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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | CML often begins in an early myeloid blood cell when a certain gene change occurs. A section of genes, that includes the ABL gene, on chromosome 9 changes place with a section of genes on chromosome 22, which has the BCR gene. This makes a very short chromosome 22 (called the Philadelphia chromosome) and a very long chromosome 9. An abnormal BCR-ABL gene is formed on chromosome 22. The BCR-ABL gene tells the blood cells to make too much of a protein called tyrosine kinase. Tyrosine kinase causes too many white blood cells (leukemia cells) to be made in the bone marrow. The leukemia cells can build up in the blood and bone marrow so there is less room for healthy white blood cells, red blood cells, and platelets. When this happens, infection, anemia, or easy bleeding may occur. CML is rare in children. |
| h Chinese (zh) | 当某些基因发生变化时，CML通常始于早期髓样血细胞。 9号染色体上包含ABL基因的一部分基因与22号染色体上具有BCR基因的一部分基因发生了变化。 这使22号染色体非常短（称为费城染色体），9号染色体非常长。22号染色体上形成了异常的BCR-ABL基因。BCR-ABL基因告诉血细胞产生过多的蛋白质，称为酪氨酸 激酶。 酪氨酸激酶导致骨髓中产生过多的白细胞（白血病细胞）。 白血病细胞可在血液和骨髓中积聚，因此健康白细胞，红细胞和血小板的空间较小。 发生这种情况时，可能会发生感染，贫血或容易出血。 CML在儿童中很少见。 |
