Game da-ciwon daji / jiyya / gwaji-na asibiti / cuta / extragonadal-germ-cell-ƙari / magani

Gwajin Gwani na Gwaji don Extragonadal Germ Cell Tumor

Gwajin gwaji shine karatun bincike wanda ya shafi mutane. Gwajin gwaji na wannan jerin sune don maganin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta. Duk gwaji akan jerin suna samun tallafi daga NCI.

Babban bayanin NCI game da gwajin asibiti yayi bayanin nau'ikan da matakan gwajin da yadda ake aiwatar dasu. Gwajin gwaji na duba sabbin hanyoyin kariya, ganowa, ko magance cuta. Kuna so kuyi tunani game da shiga cikin gwajin gwaji. Yi magana da likitanka don taimako yayin yanke shawara idan ɗaya ya dace maka.

Gwaji 1-7 na 7

Kulawa mai aiki, Bleomycin, Carboplatin, Etoposide, ko Cisplatin a Kula da Yara da Yara Manya tare da Ciwon ƙwayar ƙwayar Jari

Wannan gwajin na lokaci na uku yana nazarin yadda kulawa mai kyau, bleomycin, carboplatin, etoposide, ko cisplatin ke aiki don kula da yara da manya marasa lafiya tare da ƙwayar ƙwayar ƙwayar ƙwayar cuta. Kulawa mai aiki na iya taimaka wa likitoci su lura da batutuwa da ƙananan ƙwayoyin ƙwayoyin ƙwayoyin cuta bayan an cire ƙwayar cutar. Magungunan da ake amfani da su a chemotherapy, kamar bleomycin, carboplatin, etoposide, da cisplatin, suna aiki ta hanyoyi daban-daban don dakatar da haɓakar ƙwayoyin tumo, ko dai ta hanyar kashe ƙwayoyin, ta hana su rarraba, ko ta hana su yaɗuwa.

Wuri: wurare 435

Celeara sauri ko Tsarin BEP Chemotherapy a Kula da Marasa lafiya tare da Matsakaici ko orananan -unƙarar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta

Wannan gwajin lokaci na bazuwar yayi nazarin yadda ingantaccen jadawalin bleomycin sulfate, etoposide phosphate, da cisplatin (BEP) chemotherapy ke aiki idan aka kwatanta da jadawalin jadawalin BEP chemotherapy wajen kula da marasa lafiya tare da matsakaici ko ƙwayoyin cuta ƙwayoyin cuta waɗanda suka bazu zuwa wasu wurare a cikin jiki (metastatic). Magungunan da ake amfani da su a cikin cutar sankara, kamar su bleomycin sulfate, etoposide phosphate, da cisplatin, suna aiki ta hanyoyi daban-daban don dakatar da haɓakar ƙwayoyin tumo, ko dai ta hanyar kashe ƙwayoyin, ta hana su rarraba, ko ta hana su yaɗuwa. Bada BEP chemotherapy akan saurin, ko "hanzarta" jadawalin na iya aiki mafi kyau tare da ƙananan sakamako masu illa a kula da marasa lafiya tare da matsakaici ko ƙarancin haɗarin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta idan aka kwatanta da daidaitaccen tsarin.

Wuri: Wurare 126

Daidaitaccen Comadadden Chemotherapy ko -wararren Comwararren mwararren mwararriyar andwayar da Cellwayar Cellwayar inwayar don Kula da Marasa lafiya tare da orsanƙarar ƙwayar ƙwayar ƙwayar ƙwayar cuta

Wannan gwajin na bazuwar III yayi nazarin yadda daidaitaccen maganin hade-hade yake aiki idan aka kwatanta shi da babban maganin hade hade da dashen kwayar halitta a kula da marasa lafiya da kwayar cutar kwayar cutar wacce ta dawo bayan wani cigaba na cigaba ko ba ta amsa magani ba. Magungunan da ake amfani da su a chemotherapy, kamar paclitaxel, ifosfamide, cisplatin, carboplatin, da etoposide, suna aiki ta hanyoyi daban-daban don dakatar da ci gaban ƙwayoyin tumo, ko dai ta hanyar kashe ƙwayoyin, ta hanyar dakatar da su daga rarraba, ko kuma ta hana su yaɗuwa. Bada chemotherapy kafin dasawar kwayar halitta ta dakatar da ci gaban kwayoyin cutar kansa ta hanyar dakatar dasu daga rarraba ko kashe su. Bayar da abubuwa masu motsa sha'awa, kamar filgrastim ko pegfilgrastim, da wasu magungunan ƙwayoyi na chemotherapy, yana taimaka wa kwayoyin halitta su motsa daga kasusuwan kasusuwa zuwa jini don haka za'a iya tara su a adana su. Ana ba Chemotherapy don shirya kashin ƙashi don dashen ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta. Daga nan sai a mayar da sel masu tushe ga mai haƙuri don maye gurbin ƙwayoyin halittar jini waɗanda aka lalata ta hanyar maganin cutar sankara. Har yanzu ba a sani ba ko yawan kwaya mai hade-hade da dasawar kwayar halitta ya fi tasiri fiye da daidaitaccen maganin hade-hade wajen kula da marassa lafiya tare da raunin kwayar cutar kwayar cutar.

Wuri: Wurare 54

Durvalumab da Tremelimumab a Kula da Marasa lafiya tare da Raunin Tashin ƙwayoyin ƙwayoyin cuta

Wannan gwajin na lokaci na II yana nazarin yadda durvalumab da tremelimumab ke aiki da kyau wajen kula da marasa lafiya da ƙwayoyin cuta na ƙwayoyin cuta waɗanda suka dawo bayan wani lokaci na ci gaba ko ba sa amsa magani. Immunotherapy tare da kwayoyin cuta na monoclonal, irin su durvalumab da tremelimumab, na iya taimaka wa garkuwar jiki ta yaƙi kansar, kuma yana iya tsoma baki tare da ikon ƙwayoyin ƙari don girma da yaɗuwa.

Wuri: Wurare 7

Autologous Tsarin Tsarin Tsarin Tsarin Jikin Jikin Hannun Halitta don Ciwon Cellwayar mwayar Gerarjin

Zaɓuɓɓukan magani don sake dawowa ko ƙyamar ƙwayar ƙwayar ƙwayar ƙwayar cuta (GCT) marasa lafiya sun iyakance. Magungunan ƙwayar cuta mai mahimmanci tare da ceton kwayar halitta (ƙwaƙwalwar ƙwayar ƙwayar ƙwayar ƙwayar cuta), lokacin da aka ba su a jere, ya nuna cewa rukunin marasa lafiya na iya warkewa. Tsarin ingantaccen magani mai ƙoshin lafiya, ba a sani ba. A cikin wannan gwajin, zamu yi amfani da daskararrun daskararrun abubuwa tare da tsarin sanyaya yanayin mara tsayayyiyar hanya don kula da marasa lafiya tare da koma baya / sakewa GCTs.

Wuri: Jami'ar Minnesota / Cibiyar Cancer ta Masonic, Minneapolis, Minnesota

Melphalan, Carboplatin, Mannitol, da Sodium Thiosulfate a Kula da Marasa Lafiya tare da Maimaitawa ko Ci Gaban CNS Embryonal ko Ciwon Tananan ƙwayoyin cuta na Germ

Wannan gwajin na I / II yana nazarin illoli da mafi kyawun kashi na melphalan lokacin da aka ba su tare da carboplatin, mannitol, da sodium thiosulfate, da kuma ganin yadda suke aiki tukuru wajen kula da marasa lafiya tare da ci gaba ko ci gaban tsarin juyayi na tsakiya (CNS) embryonal ko ƙwayar cuta cell ciwace. Magungunan da ake amfani da su a jiyyar cutar sankara, kamar su melphalan da carboplatin, suna aiki ta hanyoyi daban-daban don dakatar da ci gaban ƙwayoyin tumo, ko dai ta hanyar kashe ƙwayoyin, ta hana su rarraba, ko ta hana su yaɗuwa. Rushewar shinge-ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa (BBBD) tana amfani da mannitol don buɗe magudanan jini a kewayen kwakwalwa da ba da damar ɗaukar abubuwan kashe kansa da kai tsaye zuwa kwakwalwa. Sodium thiosulfate na iya taimakawa ragewa ko hana raunin ji da yawan guba a cikin marasa lafiyar da ke shan magani tare da carboplatin da BBBD.

Wuri: Wurare 2

Adjuvant Tumor Lysate Vaccine da Iscomatrix Tare da ko Ba tare da Metronomic Oral Cyclophosphamide da Celecoxib a cikin Marasa lafiya Tare da Matsalar da ke Cikin Huhu, Esophagus, Pleura, ko Mediastinum

Bayan Fage: A cikin 'yan shekarun nan, antigens-Cant (CT) antigens (CTA), musamman waɗanda keɓaɓɓu da ƙwayoyin halitta a kan kwayar halittar X chromosome (ƙwayoyin CT-X), sun bayyana a matsayin kyakkyawar manufa don rigakafin rigakafin cutar kansa. Ganin cewa cutarwa na tarihi daban-daban suna bayyana nau'ikan CTA daban-daban, amsoshin rigakafi ga waɗannan sunadarai sun zama baƙon abu a cikin marasa lafiya na kansar, mai yiwuwa saboda ƙaramin matakin, maganganun antigen iri daban-daban, da kuma ƙwayoyin T masu rigakafin rigakafi waɗanda ke cikin cikin rukunin ƙwayoyin cuta da zagayawa na waɗannan mutane. . Tabbas, rigakafin masu cutar kansa tare da ƙwayoyin tumo waɗanda ke bayyana manyan matakan CTA a haɗe tare da tsarin da ya ƙare ko hana ƙwayoyin halitta na T zai haifar da cikakken rigakafi ga waɗannan antigens. Don bincika wannan batun, marasa lafiya da ke fama da cutar huhu ta farko da cututtukan hanji, ƙarancin jijiyoyin jiki, sarracas na thoracic, cututtukan ƙwayoyin cuta da ƙwayoyin cuta, da sarcomas, melanomas, ciwace-ciwacen ƙwayoyin cuta, ko cututtukan cututtukan ƙwayar cuta wanda ke haɗuwa da huhu, pleura ko mediastinum ba tare da shaidar cutar ba (NED) ko ƙananan ragowar cuta (MRD) bin madaidaiciyar maganin multidisciplinary. alurar riga kafi tare da H1299 cell lysates tare da Iscomatrix adjuvant. Za a yi amfani da allurar rigakafin tare da ko ba tare da cyclophosphamide na maganin metronomic ba (50 mg PO BID x 7d q 14d), da celecoxib (400 mg PO BID). Maganganu na serologic ga yawancin CTA masu sake haɗuwa tare da martani na rigakafi game da ƙari na autologous ko haɓakar asalin halittar EBVtransformed lymphocytes za a kimanta kafin da bayan watanni na rigakafin. Manufofin farko: 1. Don kimanta yawan maganin rigakafin cutar ga CTA a cikin marasa lafiya da cututtukan thoracic bayan bin allurar rigakafi tare da maganin rigakafin H1299 cell lysate / Iscomatrix (TM) shi kadai in aka kwatanta da marasa lafiya da cututtukan ƙwayar cuta bayan bin allurar rigakafin tare da H1299 cell lysate / Iscomatrix allurar rigakafi tare da metronomic cyclophosphamide da celecoxibib . Makasudin Makarantar Sakandare: 1. Don bincika idan maganin metronomic na cyclophosphamide da magani na celecoxib yana rage lamba da kashi na kwayoyin sarrafa T kuma yana rage ayyukan wadannan kwayoyin a cikin marasa lafiya masu cutar cutar thoracic suna cikin hadarin sake dawowa. 2. Don bincika idan maganin alurar rigakafin kwayar H1299 / Iscomatrix (TM) na inganta maganin rigakafi ga maganin ƙwaƙwalwar ƙwayar cuta ko haɓakaccen haɓakaccen kwayar halitta ta EBV-ta canza ƙwayoyin lymphocytes (ƙwayoyin B). Cancantar: - Marasa lafiya da ke da ilimin tarihi ko kuma ilimin kimiyyar sihiri wanda ba shi da ƙananan ƙwayoyin huhu (SCLC; NSCLC), ciwon sankarar mahaifa (EsC), muguwar jijiyoyin jijiyoyin jiki (MPM), cututtukan ƙwayoyin cuta na kwayar cuta, ko sarkewa, ko sarkewa, ko cututtukan cututtukan epithelial wadanda ke fama da cutar huhu, pleura ko mediastinum waɗanda ba su da shaidar asibiti game da cutar mai aiki (NED), ko ƙananan cututtukan saura (MRD) waɗanda ba za a iya samun damar su ta hanyar biopsy mara haɗari ko raguwa / radiation bayan ingantaccen magani da aka kammala a cikin makonni 26 da suka gabata . - Marasa lafiya dole ne su kasance shekaru 18 ko sama da shekaru tare da yanayin aikin ECOG na 0 2. - Dole ne marassa lafiya su sami isasshen kasusuwan kasusuwa, koda, hanta, huhu da aikin zuciya. - Marasa lafiya bazai kasance kan magungunan ƙwayoyin cuta ba lokacin rigakafin farawa. Zane: - Bayan dawowa daga tiyata, chemotherapy, ko chemo / XRT, marasa lafiya tare da NED ko MRD za a yi musu rigakafi ta hanyar allurar IM tare da ƙwayoyin salula na H1299 da Iscomatrix (TM) adjuvant kowane wata na watanni 6. - Za a yi amfani da allurar rigakafin tare ko ba tare da amfani da maganin ba da magani na cyclophosphamide da selecoxib. - Za a yi rikodin cututtukan ƙwayoyin cuta da amsawar rigakafi ga farfadowa. Maganin rigakafin rigakafin rigakafin rigakafin rigakafin rigakafin rigakafi da kuma adreshin kwayar halitta zuwa ga daidaitaccen kwamiti na antigens na CT da kuma ƙwayoyin ɓarkewar autologous (idan akwai) kuma za a tantance lymphocytes na EBV kafin da bayan alurar riga kafi. - Za a tantance lambobi / kashi-kashi da kuma aiki na ƙwayoyin halitta na T a cikin jini gefe kafin, rigakafin, da kuma bayan rigakafin. - Za a bi marasa lafiya a asibitin tare da daukar hoto na yau da kullun har sai cutar ta sake faruwa.

Wuri: Cibiyoyin Kula da Kiwon Lafiya na Nationalasa, Bethesda, Maryland