Title: Chair and Senior Member, Molecular Oncology; Program Leader, Cancer Biology and Evolution
Institution: Moffitt Cancer Center
Research: Despite long-standing knowledge that the p53 function is frequently altered in cancer, p53 has persisted as an undruggable target because of its function as a transcription factor and because it lacks an enzymatic activity that can be readily inhibited. To identify novel ways of targeting p53 in cancer, understanding the interrelated biological functions of the p53 family is essential. By further evaluating existing mouse models and several novel high throughput modalities, we may better understand the biological functions of non-coding RNA regulated by the p53 family in cancer metastasis and tumor metabolism.
