Christine A. Iacobuzio-Donahue, M.D., Ph.D.Exit Disclaimer
Title: Attending and Member
Institution: Memorial Sloan Kettering Cancer Center
Research: Pancreatic ductal adenocarcinoma (PDAC) is the most common neoplasm of the pancreas and soon the second most common cancer in the U.S. Iacobuzio-Donahue will research features of intratumoral heterogeneity at the genetic level, what cellular factors influence the evolution of PDA, and if therapies influence PDA evolution. Using whole exome/whole genome sequencing of pancreatic cancer tissues, single cell technologies for copy number alterations and RNA expression, long-term evolution experiments, mouse models and computational models, this research will help with identification of optimal agents and timing of administration based on the evolutionary context of the patients' PDA.
