Institution: Weill Medical College of Cornell University
Research: Dr. Lyden will explore the possibility that inhibition of specific exosomal cargo or their targets in hematopoietic cells could reverse immunosuppression, pre-metastatic niche formation and the systemic effects of cancer. He will study the mechanisms through which exosome subpopulations and exomeres (the most prominent tumor-secreted particles) regulate immune system mobilization, metabolic changes and plasticity of pre-metastatic and metastatic niches in cancer models and patients.
