƙungiyoyin haɗari don tsara magani.
Akwai rukuni uku masu haɗari a yarinta ALL. An bayyana su kamar haka:
- Haɗari mai sauƙi (mara ƙasa): Ya haɗa da yara 'yan shekara 1 zuwa ƙasa da shekaru 10 waɗanda ke da ƙwan jinin farin jini ƙasa da 50,000 / µL a lokacin ganewar asali.
- Babban haɗari: Ya haɗa da yara 10 shekaru zuwa sama da / ko yara waɗanda ke da ƙwaryar ƙwayar jinin jini na 50,000 / orL ko fiye a lokacin ganewar asali.
- Babban haɗari mai haɗari: Ya haɗa da yara masu ƙarancin shekaru 1, yara da ke da wasu canje-canje a cikin ƙwayoyin halittar, yara waɗanda ke da jinkirin amsawa ga magani na farko, da yara waɗanda ke da alamun cutar sankarar bargo bayan makonni 4 na farko na jiyya.
Sauran abubuwan da suka shafi ƙungiyar haɗari sun haɗa da masu zuwa:
- Ko kwayoyin cutar sankarar bargo sun fara daga lymphocytes B ko lymphocytes T.
- Ko akwai wasu canje-canje a cikin chromosomes ko kwayoyin halittar lymphocytes.
- Yaya sauri da kuma yadda ƙananan kwayar cutar sankarar jini ke saukad da magani na farko.
- Ko ana samun kwayoyin cutar sankarar bargo a cikin ruwan sankara a lokacin bincike.
Yana da mahimmanci a san ƙungiyar haɗari don tsara shirin magani. Yaran da ke da haɗari ko masu haɗarin gaske DUK yawanci suna karɓar ƙarin ƙwayoyin cuta da / ko mafi yawan ƙwayoyin maganin anticancer fiye da yara masu daidaitaccen-DUK.
Sake dawo da yarinta DUK cutar kansa ce da ta dawo bayan an warke.
Cutar sankarar bargo na iya dawowa cikin jini da kashin kashi, kwakwalwa, lakar kashin baya, gwaiba, ko wasu sassan jiki.
Yammacin yara DUK cutar kansa ce da ba ta amsa magani.
Bayanin Zaɓin Jiyya
MAGANAN MAGANA
- Akwai nau'ikan magani daban-daban na cutar sankarar jini na yara (ALL).
- Yaran da ke tare da ALL yakamata ƙungiyar likitoci waɗanda suka ƙware kan kula da cutar sankarar bargo ta yara.
- Jiyya don ƙananan cutar sankarar bargo na yara na iya haifar da illa.
- Maganin yarinta DUK yawanci yana da matakai uku.
- Ana amfani da nau'i hudu na daidaitaccen magani:
- Chemotherapy
- Radiation far
- Chemotherapy tare da dasawa da kwayar halitta
- Ciwon da aka yi niyya
- Ana ba da magani don kashe ƙwayoyin cutar sankarar bargo waɗanda suka bazu ko na iya yaɗuwa zuwa cikin kwakwalwa, lakar kashin baya, ko ƙwanjiji.
- Ana gwada sababbin nau'ikan magani a gwajin asibiti.
- Chimeric antigen receptor (CAR) Maganin T-cell
- Marasa lafiya na iya son yin tunani game da shiga cikin gwaji na asibiti.
- Marasa lafiya na iya shiga gwajin asibiti kafin, lokacin, ko bayan fara maganin cutar kansa.
- Ana iya buƙatar gwaje-gwaje na gaba.
Akwai nau'ikan magani daban-daban na cutar sankarar jini na yara (ALL).
Akwai nau'ikan magani daban-daban wa yara masu fama da cutar sankarar bargo (ALL). Wasu jiyya suna daidaito (magani da ake amfani dashi yanzu), kuma wasu ana gwada su a gwajin asibiti. Gwajin gwajin magani shine binciken bincike wanda aka tsara don taimakawa inganta ingantattun jiyya na yanzu ko samun bayanai game da sababbin jiyya ga marasa lafiya da ciwon daji. Lokacin da gwaji na asibiti ya nuna cewa sabon magani ya fi magani na yau da kullun, sabon magani na iya zama daidaitaccen magani.
Saboda cutar kansa a cikin yara ba safai ba, ya kamata a yi la'akari da shiga cikin gwajin asibiti. Wasu gwaji na asibiti ana buɗe su ne kawai ga marasa lafiyar da basu fara magani ba.
Yaran da ke tare da ALL yakamata ƙungiyar likitoci waɗanda suka ƙware kan kula da cutar sankarar bargo ta yara. Jiyya za ta kula da likitan ilimin likitan yara, likita wanda ya kware kan kula da yara masu cutar kansa. Masanin ilimin likitan yara yana aiki tare da wasu ƙwararrun likitocin yara waɗanda ƙwararru ne wajen kula da yara masu cutar sankarar bargo kuma waɗanda suka kware a wasu fannonin magani. Wadannan na iya hada da kwararru masu zuwa:
- Likitan yara.
- Likitan cututtukan ciki.
- Masanin ilimin likita na ilimin likita.
- Likitan likitan yara.
- Radiation oncologist
- Neurologist.
- Masanin ilimin cututtuka.
- Masanin radiyo.
- Kwararren likitan yara.
- Ma'aikacin zamantakewa.
- Gwanayen gyarawa.
- Masanin ilimin psychologist.
- Kwararren rayuwar yara.
Jiyya don ƙananan cutar sankarar bargo na yara na iya haifar da illa.
Don bayani game da illolin da ke farawa yayin magani don cutar kansa, duba shafin Gurbinmu.
Gwajin bin diddigi na da matukar mahimmanci. Hanyoyi masu illa daga maganin ciwon daji wanda zai fara bayan jiyya kuma ya ci gaba tsawon watanni ko shekaru ana kiransa sakamako na ƙarshe.
Sakamakon sakamako na maganin kansa na iya haɗa da masu zuwa:
- Matsalolin jiki, gami da matsaloli na zuciya, magudanar jini, hanta, ko ƙasusuwa, da haihuwa. Lokacin da aka ba dexrazoxane tare da magungunan ƙwayar cuta wanda ake kira anthracyclines, haɗarin ƙarshen tasirin zuciya yana raguwa.
- Canje-canje a cikin yanayi, ji, tunani, ilmantarwa, ko ƙwaƙwalwar ajiya. Yaran da ke ƙasa da shekaru 4 waɗanda suka karɓi maganin ƙwanƙwasawa zuwa kwakwalwa suna da haɗarin waɗannan halayen.
- Cancer na biyu (sababbin nau'ikan cutar kansa) ko wasu yanayi, kamar su ciwan ƙwaƙwalwa, kansar kawanda, myeloid leukemia, da myelodysplastic syndrome.
Wasu maganganun ƙarshen ana iya magance su ko sarrafa su. Yana da mahimmanci a yi magana da likitocin ɗanka game da yiwuwar ƙarshen cututtukan da wasu jiyya suka haifar. Duba taƙaitaccen bayanin akan ƙarshen tasirin Magani ga Ciwon kansa na Childhoodananan yara.
Maganin yarinta DUK yawanci yana da matakai uku.
Maganin yarinta DUK ana yin sa ne a matakai:
- Shigar da aikin gafarwa: Wannan shine farkon lokacin magani. Burin shine a kashe kwayoyin cutar sankarar bargo a cikin jini da kashin kashi. Wannan ya sanya cutar sankarar bargo cikin gafara.
- Haɗawa / ƙaruwa: Wannan shine kashi na biyu na magani. Yana farawa ne da zarar cutar sankarar jini ta kasance cikin gafara. Manufar karfafawa / kara karfi shine a kashe duk kwayoyin cutar sankarar bargo wadanda suka rage a jiki kuma zai iya haifar da koma baya.
- Kulawa: Wannan shine kashi na uku na magani. Makasudin shine a kashe sauran ƙwayoyin cutar sankarar bargo waɗanda zasu iya sakewa kuma su haifar da koma baya. Yawancin lokaci ana ba da jiyya akan ƙananan ƙwayoyi fiye da waɗanda aka yi amfani da su yayin shigar da gafara da haɓakawa / haɓaka ƙarfi. Rashin shan magani kamar yadda likita yayi umarni yayin gyaran kulawa yana kara damar cutar kansa zata dawo. Wannan ana kiransa mahimmancin ci gaban farfadowa.
Ana amfani da nau'i hudu na daidaitaccen magani:
Chemotherapy
Chemotherapy magani ne na cutar kansa wanda ke amfani da magunguna don dakatar da haɓakar ƙwayoyin kansa, ko dai ta hanyar kashe ƙwayoyin ko ta hana su rarraba. Lokacin da ake shan chemotherapy ta baki ko allura a cikin jijiya ko tsoka, magungunan suna shiga cikin jini kuma zasu iya kaiwa ga kwayoyin cutar kansa a cikin jiki duka (chemotherapy systemic). Lokacin da aka sanya chemotherapy kai tsaye zuwa cikin ruwa mai ruɓaɓɓen ciki (intrathecal), wani sashin jiki, ko rami na jiki kamar ciki, magungunan yawanci suna shafar ƙwayoyin kansa ne a waɗancan yankuna (chemotherapy na yanki). Haɗaɗɗiyar cutar sanadiyyar magani magani ne ta amfani da fiye da ɗaya maganin ƙwayar cutar kansa.
Hanyar da ake ba da cutar sankara ta dogara da ƙungiyar masu haɗarin yaron. Yaran da ke da babban haɗari DUK suna karɓar ƙarin ƙwayoyi masu hana cutar kansa da kuma yawan adadin magungunan anticancer fiye da yara masu daidaitaccen-haɗari ALL. Intrathecal chemotherapy ana iya amfani dashi don kula da ƙuruciya DUK abin da ya bazu, ko na iya yaɗuwa, zuwa kwakwalwa da laka.
Duba Magungunan da aka Amince dasu don Ciwon Cutar sankaran Lymphoblastic don ƙarin bayani.
Radiation far
Radiation therapy magani ne na cutar kansa wanda yake amfani da hasken rana mai ƙarfi ko wasu nau'ikan radiation don kashe ƙwayoyin kansa ko hana su girma. Akwai nau'o'in maganin radiation guda biyu:
- Magungunan radiation na waje yana amfani da inji a waje don aika radiation zuwa ga cutar kansa.
- Magungunan radiation na ciki yana amfani da abu mai tasirin rediyo wanda aka rufe a cikin allurai, tsaba, wayoyi, ko catheters waɗanda aka sanya kai tsaye zuwa ko kusa da ciwon daji.
Hanyar da ake ba da maganin fitilar ya dogara da nau'in cutar kansa da ake kula da ita. Za'a iya amfani da maganin radiation na waje don kula da ƙuruciya DUK abin da ya bazu, ko zai iya yaɗuwa, zuwa kwakwalwa, lakar kashin baya, ko ƙwarjiyoyin jini. Hakanan za'a iya amfani dashi don shirya ƙashin ƙashi don sashin ƙwayar ƙwayar ƙwayar ƙwayar cuta.
Chemotherapy tare da dasawa da kwayar halitta
Chemotherapy kuma wani lokacin ana ba da hasken iska gaba ɗaya don kashe ƙwayoyin kansa. Kwayoyin lafiya, gami da ƙwayoyin halitta masu jini, suma ana lalata su ta hanyar maganin kansa. Dasawar sel shine magani don maye gurbin kwayoyin halitta. Ana cire ƙwayoyin sari (ƙwayoyin jinin da basu balaga ba) daga cikin jinin ko ƙashin ƙashin mara lafiya ko mai bayarwa kuma ana daskarar dasu ana adana su. Bayan mai haƙuri ya gama shan magani da kuma kulawar fure, ana narke ƙwayoyin ƙwayoyin da aka adana kuma a mayar da su ga mai haƙuri ta hanyar jiko. Waɗannan ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin na ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin magungunan za a ɗibar
Ba safai ake amfani da dasa ƙwarƙwara ba azaman magani na farko ga yara da matasa tare da ALL. Ana amfani dashi sau da yawa azaman ɓangaren magani ga DUK wanda ya sake dawowa (ya dawo bayan jiyya).
Duba Magungunan da aka Amince dasu don Ciwon Cutar sankaran Lymphoblastic don ƙarin bayani.
Ciwon da aka yi niyya
Targeted therapy wani magani ne wanda yake amfani da magunguna ko wasu abubuwa don ganowa da afkawa takamaiman ƙwayoyin kansa ba tare da cutar ƙwayoyin halitta ba. Akwai nau'ikan maganin farfadowa daban-daban:
- Tyrosine kinase inhibitors (TKIs) su ne magunguna masu niyya wanda ke toshe enzyme, tyrosine kinase, wanda ke haifar da ƙwayoyin jini su zama farar ƙwayoyin jini ko fashewa fiye da yadda jiki ke buƙata. Imatinib mesylate TKI ce da ake amfani da ita wajen kula da yara tare da Philadelphia chromosome-tabbatacce ALL. Dasatinib da ruxolitinib sune TKI waɗanda ake karatunsu don magance sabon haɗarin haɗari ALL.
- Magungunan antibody na Monoclonal magani ne na ciwon daji wanda ke amfani da ƙwayoyin cuta da aka yi a cikin dakin gwaje-gwaje, daga nau'in kwayar halitta guda ɗaya. Wadannan kwayoyin cuta na iya gano abubuwan da ke jikin kwayoyin cutar kansar ko kuma wasu abubuwa na yau da kullun wadanda zasu iya taimakawa kwayoyin halittar cutar kansa. Kwayoyin rigakafin suna haɗuwa da abubuwan kuma suna kashe ƙwayoyin cutar kansa, toshe haɓakar su, ko kiyaye su daga yaɗuwa. Ana ba da ƙwayoyin cuta na Monoclonal ta hanyar jiko. Ana iya amfani da su su kaɗai ko ɗaukar ƙwayoyi, gubobi, ko kayan aikin rediyo kai tsaye zuwa ƙwayoyin kansa. Blinatumomab da inotuzumab sune kwayoyin cutar monoclonal da ake nazarinsu a kula da ƙarancin yarinta DUK.
- Magungunan hanawa na proteasome wani nau'in magani ne da aka niyya wanda yake toshe aikin proteasomes a cikin ƙwayoyin kansa. Proteasomes suna cire sunadaran da kwayar halitta take buƙata. Lokacin da aka toshe proteasomes, sunadaran suna ginawa a cikin tantanin halitta kuma yana iya haifar da kwayar cutar kansa ta mutu. Bortezomib wani nau'in maganin hana yaduwar cuta ne wanda ake amfani dashi don magance sakewar yarinta DUK.
Sabbin nau'ikan hanyoyin kwantar da hankalin da ake niyya suma ana nazarin su a kula da ƙuruciya ALL.
Duba Magungunan da aka Amince dasu don Ciwon Cutar sankaran Lymphoblastic don ƙarin bayani.
Ana ba da magani don kashe ƙwayoyin cutar sankarar bargo waɗanda suka bazu ko na iya yaɗuwa zuwa cikin kwakwalwa, lakar kashin baya, ko ƙwanjiji.
Jiyya don kashe ƙwayoyin cutar sankarar bargo ko hana yaduwar ƙwayoyin cutar sankarar bargo zuwa kwakwalwa da lakar jijiyoyi (tsarin jijiyoyi na tsakiya; CNS) ana kiranta kulawar da aka ba da ta CNS. Ana iya amfani da Chemotherapy don magance ƙwayoyin cutar sankarar bargo waɗanda suka bazu, ko kuma su yaɗu, zuwa kwakwalwa da lakar kashin baya. Saboda daidaitattun allurai na chemotherapy bazai isa ƙwayoyin cutar sankarar jini a cikin CNS ba, ƙwayoyin suna iya ɓoyewa a cikin CNS. Chemotherapy na tsarin da aka bayar a babban allurai ko intrathecal chemotherapy (a cikin ruwa mai ruɓanyawa) yana iya isa ƙwayoyin cutar sankarar bargo a cikin CNS. Wani lokaci kuma ana ba da maganin fitilar waje zuwa kwakwalwa.
Ana ba da waɗannan magungunan ban da magani wanda ake amfani da shi don kashe ƙwayoyin cutar sankarar jini a cikin sauran jikin. Duk yara tare da ALL suna karɓar maganin CNS a matsayin ɓangare na farfadowa da haɓakawa da ƙarfafawa da kuma wani lokacin yayin maganin kulawa.
Idan kwayar cutar sankarar jini ta bazu zuwa kwaɗɗar mahaifa, magani ya haɗa da yawan ƙwayoyin cuta na yau da kullun kuma wani lokacin maganin fitila.
Ana gwada sababbin nau'ikan magani a gwajin asibiti.
Wannan ɓangaren taƙaitaccen bayani yana bayanin jiyya waɗanda ake nazarin su a gwajin asibiti. Yana iya ba ambaci kowane sabon magani ana nazarin. Ana samun bayani game da gwaji na asibiti daga gidan yanar gizon NCI.
Chimeric antigen receptor (CAR) Maganin T-cell
CAR T-cell therapy wani nau'i ne na rigakafi wanda ke canza ƙwayoyin T mai haƙuri (wani nau'in kwayar garkuwar jiki) don haka zasu afkawa wasu sunadarai a saman ƙwayoyin kansa. Ana ɗaukar ƙwayoyin T daga mai haƙuri kuma an ƙara masu karɓa na musamman zuwa saman su a cikin dakin gwaje-gwaje. Sel ɗin da aka canza ana kiran su ƙwayoyin chimeric antigen receptor (CAR) T. Kwayoyin CAR T suna girma a cikin dakin gwaje-gwaje kuma ana ba mai haƙuri ta hanyar jiko. Kwayoyin CAR T suna ninka cikin jinin mai haƙuri kuma suna kai wa ƙwayoyin kansa hari. Ana nazarin karatun C-T-cell a cikin kula da ƙuruciya DUK abin da ya sake dawowa (ya dawo) a karo na biyu.
Marasa lafiya na iya son yin tunani game da shiga cikin gwaji na asibiti.
Ga wasu marasa lafiya, shiga cikin gwaji na asibiti na iya zama mafi kyawun zaɓin magani. Gwajin gwaji wani bangare ne na aikin binciken cutar kansa. Ana yin gwaje-gwajen asibiti don gano ko sabbin maganin cutar daji suna da lafiya da tasiri ko kuma sun fi magani na yau da kullun.
Yawancin yau da kullun na yau da kullun don cutar kansa sun dogara ne akan gwajin asibiti na farko. Marasa lafiya da ke cikin gwaji na asibiti na iya karɓar daidaitaccen magani ko kuma su kasance cikin farkon waɗanda za su karɓi sabon magani.
Marasa lafiya da ke shiga cikin gwaji na asibiti suma suna taimakawa inganta hanyar da za a bi da kansar a nan gaba. Koda lokacin gwajin asibiti bai haifar da sababbin magunguna ba, sau da yawa sukan amsa mahimman tambayoyi kuma suna taimakawa ci gaba da bincike gaba.
Marasa lafiya na iya shiga gwajin asibiti kafin, lokacin, ko bayan fara maganin cutar kansa.
Wasu gwaji na asibiti kawai sun haɗa da marasa lafiya waɗanda ba su sami magani ba tukuna. Sauran gwaje-gwajen suna gwada jiyya ga marasa lafiya waɗanda cutar kansa ba ta samu sauki ba. Hakanan akwai gwaji na asibiti da ke gwada sabbin hanyoyin dakatar da cutar kansa daga sake dawowa (dawowa) ko rage tasirin maganin kansar.
Gwajin gwaji na gudana a sassa da yawa na ƙasar. Bayani game da gwajin asibiti wanda NCI ke tallafawa ana iya samun shi akan shafin binciken gwaji na NCI. Ana iya samun gwajin gwaji na asibiti wanda wasu kungiyoyi ke tallafawa akan gidan yanar gizon ClinicalTrials.gov.
Ana iya buƙatar gwaje-gwaje na gaba.
Za a iya maimaita wasu gwaje-gwajen da aka yi don gano cutar kansa ko don gano matakin cutar kansa. Za a maimaita wasu gwaje-gwaje don ganin yadda magani ke aiki. Shawarwari game da ci gaba, canji, ko dakatar da magani na iya dogara ne da sakamakon waɗannan gwaje-gwajen.
Wasu daga cikin gwaje-gwajen za a ci gaba da yi daga lokaci zuwa lokaci bayan an gama jiyya. Sakamakon waɗannan gwaje-gwajen na iya nuna idan yanayin ɗanku ya canza ko kuma idan ciwon daji ya sake dawowa (dawo). Wadannan gwaje-gwajen wasu lokuta ana kiran su gwaje-gwaje na gaba ko dubawa.
Burin kasusuwan kasusuwa da biopsy ana yin su a duk lokutan magani don ganin yadda maganin ke gudana.
Zaɓuɓɓukan Jiyya don Ciwon Cutar Ciwan Yara na Yara
A Wannan Sashin
- Sabon Ciwon Hannun Cutar Ciwon Cutar Lifemi (Ciwon Tsari)
- Sabon Ciwon Hannun Cutar Ciwon Cutar Lememmiya (Babban Hadarin)
- Sabon Ciwon Hannun Cutar Ciwon Cutar Sanyi na Yara (Babban Hadari)
- Sabon Ciwon Hannun Cutar Ciwan Cutar Lifemi (Groupungiyoyi na Musamman)
- T-cell yara m lymphoblastic cutar sankarar bargo
- Jarirai tare da DUK
- Yara 10 shekaru zuwa sama da samari tare da ALL
- Philadelphia chromosome – tabbatacce DUK
- Matsanancin Ciwo na Ciwon Cutar Liman
- Raunin Rashin Lafiyar Childhoodan yara da ke fama da cutar sankarau
Don bayani game da jiyya da aka jera a ƙasa, duba sashin Kula da Zaɓin Jiyya.
Sabon Ciwon Hannun Cutar Ciwon Cutar Lifemi (Ciwon Tsari)
Yin maganin cutar sankarar bargo mai saurin yaduwar yara (ALL) yayin shigar da gafara, karfafawa / karfafawa, da matakan kulawa koyaushe sun hada da hadewar magani. Lokacin da yara ke cikin gafara bayan farfajiyar shigar da gafara, ana iya yin dashen ƙwayar ƙwaya ta amfani da ƙwayoyin sel daga mai bayarwa. Lokacin da yara basa cikin gafara bayan farfajiyar shigar da gafara, ƙarin magani yawanci shine irin maganin da ake yiwa yara masu haɗari ALL.
Intrathecal chemotherapy ana bayarwa don hana yaduwar kwayoyin cutar sankarar bargo zuwa cikin kwakwalwa da laka.
Magungunan da ake karantawa a cikin gwaji na asibiti don daidaitaccen-haɗari DUK sun hada da sabbin hanyoyin maganin sankara.
Yi amfani da binciken bincikenmu na asibiti don nemo NCI na goyan bayan gwajin asibiti wanda ke karɓar marasa lafiya. Kuna iya bincika gwaji dangane da nau'in ciwon daji, shekarun mai haƙuri, da kuma inda ake yin gwajin. Ana samun cikakken bayani game da gwaji na asibiti.
Sabon Ciwon Hannun Cutar Ciwon Cutar Lememmiya (Babban Hadarin)
Yin maganin cutar sankarar bargo na yara mai saurin haɗari (ALL) yayin shigar da gafara, ƙarfafawa / haɓakawa, da matakan kulawa koyaushe sun haɗa da haɗuwa da ƙwayar cuta. Yaran da ke cikin haɗarin haɗari DUK ƙungiyar ana ba su ƙarin magungunan antiancer da ƙananan ƙwayoyi na maganin anticancer, musamman ma yayin lokacin ƙarfafawa / ƙarfafawa, fiye da yara a cikin ƙungiyar mai haɗarin haɗari.
Intrathecal da system chemotherapy ana ba su don hana ko magance yaduwar ƙwayoyin cutar sankarar jini zuwa kwakwalwa da laka. Wani lokaci kuma ana ba da maganin radiation a cikin kwakwalwa.
Magungunan da ake karantawa a cikin gwajin asibiti don haɗarin haɗari DUK sun haɗa da sababbin tsarin ilimin sankarar magani tare da ko ba tare da maganin da aka yi niyya ba ko sashin ƙwayar ƙwayar ƙwayar cuta.
Yi amfani da binciken bincikenmu na asibiti don nemo NCI na goyan bayan gwajin asibiti wanda ke karɓar marasa lafiya. Kuna iya bincika gwaji dangane da nau'in ciwon daji, shekarun mai haƙuri, da kuma inda ake yin gwajin. Ana samun cikakken bayani game da gwaji na asibiti.
Sabon Ciwon Hannun Cutar Ciwon Cutar Sanyi na Yara (Babban Hadari)
Maganin cutar sankarar bargo mai saurin haɗari ga yara (ALL) yayin shigar da gafara, ƙarfafawa / haɓakawa, da matakan kulawa koyaushe sun haɗa da haɗuwa da ƙwayar cuta. Yara a cikin mawuyacin haɗari DUK ƙungiya ana ba su ƙarin maganin rigakafi fiye da yara a cikin ƙungiyar mai haɗarin gaske. Babu tabbacin ko dasawar kwayar halitta da aka yi a lokacin gafarar farko zai taimaka wa yaron ya yi tsawon rai.
Intrathecal da system chemotherapy ana ba su don hana ko magance yaduwar ƙwayoyin cutar sankarar jini zuwa kwakwalwa da laka. Wani lokaci kuma ana ba da maganin radiation a cikin kwakwalwa.
Magungunan da ake karantawa a cikin gwaji na asibiti don haɗari mai haɗari DUK sun haɗa da sababbin tsarin ilimin sankarar magani tare da ko ba tare da niyya ba.
Yi amfani da binciken bincikenmu na asibiti don nemo NCI na goyan bayan gwajin asibiti wanda ke karɓar marasa lafiya. Kuna iya bincika gwaji dangane da nau'in ciwon daji, shekarun mai haƙuri, da kuma inda ake yin gwajin. Ana samun cikakken bayani game da gwaji na asibiti.
Sabon Ciwon Hannun Cutar Ciwan Cutar Lifemi (Groupungiyoyi na Musamman)
T-cell yara m lymphoblastic cutar sankarar bargo
Kula da cutar sankarar bargo na yara (ALL) yayin cutar sankara, ƙarfafawa / haɓakawa, da matakan kulawa koyaushe sun haɗa da haɗarin cutar sankara. Yaran da ke da T-cell DUK an ba su ƙarin magungunan ƙwayar cuta da kuma yawan kwayoyi masu maganin ciwon sankara fiye da yara a cikin sabon ƙungiyar da aka gano.
Intrathecal da system chemotherapy ana ba su don hana yaduwar kwayoyin cutar sankarar bargo zuwa kwakwalwa da laka. Wani lokaci kuma ana ba da maganin radiation a cikin kwakwalwa.
Magungunan da ake nazarin su a cikin gwajin asibiti don T-cell DUK sun haɗa da sababbin jami'ai masu maganin ciwon daji da magungunan ƙwararraji tare da ko ba tare da niyya ba.
Jarirai tare da DUK
Kula da jarirai tare da DUK lokacin shigarda gafara, ƙarfafawa / ƙarfafawa, da matakan kulawa koyaushe sun haɗa da haɗuwa da ƙwayar cuta. Ana ba jarirai masu DUKAN magunguna daban-daban da kuma yawan kwayoyi masu rikitarwa fiye da yara 'yan shekara 1 zuwa sama a cikin ƙungiyar mai haɗarin haɗari. Babu tabbacin ko dasawar kwayar halitta da aka yi a lokacin gafarar farko zai taimaka wa yaron ya yi tsawon rai.
Intrathecal da system chemotherapy ana ba su don hana yaduwar kwayoyin cutar sankarar bargo zuwa kwakwalwa da laka.
Magungunan da ake nazarin su a cikin gwajin asibiti ga jarirai tare da ALL sun haɗa da cutar shan magani ga jarirai tare da wani canjin kwayar halitta.
Yara 10 shekaru zuwa sama da samari tare da ALL
Maganin DUK a cikin yara da matasa (shekaru 10 zuwa sama) yayin shigar da gafara, ƙarfafawa / haɓakawa, da matakan kulawa koyaushe sun haɗa da haɗuwa da ƙwayar cuta. Yara 10an shekaru 10 da haihuwa da matasa tare da ALL ana ba su ƙarin magungunan ƙwayar cuta da ƙananan ƙwayoyi na maganin rigakafin fiye da yara a cikin ƙungiyar haɗarin haɗari.
Intrathecal da system chemotherapy ana ba su don hana yaduwar kwayoyin cutar sankarar bargo zuwa kwakwalwa da laka. Wani lokaci kuma ana ba da maganin radiation a cikin kwakwalwa.
Magungunan da ake nazarin su a cikin gwajin asibiti na yara shekaru 10 zuwa sama da samari tare da ALL sun haɗa da sabbin jami'ai masu maganin cutar sankara da kuma maganin ƙwaƙwalwar tare da ko ba tare da niyya ba.
Philadelphia chromosome – tabbatacce DUK
Maganin Philadelphia chromosome - tabbataccen yarinta DUK lokacin shigarda gafara, ƙarfafawa / haɓakawa, da matakan kulawa zasu iya haɗa da masu zuwa:
- Haɗuwa da cututtukan ƙwayar cuta da kuma maganin farfadowa tare da mai hana maganin tyrosine kinase (imatinib mesylate) tare da ko ba tare da wani ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ta hanyar amfani da ƙwayoyin ƙwayoyin daga mai bayarwa ba.
Magungunan da ake karantawa a gwaji na asibiti don ƙarancin chromosome na Philadelphia-tabbatacce yara DUK sun haɗa da sabon tsarin kula da niyya (imatinib mesylate) da haɗuwa da ƙwayar cuta tare da ko ba tare da sashin ƙwayar ƙwayar ba.
Yi amfani da binciken bincikenmu na asibiti don nemo NCI na goyan bayan gwajin asibiti wanda ke karɓar marasa lafiya. Kuna iya bincika gwaji dangane da nau'in ciwon daji, shekarun mai haƙuri, da kuma inda ake yin gwajin. Ana samun cikakken bayani game da gwaji na asibiti.
Matsanancin Ciwo na Ciwon Cutar Liman
Babu daidaitaccen magani don maganin cututtukan sankarar ƙwayar lymphoblastic mai ƙananan yara (ALL).
Jiyya na ƙarancin ƙuruciya DUK na iya haɗa da mai zuwa:
- Maƙasudin farfadowa (blinatumomab ko inotuzumab).
- Chimeric antigen receptor (CAR) Maganin T-cell.
Raunin Rashin Lafiyar Childhoodan yara da ke fama da cutar sankarau
Ingantaccen magani game da cutar sankarar jini mai saurin lalacewar yara (ALL) wanda ya dawo cikin jijiyar ƙashi na iya haɗa da masu zuwa:
- Haɗakar chemotherapy tare ko ba tare da niyya far (bortezomib).
- Tsarin dasawar kara, ta yin amfani da kwayoyin kara daga mai bayarwa.
Ingantaccen magani game da cutar sankarar jini mai saurin lalacewar yara (ALL) wanda ya dawo baya ga ƙashin ƙashi na iya haɗawa da masu zuwa:
- Chemotherapy na yau da kullun da intrathecal chemotherapy tare da maganin radiation zuwa kwakwalwa da / ko laka don ciwon daji wanda ya dawo cikin kwakwalwa da ƙashin baya kawai.
- Haɗuwa da cutar sankara da kera raɗaɗɗa don cutar kansa wanda ke dawowa cikin ƙwayoyin cuta kawai.
- Dasawar sel mai tushe don cutar kansa wanda ya sake komawa cikin kwakwalwa da / ko laka.
Wasu daga cikin maganin da ake karatun a gwajin asibiti don sake komawa yarinta DUK sun haɗa da:
- Wani sabon tsari na hade hadewar magani da kuma niyya (blinatumomab).
- Wani sabon nau'in magani na chemotherapy.
- Chimeric antigen receptor (CAR) Maganin T-cell.
Yi amfani da binciken bincikenmu na asibiti don nemo NCI na goyan bayan gwajin asibiti wanda ke karɓar marasa lafiya. Kuna iya bincika gwaji dangane da nau'in ciwon daji, shekarun mai haƙuri, da kuma inda ake yin gwajin. Ana samun cikakken bayani game da gwaji na asibiti.
Don Morearin Koyo game da Ciwon Cutar Sanyi na Ciwon Yara
Don ƙarin bayani daga Cibiyar Ciwon cerwayar Ciwon acuteasa game da cutar sankarar jini ta ƙananan yara, duba mai zuwa:
- Tomography Tomography (CT) Scans da Ciwon daji
- An Amintar da Magunguna don Ciwon Cutar Liman
- Tattara Kwayoyin Halitta mai Yin jini
- Magungunan Ciwon Cutar da Aka Yi niyya
Don ƙarin bayani game da cutar sankarar yara da sauran albarkatun kansar gaba ɗaya, duba masu zuwa:
- Game da Ciwon daji
- Ciwon Yara
- Binciken Cure don Ciwon Childrenan yara
- Matsayi na Late na Jiyya don Ciwon Yara
- Matasa da Samari da Ciwon daji
- Yara da Ciwon daji: Jagora ga Iyaye
- Ciwon daji a cikin Yara da Matasa
- Tsayawa
- Yin fama da Ciwon daji
- Tambayoyi don Tambayar Doctor game da Ciwon daji
- Don Tsira da Kulawa
