Difference between revisions of "Research/key-initiatives/ras/ras-central/tools-resources"
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| − | == RAS Tools and Resources == | + | == RAS Tools and Resources == <!--T:1--> |
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[[File:Research-computer.jpg|200px|right]] | [[File:Research-computer.jpg|200px|right]] | ||
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The following are helpful RAS datasets, tools, and resources which we will keep up-to-date. Please email any additional datasets, tools, or resources to SolveRAS@nih.gov and we will add them to the list. The more collaboration we have, the better our chances of solving the challenging RAS problem. | The following are helpful RAS datasets, tools, and resources which we will keep up-to-date. Please email any additional datasets, tools, or resources to SolveRAS@nih.gov and we will add them to the list. The more collaboration we have, the better our chances of solving the challenging RAS problem. | ||
| − | === Databases with RAS Information === | + | === Databases with RAS Information === <!--T:4--> |
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*'''DepMap''' | *'''DepMap''' | ||
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Search for changes in growth, drug sensitivity, and co-dependencies in hundreds of cell lines when genes are knocked out or down. | Search for changes in growth, drug sensitivity, and co-dependencies in hundreds of cell lines when genes are knocked out or down. | ||
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*'''Protein Databank''' | *'''Protein Databank''' | ||
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Protein Databank contains RAS structures. | Protein Databank contains RAS structures. | ||
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*'''GeneCards''' | *'''GeneCards''' | ||
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GeneCards is a searchable, integrated database of human genes that provides comprehensive, updated, and user-friendly information on all known and predicted human genes. | GeneCards is a searchable, integrated database of human genes that provides comprehensive, updated, and user-friendly information on all known and predicted human genes. | ||
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*'''Genomics of Drug Sensitivity in Cancer''' | *'''Genomics of Drug Sensitivity in Cancer''' | ||
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This project is a collaboration between the Cancer Genome Project at the Wellcome Trust Sanger Institute (UK) and the Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center (USA). This work is funded by the Wellcome Trust. | This project is a collaboration between the Cancer Genome Project at the Wellcome Trust Sanger Institute (UK) and the Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center (USA). This work is funded by the Wellcome Trust. | ||
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*'''The Cancer Genome Atlas (TCGA)''' | *'''The Cancer Genome Atlas (TCGA)''' | ||
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The TCGA Data Portal provides a platform for researchers to search, download, and analyze datasets generated by the TCGA program. It contains clinical information, genomic characterization data, and high level sequence analysis of the tumor genomes. | The TCGA Data Portal provides a platform for researchers to search, download, and analyze datasets generated by the TCGA program. It contains clinical information, genomic characterization data, and high level sequence analysis of the tumor genomes. | ||
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*'''Cancer Cell Line Encyclopedia (CCLE)''' | *'''Cancer Cell Line Encyclopedia (CCLE)''' | ||
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The CCLE project at the Broad Institute and is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. | The CCLE project at the Broad Institute and is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. | ||
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*'''cBioPortal''' | *'''cBioPortal''' | ||
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The cBioPortal for Cancer Genomics provides visualization, analysis, and download of large-scale cancer genomics datasets. The portal is developed and maintained by the Computational Biology Center at Memorial Sloan-Kettering Cancer Center. References: Cerami et al. Cancer Discov. 2012 & Gao et al. Sci. Signal. 2013. | The cBioPortal for Cancer Genomics provides visualization, analysis, and download of large-scale cancer genomics datasets. The portal is developed and maintained by the Computational Biology Center at Memorial Sloan-Kettering Cancer Center. References: Cerami et al. Cancer Discov. 2012 & Gao et al. Sci. Signal. 2013. | ||
| + | <!--T:19--> | ||
*'''COSMIC - Catalog of Somatic Mutations in Cancer''' | *'''COSMIC - Catalog of Somatic Mutations in Cancer''' | ||
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COSMIC stores and displays somatic mutation information and related details and contains information relating to human cancers. | COSMIC stores and displays somatic mutation information and related details and contains information relating to human cancers. | ||
| − | === Press Releases and News Articles === | + | === Press Releases and News Articles === <!--T:21--> |
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*Drug Developers Refocus Efforts on RASExit Disclaimer | *Drug Developers Refocus Efforts on RASExit Disclaimer | ||
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*NCI Advisory Boards Give Green Light to RAS Initiative | *NCI Advisory Boards Give Green Light to RAS Initiative | ||
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*U.S. Cancer Institute ‘Megaproject’ to Target Common Cancer-driving ProteinExit Disclaimer | *U.S. Cancer Institute ‘Megaproject’ to Target Common Cancer-driving ProteinExit Disclaimer | ||
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*U.S. National Cancer Institute’s New RAS Project Targets an Old FoeExit Disclaimer | *U.S. National Cancer Institute’s New RAS Project Targets an Old FoeExit Disclaimer | ||
| − | === Additional Resources === | + | === Additional Resources === <!--T:26--> |
| + | <!--T:27--> | ||
*Genetics Home Reference: KRAS Gene Information | *Genetics Home Reference: KRAS Gene Information | ||
| + | <!--T:28--> | ||
*Frederick National Laboratory Advisory Committee (FNLAC) | *Frederick National Laboratory Advisory Committee (FNLAC) | ||
| + | <!--T:29--> | ||
*Introducing the RAS Initiative (video)Exit Disclaimer | *Introducing the RAS Initiative (video)Exit Disclaimer | ||
| + | <!--T:30--> | ||
*The RAS Challenge: A New Mission (video) | *The RAS Challenge: A New Mission (video) | ||
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Latest revision as of 21:48, 29 October 2019
Contents
RAS Tools and Resources
The following are helpful RAS datasets, tools, and resources which we will keep up-to-date. Please email any additional datasets, tools, or resources to SolveRAS@nih.gov and we will add them to the list. The more collaboration we have, the better our chances of solving the challenging RAS problem.
Databases with RAS Information
- DepMap
Search for changes in growth, drug sensitivity, and co-dependencies in hundreds of cell lines when genes are knocked out or down.
- Protein Databank
Protein Databank contains RAS structures.
- GeneCards
GeneCards is a searchable, integrated database of human genes that provides comprehensive, updated, and user-friendly information on all known and predicted human genes.
- Genomics of Drug Sensitivity in Cancer
This project is a collaboration between the Cancer Genome Project at the Wellcome Trust Sanger Institute (UK) and the Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center (USA). This work is funded by the Wellcome Trust.
- The Cancer Genome Atlas (TCGA)
The TCGA Data Portal provides a platform for researchers to search, download, and analyze datasets generated by the TCGA program. It contains clinical information, genomic characterization data, and high level sequence analysis of the tumor genomes.
- Cancer Cell Line Encyclopedia (CCLE)
The CCLE project at the Broad Institute and is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines.
- cBioPortal
The cBioPortal for Cancer Genomics provides visualization, analysis, and download of large-scale cancer genomics datasets. The portal is developed and maintained by the Computational Biology Center at Memorial Sloan-Kettering Cancer Center. References: Cerami et al. Cancer Discov. 2012 & Gao et al. Sci. Signal. 2013.
- COSMIC - Catalog of Somatic Mutations in Cancer
COSMIC stores and displays somatic mutation information and related details and contains information relating to human cancers.
Press Releases and News Articles
- Drug Developers Refocus Efforts on RASExit Disclaimer
- NCI Advisory Boards Give Green Light to RAS Initiative
- U.S. Cancer Institute ‘Megaproject’ to Target Common Cancer-driving ProteinExit Disclaimer
- U.S. National Cancer Institute’s New RAS Project Targets an Old FoeExit Disclaimer
Additional Resources
- Genetics Home Reference: KRAS Gene Information
- Frederick National Laboratory Advisory Committee (FNLAC)
- Introducing the RAS Initiative (video)Exit Disclaimer
- The RAS Challenge: A New Mission (video)
