Research/key-initiatives/ras/outreach/publications

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Publications from the RAS Initiative

The NCI RAS Initiative has a "hub-and-spokes" structure, in that its scientists work both independently and in collaboration with academic and commercial entities. The list of RAS Initiative publications below reflects the balance between the public responsibilities of the National Cancer Institute and the requirements of our external partners.

Authors who names are marked with an asterisk (*) are part of the RAS Initiative.

  • Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder

Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD Jr, Alexander P*, Van QN*, Moree B, Stephen AG*, Weber DJ, Salafsky J, McCormick F* Proc Natl Acad Sci U S A 2019 PubMed PMID: 31399543

  • PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b

McLean MA, Stephen AG*, Sligar SG Biochemistry 2019 PubMed PMID: 31339036

  • Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes

Barklis E, Stephen AG*, Staubus AO, Barklis RL, Alfadhli A J Mol Biol 2019 PubMed PMID: 31330153

  • Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

Dharmaiah S*, Tran TH*, Messing S*, Agamasu C*, Gillette WK*, Yan W*, Waybright T*, Alexander P*, Esposito D*, Nissley DV*, McCormick F*, Stephen AG*, Simanshu DK* Sci Rep 2019 PubMed PMID: 31324887

  • Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer

Wang MT, Fer N*, Galeas J, Collisson EA, Kim SE, Sharib J, McCormick F* Nat Commun 2019 PubMed PMID: 31296870

  • Membrane curvature sensing of the lipid-anchored K-Ras small GTPase

Liang H, Mu H, Jean-Francois F*, Lakshman B*, Sarkar-Banerjee S, Zhuang Y, Zeng Y, Gao W, Zaske AM, Nissley DV*, Gorfe AA, Zhao W, Zhou Y Life Sci Alliance 2019 PubMed PMID: 31296567

  • Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

Desir S, Wong P, Turbyville T*, Chen D*, Shetty M, Clark C, Zhai E, Romin Y, Manova-Todorova K, Starr TK, Nissley DV, Steer CJ, Subramanian S, Lou E Cancers (Basel) 2019 PubMed PMID: 31247990

  • Production of Farnesylated and Methylated Proteins in an Engineered Insect Cell System

Gillette W*, Frank P*, Perkins S*, Drew M*, Grose C*, Esposito D* Methods Mol Biol 2019 PubMed PMID: 31152410

  • Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors

Bai RY, Esposito D*, Tam AJ, McCormick F*, Riggins GJ, Wade Clapp D, Staedtke V Gene Ther 2019 PubMed PMID: 31127187

  • New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics

Esposito D*, Stephen AG*, Turbyville TJ*, Holderfield M* Semin Cancer Biol 2019 PubMed PMID: 29432816

  • KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner

Agamasu C*, Ghirlando R, Taylor T*, Messing S*, Tran TH*, Bindu L*, Tonelli M, Nissley DV*, McCormick F*, Stephen AG* Biophys Journal 2019 PubMed PMID: 30846362

  • Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane

Lakshman B*, Messing S*, Schmid EM, Clogston JD, Gillette WK*, Esposito D*, Kessing B*, Fletcher DA, Nissley DV*, McCormick F*, Stephen AG*, Jean-Francois FL* J Biol Chem 2018 PubMed ID: 30559287

  • GradientScanSurv-An exhaustive association test method for gene expression data with censored survival outcome

Yi M*, Zhu R, Stephens RM* PloS One 2018 PubMed ID: 30517129

  • Label-Free Time-Gated Luminescent Detection Method for the Nucleotides with Varying Phosphate Content

Kopra K, Seppälä T, Rabara D*, Abreu-Blanco M*, Kulmala S, HolderfieldM*, Härmä H Sensors (Basel) 2018 PubMed ID: 30453509

  • The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L*, Abreu-Blanco M*, Anderson WF, Gaponenko V, Stephen AG*, Holderfield M*, Satchell KJF Sci Signal 2018 PubMed ID: 30279169

  • Production of authentic geranylgeranylated KRAS4b using an engineered baculovirus system

Procter L*, Grose C*, Esposito D* Protein Expr Purif 2018 PubMed ID: 29936133

  • Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics

Ye X*, Luke BT, Wei BR, Kaczmarczyk JA, Loncarek J, Dwyer JE, Johann DJ, Saul RG, Nissley DV*, McCormick F*, Whiteley GR*, Blonder J* Oncotarget 2018 PubMed ID: 29899869

  • Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

Travers T, López CA, Van QN*, Neale C, Tonelli M, Stephen AG*, Gnanakaran S Sci Rep 2018 PubMed ID: 29855542

  • Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G*, Boja ES, Rodriguez H, Kelleher NL Proc Natl Acad Sci USA 2018 PubMed ID: 29610327

  • Differential Effector Engagement by Oncogenic KRAS

Yuan TL, Amzallag A, Bagni R*, Yi M*, Afghani S, Burgan W*, Fer N*, Strathern LA*, Powell K*, Smith B, Waters AM*, Drubin D, Thomson T, Liao R, Greninger P, Stein GT, Murchie E, Cortez E, Egan RK, Procter L*, Bess M, Cheng KT*, Lee CS, Lee LC, Fellmann C, Stephens R*, Luo J, Lowe SW, Benes CH, McCormick F* Cell Rep 2018 PubMed ID: 29444439

  • New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics

Esposito D*, Stephen AG*, Turbyville TJ*, Holderfield M* Semin Cancer Biol. 2018 PubMed ID: 29432816

  • Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G*, Blonder J*, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA Elife 2018 PubMed ID: 29359686

  • K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions

Chung JK, Lee YK, Denson JP*, Gillette WK*, Alvarez S, Stephen AG*, Groves JT Biophys J. 2018 PubMed ID: 29320680

  • Efforts to Develop KRAS Inhibitors

Holderfield M* Cold Spring Harb Perspect Med 2018 PubMed ID: 29101115

  • Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies

Waters AM*, Ozkan-Dagliyan I, Vaseva AV, Fer N*, Strathern LA*, Hobbs GA, Tessier-Cloutier B, Gillette WK*, Bagni R*, Whiteley GR*, Hartley JL*, McCormick F*, Cox AD, Houghton PJ, Huntsman DG, Philips MR, Der CJ Sci Signal 2018 PubMed ID: 28951536

  • RAS Proteins and Their Regulators in Human Disease

Simanshu DK*, Nissley DV*, McCormick F* Cell 2017 PubMed ID: 28666118

  • Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes

Stephens RM*, Yi M*, Kessing B*, Nissley DV*, McCormick F* Cancer Inform 2017 PubMed ID: 28634423

  • A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation

Yin G, Kistler S, George SD, Kuhlmann N, Garvey L*, Huynh M, Bagni RK*, Lammers M, Der CJ, Campbell SL J Biol Chem 2017 PubMed ID: 28154176

  • RAS signaling: Divide and conquer

Holderfield M*, Morrison DK Nat Chem Biol 2016 PubMed ID: 27984577

  • Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface

Ye X, Chan KC, Waters AM*, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD*, Stephens RM*, Bagni R*, Martinko A, Wells JA, Nissley DV*, McCormick F*, Whiteley G*, Blonder J* Oncotarget 2016 PubMed ID: 27894102

  • Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Ritt DA, Abreu-Blanco MT*, Bindu L*, Durrant DE, Zhou M, Specht SI, Stephen AG*, Holderfield M*, Morrison DK Mol Cell 2016 PubMed ID: 27889448

  • Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

Dharmaiah S*, Bindu L*, Tran TH*, Gillette WK*, Frank PH*, Ghirlando R, Nissley DV*, Esposito D*, McCormick F*, Stephen AG*, Simanshu DK* Proc Natl Acad Sci USA 2016 PubMed ID: 27791178

  • Single Synonymous Mutations in KRAS Cause Transformed Phenotypes in NIH3T3 Cells

Waters AM*, Bagni R*, Portugal F*, Hartley JL* PLoS One 2016 PubMed ID: 27684555

  • Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

Gillette WK*, Esposito D*, Abreu Blanco M*, Alexander P*, Bindu L*, Bittner C*, Chertov O*, Frank PH*, Grose C*, Jones JE*, Meng Z*, Perkins S*, Van Q, Ghirlando R, Fivash M*, Nissley DV*, McCormick F*, Holderfield M*, Stephen AG* Sci Rep 2015 PubMed ID: 26522388

  • Progress in targeting RAF kinases for cancer therapy

Turbyville TJ*, Holderfield M* Per Med 2015 PubMed ID: 29771643

  • Dragging RAS back in the ring

Stephen AG*, Esposito D*, Bagni RK*, McCormick F* Cancer Cell 2014 PubMed ID: 24651010

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