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== RAS Meetings and Videos == <!--T:1-->

=== Upcoming Seminars, Workshops, and Conferences === <!--T:2-->

<!--T:3-->
'''Pancreatic Cancer: Advances in Science and Clinical Care'''

<!--T:4-->
Friday - Monday, September 6-9, 2019, Boston, USA

<!--T:5-->
'''RAS-Targeted Drug Discovery'''

<!--T:6-->
Tuesday - Thursday, September 17-19, Boston, USA

=== Previous Seminars, Workshops, and Conferences === <!--T:7-->

<!--T:8-->
'''6th International RASopathies Symposium'''

<!--T:9-->
Friday - Sunday, August 2-4, 2019, Baltimore, USA

<!--T:10-->
'''The Regulation and Function of Small GTPases'''

<!--T:11-->
Sunday - Friday, June 23-28, 2019, Olean, New York, USA

<!--T:12-->
The RAS Superfamily and Related Pathways in Health and Disease
Thursday - Friday, May 16-17, 2019, Santander, Cantabria, Spain

<!--T:13-->
'''RAS Initiative Report at AACR Annual Meeting'''

<!--T:14-->
Monday, April 1, 2019, Atlanta, Georgia, USA

<!--T:15-->
'''Targeting RAS Mutant Cancers'''

<!--T:16-->
Sunday - Wednesday, December 9-12, 2018, San Diego, USA

<!--T:17-->
'''5th NCI Pancreatic Cancer Symposium'''

<!--T:18-->
Tuesday - Wednesday, October 2-3, 2018, Bethesda, Maryland, USA

<!--T:19-->
'''Frontiers in RAS Pathobiology and Drug Discovery'''
 
Thursday - Sunday, September 13-16, 2018, Stratton, Vermont, USA

<!--T:20-->
Small G Proteins in Cellular Signaling and Disease
Monday - Thursday, July 9-12, 2018, Cambridge, UK

=== Videos and Recorded Webcasts === <!--T:21-->

<!--T:22-->
'''2018'''

<!--T:23-->
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[[File:Frank-McCormick-photo-from-NPR-story-article.jpg|200px|left]]
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:'''Dr. Frank McCormick, "The RAS Initiative on National Public Radio"'''

<!--T:24-->
:The NCI RAS Initiative was featured on National Public Radio on March 9, 2018. Photo credit: Richard Harris/NPR Used with permission.
|}

<!--T:25-->
'''2017'''

<!--T:26-->
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[[File:Frank-mccormick.jpg|200px|left]]
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:'''Dr. Frank McCormick, "The NCI RAS Initiative at the Frederick National Laboratory for Cancer Research" '''

<!--T:27-->
:At the recent Annual Meeting of the American Association for Cancer Research, Frank McCormick, leader of the NCI RAS Initiative, summarizes recent RI activities.
|}


<!--T:28-->
{|
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[[File:Bert-vogelstein.jpg|200px|left]]
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:'''Dr. Bert Vogelstein, "The Road to Cancer Cures - Discover, Predict, Prevent, and Treat"'''

<!--T:29-->
:Bert Vogelstein reflects on why we can cure cancer in mice but not so well in people, and on the sources of mutations in cancer.
|}


<!--T:30-->
{|
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[[File:Charles-sawyers.jpg|200px|left]]
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:'''Dr. Charles Sawyers, "New Twists on Cancer Drug Resistance"'''

<!--T:31-->
:As drugs that attack RAS directly become available, cancers will inevitably develop resistance. What Charles Sawyers tells us about resistance mechanisms in prostate cancer gives us hope that resistance to RAS therapies can be overcome.
|}


<!--T:32-->
'''2015'''

<!--T:33-->
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[[File:Mccormick-targeting-k-ras-induced-stem-ness.jpg|200px|left]]
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:'''Dr. Frank McCormick, "Targeting K-Ras Induced Stem-ness"'''

<!--T:34-->
:Dr. Frank McCormick, UCSF, describes recent progress in understanding of connections between KRAS and stem-ness. June 11, 2015, at the National Cancer Institute, Frederick, Maryland.
|}


<!--T:35-->
{|
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[[File:AACR-2015-videos-thumb.jpg|200px|left]]
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:'''Free videos from the 2015 AACR Annual Meeting'''

<!--T:36-->
:All the scientific presentations from the 2015 Annual Meeting of the American Association for Cancer Research in Philadelphia, USA that are available for viewing without charge may now be found on the AACR web site.
|}


<!--T:37-->
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[[File:Drug-screening-targeting-KRAS-thumbnail.jpg|200px|left]]
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:'''Drug Screens Targeting KRASExit Disclaimer'''

<!--T:38-->
:Dr. Matt Holderfield of the Frederick National Lab describes the development of multiple drug screening platforms targeting KRAS in the NCI RAS Initiative. April 21, 2015 at the AACR Annual Meeting, Philadelphia, USA.
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<!--T:39-->
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[[File:Michael-stratton-thumbnail.jpg|200px|left]]
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:'''How Do the Mutations Underlying Cancers Arise?'''

<!--T:40-->
:Dr. Michael Stratton of the Welcome Trust Sanger Institute, Cambridge, UK describes new insights into the mutational processes that drive cancers. (Dr. Stratton's sciencific remarks begin five minutes into the video.) April 19, 2015 at the AACR Annual Meeting, Philadelphia USA.
|}


<!--T:41-->
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[[File:Ras-demystifying-medicine-2015-bates-mccormick-thumb.jpg|200px|left]]
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:'''Demystifying Medicine 2015 - RAS: A Cancer Mechanism and Target'''

<!--T:42-->
:Dr. Susan Bates of the NCI's Developmental Therapeutics Branch and Dr. Frank McCormick, science advisor to the NCI RAS Initiative, describe the impact of RAS mutations on human health, and new information on regulation of RAS signaling. February 10, 2015 at the National Cancer Institute, Bethesda, Maryland
|}


<!--T:43-->
'''2014'''

<!--T:44-->
{|
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[[File:Barbacid-thumb.jpg|200px|left]]
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:'''Dr. Mariano Barbacid, "Targeting K-RAS Driven Cancer"'''

<!--T:45-->
:Dr. Mariano Barbacid of the Centro Nacional de Investigaciones Oncologicas in Madrid, Spain describes how engineered mouse models are being used to understand the role of KRAS in human cancers. November 12, 2014, at the Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland
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<!--T:46-->
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[[File:Benes-thumb.jpg|200px|left]]
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:'''Dr. Cyril Benes, "Identification of Drug Response Predictors and Therapeutic Strategies by High-Throughput Cell Line Screening"'''

<!--T:47-->
:Dr. Cyril Benes of Massachusetts General Hospital and Harvard Medical School describes his lab's efforts to correlate genotypes and other molecular data with drug sensitivities in hundreds of cell lines derived from human tumors. October 17, 2014, at the Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland
|}

=== 2014 RAS Symposium Presentations === <!--T:48-->

<!--T:49-->
The following ten presentations were presented at the symposium "Targeting RAS Now for Future Cancer Therapy," held at the University of California, San Francisco (UCSF), June 19 and 20, 2014


<!--T:50-->
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[[File:Mccormick-intro.jpg|200px|left]]
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: '''Symposium 2014: Targeting RAS Now for Future Cancer Therapy – Introduction'''

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:Dr. Frank McCormick, Director of the UCSF Cancer Center and advisor to the RAS Initiative at FNLCR, describes what we do not know about RAS-driven cancers.
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<!--T:52-->
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[[File:Shokat-targeting.jpg|200px|left]]
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: '''Symposium 2014: Targeting Mutant KRAS with Small Molecules'''

<!--T:53-->
:Dr. Kevan Shokat, UCSF, describes how his group developed a small molecule that directly targets a KRAS mutant found in many human cancers.
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<!--T:54-->
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[[File:Fesick-targeting.jpg|200px|left]]
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: '''Symposium 2014: Targeting KRAS Directly and Indirectly'''

<!--T:55-->
:Dr. Stephen W. Fesik, Vanderbilt-Ingram Cancer Center, describes how fragment-based methods can be applied to trying to drug the undruggable.
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<!--T:56-->
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[[File:Fagin-merlin.jpg|200px|left]]
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:'''Symposium 2014: Merlin/NF2 Inhibits RAS Tumorigenesis Through YAP'''

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:Dr. James A. Fagin, Memorial Sloan Kettering, describes mechanisms underlying signaling downstream of RAS proteins.
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<!--T:58-->
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[[File:Morrison-inhibitors.jpg|200px|left]]
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:'''Symposium 2014: Inhibitors of Interactions between BRAF and CRAF in KRAS Cancers'''

<!--T:59-->
:Dr. Deborah Morrison, NCI, describes inhibitors of RAF-RAF dimerization.
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<!--T:60-->
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[[File:Downward-vulnerabilities.jpg|200px|left]]
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: '''Symposium 2014: Finding vulnerabilities in cells dependent on mutant KRAS'''

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:Dr. Julian Downward, the Cancer Research UK London Institute, describes interactions between PI3K and KRAS, synthetic lethal screens, and circulating tumor DNA.
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<!--T:62-->
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[[File:Shannon-limits.jpg|200px|left]]
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: '''Symposium 2014: Limits to Tolerance of Increased RAS Signaling in Cancer'''

<!--T:63-->
:Dr. Kevin Shannon, UCSF, describes how dominant oncogenes, Notch and KRAS, are down-regulated in drug-resistant leukemias.
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<!--T:64-->
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[[File:Jackson-tumor.jpg|200px|left]]
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:'''Symposium 2014: Tumor heterogeneity in cancer drug response, resistance, and relapse'''

<!--T:65-->
:Dr. Erica Jackson, Genentech, describes enrichment of cells with stem cell markers in populations of lung cancer cells.
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[[File:Collisson-role.jpg|200px|left]]
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: '''Symposium 2014: The Role of NF1 Loss in Lung and Pancreatic Cancer'''

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:Dr. Eric Collisson, UCSF, describes genomics and patient studies that highlight the role of NF1 loss in human cancers.
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<!--T:68-->
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[[File:Mccormick-target.jpg|200px|left]]
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:'''Symposium 2014: New targets and tools to attack KRAS cancers'''

<!--T:69-->
:Dr. Frank McCormick, science advisor to the RAS Initiative at FNLCR, describes work in his lab at UCSF to develop new tools and identify new targets relevant to KRAS cancers.
|}


<!--T:70-->
{|
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[[File:New-targets-thumb.jpg|200px|left]]
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: '''Dr. Frank McCormick, "New Targets on the RAS Pathway"'''

<!--T:71-->
:Dr. Frank McCormick describes recent experiments to understand KRAS signaling in cancer at the AACR Annual Meeting, April 5, 2014, San Diego, California USA
|}

=== Structural Aspects of RAS GTPases === <!--T:72-->


<!--T:73-->
{|
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[[File:Wittinghofer-part-1-thumb.jpg|200px|left]]




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:'''Dr. Alfred Wittinghofer, "GTP-binding Proteins as Molecular Switches", Part 1'''

<!--T:75-->
:Dr. Alfred Wittinghofer explains how solving the three-dimensional structure of RAS and other G-proteins allowed him to understand the conserved mechanism by which G-proteins can act as switches. June 19, 2011
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<!--T:76-->
{|
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[[File:Wittinghofer-part-2-thumb.jpg|200px|left]]




<!--T:77-->
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:'''Dr. Alfred Wittinghofer, "GTP-binding Proteins as Molecular Switches", Part 2'''

<!--T:78-->
:In the second part of Dr. Wittinghofer's talk he explains the link between GTPases and disease. June 19, 2011
|}
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